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761. Attitudes and Practices of Euthanasia and Physician-Assisted Suicide in the United States, Canada, and Europe.
作者: Ezekiel J Emanuel.;Bregje D Onwuteaka-Philipsen.;John W Urwin.;Joachim Cohen.
来源: JAMA. 2016年316卷1期79-90页
The increasing legalization of euthanasia and physician-assisted suicide worldwide makes it important to understand related attitudes and practices.
762. Association of a Genetic Risk Score With Body Mass Index Across Different Birth Cohorts.
作者: Stefan Walter.;Iván Mejía-Guevara.;Karol Estrada.;Sze Y Liu.;M Maria Glymour.
来源: JAMA. 2016年316卷1期63-9页
Many genetic variants are associated with body mass index (BMI). Associations may have changed with the 20th century obesity epidemic and may differ for black vs white individuals.
763. Effect of Palliative Care-Led Meetings for Families of Patients With Chronic Critical Illness: A Randomized Clinical Trial.
作者: Shannon S Carson.;Christopher E Cox.;Sylvan Wallenstein.;Laura C Hanson.;Marion Danis.;James A Tulsky.;Emily Chai.;Judith E Nelson.
来源: JAMA. 2016年316卷1期51-62页
Family caregivers of patients with chronic critical illness experience significant psychological distress.
764. Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial.
作者: .;Samuel Frank.;Claudia M Testa.;David Stamler.;Elise Kayson.;Charles Davis.;Mary C Edmondson.;Shari Kinel.;Blair Leavitt.;David Oakes.;Christine O'Neill.;Christina Vaughan.;Jody Goldstein.;Margaret Herzog.;Victoria Snively.;Jacquelyn Whaley.;Cynthia Wong.;Greg Suter.;Joseph Jankovic.;Joohi Jimenez-Shahed.;Christine Hunter.;Daniel O Claassen.;Olivia C Roman.;Victor Sung.;Jenna Smith.;Sarah Janicki.;Ronda Clouse.;Marie Saint-Hilaire.;Anna Hohler.;Denyse Turpin.;Raymond C James.;Ramon Rodriguez.;Kyle Rizer.;Karen E Anderson.;Hope Heller.;Alexis Carlson.;Susan Criswell.;Brad A Racette.;Fredy J Revilla.;Frederick Nucifora.;Russell L Margolis.;MaryJane Ong.;Tilak Mendis.;Neila Mendis.;Carlos Singer.;Monica Quesada.;Jane S Paulsen.;Thomas Brashers-Krug.;Amanda Miller.;Jane Kerr.;Richard M Dubinsky.;Carolyn Gray.;Stewart A Factor.;Elaine Sperin.;Eric Molho.;Mary Eglow.;Sharon Evans.;Rajeev Kumar.;Christina Reeves.;Ali Samii.;Sylvain Chouinard.;Monica Beland.;Burton L Scott.;Patrick T Hickey.;Sherali Esmail.;Wai Lun Alan Fung.;Clare Gibbons.;Lina Qi.;Amy Colcher.;Cory Hackmyer.;Andrew McGarry.;Kevin Klos.;Mark Gudesblatt.;Lori Fafard.;Laura Graffitti.;Daniel P Schneider.;Rohit Dhall.;Joanne M Wojcieszek.;Kathrin LaFaver.;Andrew Duker.;Erin Neefus.;Hilary Wilson-Perez.;David Shprecher.;Paola Wall.;Karen A Blindauer.;Lynn Wheeler.;James T Boyd.;Emily Houston.;Eric S Farbman.;Pinky Agarwal.;Shirley W Eberly.;Arthur Watts.;Pierre N Tariot.;Andrew Feigin.;Scott Evans.;Chris Beck.;Constance Orme.;Jon Edicola.;Emily Christopher.
来源: JAMA. 2016年316卷1期40-50页
Deutetrabenazine is a novel molecule containing deuterium, which attenuates CYP2D6 metabolism and increases active metabolite half-lives and may therefore lead to stable systemic exposure while preserving key pharmacological activity.
773. Effect of a Primary Care Management Intervention on Mental Health-Related Quality of Life Among Survivors of Sepsis: A Randomized Clinical Trial.
作者: Konrad Schmidt.;Susanne Worrack.;Michael Von Korff.;Dimitry Davydow.;Frank Brunkhorst.;Ulrike Ehlert.;Christine Pausch.;Juliane Mehlhorn.;Nico Schneider.;André Scherag.;Antje Freytag.;Konrad Reinhart.;Michel Wensing.;Jochen Gensichen.; .
来源: JAMA. 2016年315卷24期2703-11页
Survivors of sepsis face long-term sequelae that diminish health-related quality of life and result in increased care needs in the primary care setting, such as medication, physiotherapy, or mental health care.
774. Effect of Escitalopram on All-Cause Mortality and Hospitalization in Patients With Heart Failure and Depression: The MOOD-HF Randomized Clinical Trial.
作者: Christiane E Angermann.;Götz Gelbrich.;Stefan Störk.;Hilka Gunold.;Frank Edelmann.;Rolf Wachter.;Heribert Schunkert.;Tobias Graf.;Ingrid Kindermann.;Markus Haass.;Stephan Blankenberg.;Sabine Pankuweit.;Christiane Prettin.;Martin Gottwik.;Michael Böhm.;Hermann Faller.;Jürgen Deckert.;Georg Ertl.; .
来源: JAMA. 2016年315卷24期2683-93页
Depression is frequent in patients with heart failure and is associated with adverse clinical outcomes. Long-term efficacy and safety of selective serotonin reuptake inhibitors in these patients are unknown.
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