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1221. Exome sequencing identifies mutant TINF2 in a family with pulmonary fibrosis.
作者: Jonathan K Alder.;Susan E Stanley.;Christa L Wagner.;Makenzie Hamilton.;Vidya Sagar Hanumanthu.;Mary Armanios.
来源: Chest. 2015年147卷5期1361-1368页
Short telomeres are a common defect in idiopathic pulmonary fibrosis, yet mutations in the telomerase genes account for only a subset of these cases.
1222. Natural history of typical pulmonary carcinoid tumors: a comparison of nonsurgical and surgical treatment.
The natural history of typical pulmonary carcinoid tumors has not been described and has important implications for counseling elderly patients or patients with high operative-risk about surgical resection.
1223. How Common Is Airflow Limitation in Patients With Emphysema on CT Scan of the Chest?
作者: Sanjiva M Lutchmedial.;Whitney G Creed.;Alastair J Moore.;Ryan R Walsh.;George E Gentchos.;David A Kaminsky.
来源: Chest. 2015年148卷1期176-184页
COPD has traditionally been defined by the presence of irreversible airflow limitation on spirometry using either the GOLD (Global Initiative for Chronic Obstructive Lung Disease) or American Thoracic Society/European Respiratory Society criteria (lower limit of normal [LLN]). We have observed that some patients with clinical COPD and emphysema on chest CT scan have no obstruction on spirometry. The purpose of this study was to assess the prevalence of obstruction by GOLD and LLN criteria in patients with emphysema on CT scan and determine which radiographic criteria were associated with a clinical diagnosis of COPD.
1226. Tools for assessing outcomes in studies of chronic cough: CHEST guideline and expert panel report.
作者: Louis-Philippe Boulet.;Remy R Coeytaux.;Douglas C McCrory.;Cynthia T French.;Anne B Chang.;Surinder S Birring.;Jaclyn Smith.;Rebecca L Diekemper.;Bruce Rubin.;Richard S Irwin.; .
来源: Chest. 2015年147卷3期804-814页
Since the publication of the 2006 American College of Chest Physicians (CHEST) cough guidelines, a variety of tools has been developed or further refined for assessing cough. The purpose of the present committee was to evaluate instruments used by investigators performing clinical research on chronic cough. The specific aims were to (1) assess the performance of tools designed to measure cough frequency, severity, and impact in adults, adolescents, and children with chronic cough and (2) make recommendations or suggestions related to these findings.
1228. Chemoreceptor Responsiveness at Sea Level Does Not Predict the Pulmonary Pressure Response to High Altitude.
作者: Ryan L Hoiland.;Glen E Foster.;Joseph Donnelly.;Mike Stembridge.;Chris K Willie.;Kurt J Smith.;Nia C Lewis.;Samuel J E Lucas.;Jim D Cotter.;David J Yeoman.;Kate N Thomas.;Trevor A Day.;Mike M Tymko.;Keith R Burgess.;Philip N Ainslie.
来源: Chest. 2015年148卷1期219-225页
The hypoxic ventilatory response (HVR) at sea level (SL) is moderately predictive of the change in pulmonary artery systolic pressure (PASP) to acute normobaric hypoxia. However, because of progressive changes in the chemoreflex control of breathing and acid-base balance at high altitude (HA), HVR at SL may not predict PASP at HA. We hypothesized that resting oxygen saturation as measured by pulse oximetry (Spo₂) at HA would correlate better than HVR at SL with PASP at HA.
1229. Children with chronic cough: when is watchful waiting appropriate? development of likelihood ratios for assessing children with chronic cough.
作者: Anne B Chang.;Peter P Van Asperen.;Nicholas Glasgow.;Colin F Robertson.;Craig M Mellis.;I Brent Masters.;Louis I Landau.;Laurel Teoh.;Irene Tjhung.;Helen L Petsky.;Peter S Morris.
来源: Chest. 2015年147卷3期745-753页
Chronic cough is associated with poor quality of life and may signify a serious underlying disease. Differentiating nonspecific cough (when watchful waiting can be safely undertaken) from specific cough (treatment and further investigations are beneficial) would be clinically useful. In 326 children, we aimed to (1) determine how well cough pointers (used in guidelines) differentiate specific from nonspecific cough and (2) describe the clinical profile of children whose cough resolved without medications (spontaneous resolution).
1230. Time Trends of Aspirin and Warfarin Use on Stroke and Bleeding Events in Chinese Patients With New-Onset Atrial Fibrillation.
Much of the clinical epidemiology and treatment patterns for patients with atrial fibrillation (AF) are derived from Western populations. Limited data are available on antithrombotic therapy use over time and its impact on the stroke or bleeding events in newly diagnosed Chinese patients with AF. The present study investigates time trends in warfarin and aspirin use in China in relation to stroke and bleeding events in a Chinese population.
1231. Diffusing capacity for carbon monoxide correlates best with tissue volume from quantitative CT scanning analysis.
作者: Igor Barjaktarevic.;Steven Springmeyer.;Xavier Gonzalez.;William Sirokman.;Harvey O Coxson.;Christopher B Cooper.
来源: Chest. 2015年147卷6期1485-1493页
Quantitative analysis of high-resolution chest CT scan (QCT) is an established method for determining the severity and distribution of lung parenchymal destruction inpatients with emphysema. Diffusing capacity of the lung for carbon monoxide (D(LCO)) is a traditional physiologic measure of emphysema severity and is probably influenced more by destruction of the alveolar capillary bed than by membrane diffusion per se. We reasoned that D(LCO) should correlate with tissue volume from QCT.
1232. Endotracheal tubes for critically ill patients: an in vivo analysis of associated tracheal injury, mucociliary clearance, and sealing efficacy.
作者: Gianluigi Li Bassi.;Nestor Luque.;Joan Daniel Martí.;Eli Aguilera Xiol.;Marta Di Pasquale.;Valeria Giunta.;Talitha Comaru.;Montserrat Rigol.;Silvia Terraneo.;Francesca De Rosa.;Mariano Rinaudo.;Ernesto Crisafulli.;Rogelio Cesar Peralta Lepe.;Carles Agusti.;Carmen Lucena.;Miguel Ferrer.;Laia Fernández.;Antoni Torres.
来源: Chest. 2015年147卷5期1327-1335页
Improvements in the design of the endotracheal tube (ETT) have been achieved in recent years. We evaluated tracheal injury associated with ETTs with novel high-volume low-pressure (HVLP) cuffs and subglottic secretions aspiration (SSA) and the effects on mucociliary clearance (MCC).
1233. Predictors of clinical use of pleurodesis and/or indwelling pleural catheter therapy for malignant pleural effusion.
作者: Edward T H Fysh.;Silvia Bielsa.;Charley A Budgeon.;Catherine A Read.;Jose M Porcel.;Nick A Maskell.;Y C Gary Lee.
来源: Chest. 2015年147卷6期1629-1634页
The clinical course of patients with malignant pleural effusions (MPEs) varies. The decision to undertake "definitive therapy" (pleurodesis, indwelling pleural catheter [IPC], or both) for MPEs is decided on a case-by-case basis. Identifying factors that predict definitive therapy may help guide early initiation of treatment. The aim of the study was to identify clinical, laboratory, and radiologic predictors associated with clinicians' prescription of definitive therapy for patients with MPE.
1234. A pilot study of the noninvasive assessment of the lung microbiota as a potential tool for the early diagnosis of ventilator-associated pneumonia.
作者: Addison K May.;Jacob S Brady.;Joann Romano-Keeler.;Wonder P Drake.;Patrick R Norris.;Judith M Jenkins.;Richard J Isaacs.;Erik M Boczko.
来源: Chest. 2015年147卷6期1494-1502页
Ventilator-associated pneumonia (VAP) remains a common complication in critically ill surgical patients, and its diagnosis remains problematic. Exhaled breath contains aerosolized droplets that reflect the lung microbiota. We hypothesized that exhaled breath condensate fluid (EBCF) in hygroscopic condenser humidifier/heat and moisture exchanger (HCH/HME) filters would contain bacterial DNA that qualitatively and quantitatively correlate with pathogens isolated from quantitative BAL samples obtained for clinical suspicion of pneumonia.
1235. Comparison of hospital mortality and long-term survival in patients with acute lung injury/ARDS vs cardiogenic pulmonary edema.
作者: Christopher N Schmickl.;Michelle Biehl.;Gregory A Wilson.;Ognjen Gajic.
来源: Chest. 2015年147卷3期618-625页
Early differential diagnosis of acute lung injury (ALI) vs cardiogenic pulmonary edema (CPE) is important for selecting the most appropriate therapy, but the prognostic implications of this distinction have not been studied. Accurate prognostic information is essential for providing appropriate informed consent prior to initiation of mechanical ventilation.
1236. Supplementing defect in club cell secretory protein attenuates airway inflammation in COPD.
作者: Anne Sophie Gamez.;Delphine Gras.;Aurélie Petit.;Lucie Knabe.;Nicolas Molinari.;Isabelle Vachier.;Pascal Chanez.;Arnaud Bourdin.
来源: Chest. 2015年147卷6期1467-1476页
Club cell secretory protein (CCSP) is a protective biomarker associated with annual decline in lung function. COPD progression results from an imbalance between injury and repair initially triggered by cigarette smoking.
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