85. Interim Buprenorphine vs. Waiting List for Opioid Dependence.
作者: Stacey C Sigmon.;Taylor A Ochalek.;Andrew C Meyer.;Bryce Hruska.;Sarah H Heil.;Gary J Badger.;Gail Rose.;John R Brooklyn.;Robert P Schwartz.;Brent A Moore.;Stephen T Higgins.
来源: N Engl J Med. 2016年375卷25期2504-2505页 93. Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis.
作者: Xavier Montalban.;Stephen L Hauser.;Ludwig Kappos.;Douglas L Arnold.;Amit Bar-Or.;Giancarlo Comi.;Jérôme de Seze.;Gavin Giovannoni.;Hans-Peter Hartung.;Bernhard Hemmer.;Fred Lublin.;Kottil W Rammohan.;Krzysztof Selmaj.;Anthony Traboulsee.;Annette Sauter.;Donna Masterman.;Paulo Fontoura.;Shibeshih Belachew.;Hideki Garren.;Nicole Mairon.;Peter Chin.;Jerry S Wolinsky.; .
来源: N Engl J Med. 2017年376卷3期209-220页
An evolving understanding of the immunopathogenesis of multiple sclerosis suggests that depleting B cells could be useful for treatment. We studied ocrelizumab, a humanized monoclonal antibody that selectively depletes CD20-expressing B cells, in the primary progressive form of the disease.
94. Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis.
作者: Stephen L Hauser.;Amit Bar-Or.;Giancarlo Comi.;Gavin Giovannoni.;Hans-Peter Hartung.;Bernhard Hemmer.;Fred Lublin.;Xavier Montalban.;Kottil W Rammohan.;Krzysztof Selmaj.;Anthony Traboulsee.;Jerry S Wolinsky.;Douglas L Arnold.;Gaelle Klingelschmitt.;Donna Masterman.;Paulo Fontoura.;Shibeshih Belachew.;Peter Chin.;Nicole Mairon.;Hideki Garren.;Ludwig Kappos.; .
来源: N Engl J Med. 2017年376卷3期221-234页
B cells influence the pathogenesis of multiple sclerosis. Ocrelizumab is a humanized monoclonal antibody that selectively depletes CD20+ B cells.
99. Transforming Evidence Generation to Support Health and Health Care Decisions.
作者: Robert M Califf.;Melissa A Robb.;Andrew B Bindman.;Josephine P Briggs.;Francis S Collins.;Patrick H Conway.;Trinka S Coster.;Francesca E Cunningham.;Nancy De Lew.;Karen B DeSalvo.;Christine Dymek.;Victor J Dzau.;Rachael L Fleurence.;Richard G Frank.;J Michael Gaziano.;Petra Kaufmann.;Michael Lauer.;Peter W Marks.;J Michael McGinnis.;Chesley Richards.;Joe V Selby.;David J Shulkin.;Jeffrey Shuren.;Andrew M Slavitt.;Scott R Smith.;B Vindell Washington.;P Jon White.;Janet Woodcock.;Jonathan Woodson.;Rachel E Sherman.
来源: N Engl J Med. 2016年375卷24期2395-2400页 |