1341. Effect of Acetazolamide vs Placebo on Duration of Invasive Mechanical Ventilation Among Patients With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial.
作者: Christophe Faisy.;Ferhat Meziani.;Benjamin Planquette.;Marc Clavel.;Arnaud Gacouin.;Caroline Bornstain.;Francis Schneider.;Alexandre Duguet.;Sébastien Gibot.;Nicolas Lerolle.;Jean-Damien Ricard.;Olivier Sanchez.;Michel Djibre.;Jean-Louis Ricome.;Antoine Rabbat.;Nicholas Heming.;Saïk Urien.;Maxime Esvan.;Sandrine Katsahian.; .
来源: JAMA. 2016年315卷5期480-8页
Acetazolamide has been used for decades as a respiratory stimulant for patients with chronic obstructive pulmonary disease (COPD) and metabolic alkalosis, but no large randomized placebo-controlled trial is available to confirm this approach.
1342. Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial.
作者: Claus Bachert.;Leda Mannent.;Robert M Naclerio.;Joaquim Mullol.;Berrylin J Ferguson.;Philippe Gevaert.;Peter Hellings.;Lixia Jiao.;Lin Wang.;Robert R Evans.;Gianluca Pirozzi.;Neil M Graham.;Brian Swanson.;Jennifer D Hamilton.;Allen Radin.;Namita A Gandhi.;Neil Stahl.;George D Yancopoulos.;E Rand Sutherland.
来源: JAMA. 2016年315卷5期469-79页
Dupilumab has demonstrated efficacy in patients with asthma and atopic dermatitis, which are both type 2 helper T-cell-mediated diseases.
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