当前位置: 首页 >> 检索结果
101. Gut microbiota, metabolome and immune signatures in patients with uncomplicated diverticular disease.
作者: Giovanni Barbara.;Eleonora Scaioli.;Maria Raffaella Barbaro.;Elena Biagi.;Luca Laghi.;Cesare Cremon.;Giovanni Marasco.;Antonio Colecchia.;Gianfranco Picone.;Nunzio Salfi.;Francesco Capozzi.;Patrizia Brigidi.;Davide Festi.
来源: Gut. 2017年66卷7期1252-1261页
The engagement of the gut microbiota in the development of symptoms and complications of diverticular disease has been frequently hypothesised. Our aim was to explore colonic immunocytes, gut microbiota and the metabolome in patients with diverticular disease in a descriptive, cross-sectional, pilot study.
102. Real-life chromoendoscopy for neoplasia detection and characterisation in long-standing IBD.
作者: Sabela Carballal.;Sandra Maisterra.;Antonio López-Serrano.;Antonio Z Gimeno-García.;María Isabel Vera.;José Carlos Marín-Garbriel.;José Díaz-Tasende.;Lucía Márquez.;Marco Antonio Álvarez.;Luis Hernández.;Luisa De Castro.;Jordi Gordillo.;Ignasi Puig.;Pablo Vega.;Marco Bustamante-Balén.;Juan Acevedo.;Beatriz Peñas.;María López-Cerón.;Elena Ricart.;Miriam Cuatrecasas.;Mireya Jimeno.;María Pellisé.; .
来源: Gut. 2018年67卷1期70-78页
Outside clinical trials, the effectiveness of chromoendoscopy (CE) for long-standing IBD surveillance is controversial. We aimed to assess the effectiveness of CE for neoplasia detection and characterisation, in real-life.
103. Subclonal diversity arises early even in small colorectal tumours and contributes to differential growth fates.
作者: Chelsie K Sievers.;Luli S Zou.;Perry J Pickhardt.;Kristina A Matkowskyj.;Dawn M Albrecht.;Linda Clipson.;Jeffery W Bacher.;B Dustin Pooler.;Fouad J Moawad.;Brooks D Cash.;Mark Reichelderfer.;Tien N Vo.;Michael A Newton.;Bret R Larget.;Richard B Halberg.
来源: Gut. 2017年66卷12期2132-2140页
The goal of the study was to determine whether the mutational profile of early colorectal polyps correlated with growth behaviour. The growth of small polyps (6-9 mm) that were first identified during routine screening of patients was monitored over time by interval imaging with CT colonography. Mutations in these lesions with known growth rates were identified by targeted next-generation sequencing. The timing of mutational events was estimated using computer modelling and statistical inference considering several parameters including allele frequency and fitness.
105. Extracellular lipid-free apolipoprotein E inhibits HCV replication and induces ABCG1-dependent cholesterol efflux.
作者: Emilie Crouchet.;Mathieu Lefèvre.;Eloi R Verrier.;Marine A Oudot.;Thomas F Baumert.;Catherine Schuster.
来源: Gut. 2017年66卷5期896-907页
The HCV life cycle and the lipid metabolism are inextricably intertwined. In the blood, HCV virions are associated with lipoproteins, forming lipoviroparticles (LVPs), which are the most infectious form of the virus. Apolipoprotein E (apoE), a key LVP component, plays an essential role in HCV entry, assembly and egress. ApoE is also a cell host factor involved in lipoprotein homeostasis. Although the majority of apoE is associated with lipoproteins, a lipid-free (LF) form exists in blood. However, the role of LF-apoE in both lipid metabolism and HCV life cycle is poorly understood.
107. Daclatasvir plus sofosbuvir, with or without ribavirin, achieved high sustained virological response rates in patients with HCV infection and advanced liver disease in a real-world cohort.
作者: Tania M Welzel.;Jörg Petersen.;Kerstin Herzer.;Peter Ferenci.;Michael Gschwantler.;Heiner Wedemeyer.;Thomas Berg.;Ulrich Spengler.;Ola Weiland.;Marc van der Valk.;Jürgen Rockstroh.;Markus Peck-Radosavljevic.;Yue Zhao.;Maria Jesus Jimenez-Exposito.;Stefan Zeuzem.
来源: Gut. 2016年65卷11期1861-1870页
We assessed the effectiveness and safety of daclatasvir (DCV) plus sofosbuvir (SOF), with or without ribavirin (RBV), in a large real-world cohort, including patients with advanced liver disease.
108. The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000-2015).
作者: Imran Aziz.;Mohammad F Peerally.;Jodie-Hannah Barnes.;Vigneswaran Kandasamy.;Jack C Whiteley.;David Partridge.;Patricia Vergani.;Simon S Cross.;Peter H Green.;David S Sanders.
来源: Gut. 2017年66卷9期1563-1572页
Seronegative villous atrophy (SNVA) is commonly attributed to coeliac disease (CD). However, there are other causes of SNVA. More recently angiotensin-2-receptor-blockers (A2RBs) have been reported as an association but data on SNVA have been limited to centres evaluating complex case referrals and not SNVA in general.
109. Non-alcoholic fatty liver disease and progression of coronary artery calcium score: a retrospective cohort study.
作者: Dong Hyun Sinn.;Danbee Kang.;Yoosoo Chang.;Seungho Ryu.;Seonhye Gu.;Hyunkyoung Kim.;Donghyeong Seong.;Soo Jin Cho.;Byoung-Kee Yi.;Hyung-Doo Park.;Seung Woon Paik.;Young Bin Song.;Mariana Lazo.;Joao A C Lima.;Eliseo Guallar.;Juhee Cho.;Geum-Youn Gwak.
来源: Gut. 2017年66卷2期323-329页
Non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, was associated with subclinical atherosclerosis in many cross-sectional studies, but the prospective association between NAFLD and the progression of atherosclerosis has not been evaluated. This study was conducted to evaluate the association between NAFLD and the progression of coronary atherosclerosis.
110. Stress activates pronociceptive endogenous opioid signalling in DRG neurons during chronic colitis.
作者: Raquel Guerrero-Alba.;Eduardo E Valdez-Morales.;Nestor N Jimenez-Vargas.;Cintya Lopez-Lopez.;Josue Jaramillo-Polanco.;Takanobu Okamoto.;Yasmin Nasser.;Nigel W Bunnett.;Alan E Lomax.;Stephen J Vanner.
来源: Gut. 2017年66卷12期2121-2131页
Psychological stress accompanies chronic inflammatory diseases such as IBD, and stress hormones can exacerbate pain signalling. In contrast, the endogenous opioid system has an important analgesic action during chronic inflammation. This study examined the interaction of these pathways.
111. Helicobacter pylori-induced cell death is counteracted by NF-κB-mediated transcription of DARPP-32.
作者: Shoumin Zhu.;Mohammed Soutto.;Zheng Chen.;DunFa Peng.;Judith Romero-Gallo.;Uma S Krishna.;Abbes Belkhiri.;M Kay Washington.;Richard Peek.;Wael El-Rifai.
来源: Gut. 2017年66卷5期761-762页
DARPP-32 is a frequently amplified and overexpressed gene that promotes several oncogenic functions in gastric cancer. Herein, we investigated the relationship between Helicobacter pylori infection, proinflammatory NF-κB activation and regulation of DARPP-32.
113. Discrepancies between patient-reported outcomes, and endoscopic and histological appearance in UC.
作者: Jean-Frédéric Colombel.;Mary E Keir.;Alexis Scherl.;Rui Zhao.;Gert de Hertogh.;William A Faubion.;Timothy T Lu.
来源: Gut. 2017年66卷12期2063-2068页
Both endoscopy and histology may be included in the definition of mucosal healing in UC. This study aimed to establish the association between patient-reported outcomes, specifically symptom measures, and the presence of inflammation as measured by endoscopy and histology in UC.
115. Lack of evidence for germline RNF43 mutations in patients with serrated polyposis syndrome from a large multinational study.
作者: Daniel D Buchanan.;Mark Clendenning.;Li Zhuoer.;Jenna R Stewart.;Sharelle Joseland.;Sonja Woodall.;Julie Arnold.;Kara Semotiuk.;Melyssa Aronson.;Spring Holter.;Steven Gallinger.;Mark A Jenkins.;Kevin Sweet.;Finlay A Macrae.;Ingrid M Winship.;Susan Parry.;Christophe Rosty.; .
来源: Gut. 2017年66卷6期1170-1172页 117. Lysophosphatidylcholine acyltransferase 1 is downregulated by hepatitis C virus: impact on production of lipo-viro-particles.
作者: Frauke Beilstein.;Matthieu Lemasson.;Véronique Pène.;Dominique Rainteau.;Sylvie Demignot.;Arielle R Rosenberg.
来源: Gut. 2017年66卷12期2160-2169页
HCV is intimately linked with the liver lipid metabolism, devoted to the efflux of triacylglycerols stored in lipid droplets (LDs) in the form of triacylglycerol-rich very-low-density lipoproteins (VLDLs): (i) the most infectious HCV particles are those of lowest density due to association with triacylglycerol-rich lipoproteins and (ii) HCV-infected patients frequently develop hepatic steatosis (increased triacylglycerol storage). The recent identification of lysophosphatidylcholine acyltransferase 1 (LPCAT1) as an LD phospholipid-remodelling enzyme prompted us to investigate its role in liver lipid metabolism and HCV infectious cycle.
119. PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury.
作者: Gui-Wei He.;Claudia Günther.;Andreas E Kremer.;Veronika Thonn.;Kerstin Amann.;Christopher Poremba.;Markus F Neurath.;Stefan Wirtz.;Christoph Becker.
来源: Gut. 2017年66卷4期716-723页
Autoimmune hepatitis (AIH) is a severe necroinflammatory liver disease associated with significant mortality. Although loss of hepatocytes is generally recognised as a key trigger of liver inflammation and liver failure, the regulation of hepatic cell death causing AIH remains poorly understood. The aim of this study was to identify molecular mechanisms that drive hepatocyte cell death in the pathogenesis of acute liver injury.
|