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1041. Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit.
作者: David Tooth.;Klara Garsed.;Gulzar Singh.;Luca Marciani.;Ching Lam.;Imogen Fordham.;Annie Fields.;Rawinder Banwait.;Melanie Lingaya.;Robert Layfield.;Maggie Hastings.;Peter Whorwell.;Robin Spiller.
来源: Gut. 2014年63卷5期753-60页
Faecal serine proteases (FSPs) may play a role in irritable bowel syndrome with diarrhoea (IBS-D), but their origin is unclear. We aimed to structurally characterise them and define the impact of colonic cleansing and transit time.
1045. Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells.
作者: Anggakusuma.;Che C Colpitts.;Luis M Schang.;Heni Rachmawati.;Anne Frentzen.;Stephanie Pfaender.;Patrick Behrendt.;Richard J P Brown.;Dorothea Bankwitz.;Joerg Steinmann.;Michael Ott.;Philip Meuleman.;Charles M Rice.;Alexander Ploss.;Thomas Pietschmann.;Eike Steinmann.
来源: Gut. 2014年63卷7期1137-49页
Hepatitis C virus (HCV) infection causes severe liver disease and affects more than 160 million individuals worldwide. People undergoing liver organ transplantation face universal re-infection of the graft. Therefore, affordable antiviral strategies targeting the early stages of infection are urgently needed to prevent the recurrence of HCV infection. The aim of the study was to determine the potency of turmeric curcumin as an HCV entry inhibitor.
1046. AIEC pathobiont instigates chronic colitis in susceptible hosts by altering microbiota composition.
作者: Benoit Chassaing.;Omry Koren.;Frederic A Carvalho.;Ruth E Ley.;Andrew T Gewirtz.
来源: Gut. 2014年63卷7期1069-80页
Inflammatory bowel disease (IBD) is driven by a seemingly aberrant immune response to the gut microbiota with disease development dictated by genetics and environmental factors. A model exemplifying this notion is our recent demonstration that colonisation of adherent-invasive Escherichia coli (AIEC) during microbiota acquisition drove chronic colitis in mice lacking the flagellin receptor TLR5 (T5KO). T5KO colitis persisted beyond AIEC clearance and requires TLR4 and the NLRC4 inflammasome. We hypothesised that AIEC instigates chronic inflammation by increasing microbial lipopolysaccharide (LPS) and flagellin levels.
1047. Fatigue management in patients with IBD: a randomised controlled trial.
作者: Lauran Vogelaar.;Adriaan van't Spijker.;Reinier Timman.;Antonie J P van Tilburg.;DirkJan Bac.;Ton Vogelaar.;Ernst J Kuipers.;Jan J V van Busschbach.;Christien J van der Woude.
来源: Gut. 2014年63卷6期911-8页
To assess the effectiveness of solution-focused therapy (SFT) on fatigue and quality of life (QoL) in patients with fatigued inflammatory bowel disease (IBD).
1048. Individualised therapy is more cost-effective than dose intensification in patients with Crohn's disease who lose response to anti-TNF treatment: a randomised, controlled trial.
作者: Casper Steenholdt.;Jørn Brynskov.;Ole Østergaard Thomsen.;Lars Kristian Munck.;Jan Fallingborg.;Lisbet Ambrosius Christensen.;Gitte Pedersen.;Jens Kjeldsen.;Bent Ascanius Jacobsen.;Anne Sophie Oxholm.;Jakob Kjellberg.;Klaus Bendtzen.;Mark Andrew Ainsworth.
来源: Gut. 2014年63卷6期919-27页
Although the reasons for secondary loss of response to infliximab (IFX) maintenance therapy in Crohn's disease vary, dose intensification is usually recommended. This study investigated the cost-effectiveness of interventions defined by an algorithm designed to identify specific reasons for therapeutic failure.
1050. Functional bowel symptoms in quiescent inflammatory bowel diseases: role of epithelial barrier disruption and low-grade inflammation.
作者: M Vivinus-Nébot.;G Frin-Mathy.;H Bzioueche.;R Dainese.;G Bernard.;R Anty.;J Filippi.;M C Saint-Paul.;M K Tulic.;V Verhasselt.;X Hébuterne.;T Piche.
来源: Gut. 2014年63卷5期744-52页
To determine the role of colonic barrier defects and low-grade inflammation in irritable bowel syndrome (IBS)-like symptoms in quiescent inflammatory bowel disease (IBD).
1054. Proton pump inhibitors and the risk of hospitalisation for community-acquired pneumonia: replicated cohort studies with meta-analysis.
作者: Kristian B Filion.;Dan Chateau.;Laura E Targownik.;Andrea Gershon.;Madeleine Durand.;Hala Tamim.;Gary F Teare.;Pietro Ravani.;Pierre Ernst.;Colin R Dormuth.; .
来源: Gut. 2014年63卷4期552-8页
Previous observational studies suggest that the use of proton pump inhibitors (PPIs) may increase the risk of hospitalisation for community-acquired pneumonia (HCAP). However, the potential presence of confounding and protopathic biases limits the conclusions that can be drawn from these studies. Our objective was, therefore, to examine the risk of HCAP with PPIs prescribed prophylactically in new users of non-steroidal anti-inflammatory drugs (NSAIDs).
1055. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review.
作者: Hashem B El-Serag.;Stephen Sweet.;Christopher C Winchester.;John Dent.
来源: Gut. 2014年63卷6期871-80页
To update the findings of the 2005 systematic review of population-based studies assessing the epidemiology of gastro-oesophageal reflux disease (GERD).
1056. Comparison of detection and miss rates of narrow band imaging, flexible spectral imaging chromoendoscopy and white light at screening colonoscopy: a randomised controlled back-to-back study.
作者: Su Jin Chung.;Donghee Kim.;Ji Hyun Song.;Hae Yeon Kang.;Goh Eun Chung.;Jeongmin Choi.;Young Sun Kim.;Min Jung Park.;Joo Sung Kim.
来源: Gut. 2014年63卷5期785-91页
Virtual chromoendoscopy (CE) is expected to enhance adenoma yield and reduce variation in performance between colonoscopists. This study aimed to compare the efficacy of narrow band imaging (NBI), flexible spectral imaging CE (FICE) and white light (WL) colonoscopy and their impact for less experienced endoscopists.
1058. Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
作者: Suk-Kyun Yang.;Myunghee Hong.;Wanting Zhao.;Yusun Jung.;Jiwon Baek.;Naeimeh Tayebi.;Kyung Mo Kim.;Byong Duk Ye.;Kyung-Jo Kim.;Sang Hyoung Park.;Inchul Lee.;Eun-Ju Lee.;Won Ho Kim.;Jae Hee Cheon.;Young-Ho Kim.;Byung Ik Jang.;Hyun-Soo Kim.;Jai Hyun Choi.;Ja Seol Koo.;Ji Hyun Lee.;Sung-Ae Jung.;Yeoun Joo Lee.;Joo Young Jang.;Hyoung Doo Shin.;Daehee Kang.;Hee-Shang Youn.;Jianjun Liu.;Kyuyoung Song.
来源: Gut. 2014年63卷1期80-7页
Crohn's disease (CD) is an intractable inflammatory bowel disease (IBD) of unknown cause. Recent meta-analysis of the genome-wide association studies (GWAS) and Immunochip data identified 163 susceptibility loci to IBD in Caucasians, however there are limited studies in other populations.
1060. Colonic mucosa-associated diffusely adherent afaC+ Escherichia coli expressing lpfA and pks are increased in inflammatory bowel disease and colon cancer.
作者: Maelle Prorok-Hamon.;Melissa K Friswell.;Abdullah Alswied.;Carol L Roberts.;Fei Song.;Paul K Flanagan.;Paul Knight.;Caroline Codling.;Julian R Marchesi.;Craig Winstanley.;Neil Hall.;Jonathan M Rhodes.;Barry J Campbell.
来源: Gut. 2014年63卷5期761-70页
Colonic mucosa-associated Escherichia coli are increased in Crohn's disease (CD) and colorectal cancer (CRC). They variously haemagglutinate, invade epithelial cell lines, replicate within macrophages, translocate across M (microfold) cells and damage DNA. We investigated genes responsible for these effects and their co-association in colonic mucosal isolates.
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