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621. A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro.
作者: Philipp Schlaermann.;Benjamin Toelle.;Hilmar Berger.;Sven C Schmidt.;Matthias Glanemann.;Jürgen Ordemann.;Sina Bartfeld.;Hans J Mollenkopf.;Thomas F Meyer.
来源: Gut. 2016年65卷2期202-13页
Helicobacter pylori is the causative agent of gastric diseases and the main risk factor in the development of gastric adenocarcinoma. In vitro studies with this bacterial pathogen largely rely on the use of transformed cell lines as infection model. However, this approach is intrinsically artificial and especially inappropriate when it comes to investigating the mechanisms of cancerogenesis. Moreover, common cell lines are often defective in crucial signalling pathways relevant to infection and cancer. A long-lived primary cell system would be preferable in order to better approximate the human in vivo situation.
623. Motilin-induced gastric contractions signal hunger in man.
作者: J Tack.;E Deloose.;D Ang.;E Scarpellini.;T Vanuytsel.;L Van Oudenhove.;I Depoortere.
来源: Gut. 2016年65卷2期214-24页
Hunger is controlled by the brain, which receives input from signals of the GI tract (GIT). During fasting, GIT displays a cyclical motor pattern, the migrating motor complex (MMC), regulated by motilin.
624. Improvement over time in outcomes for patients undergoing endoscopic therapy for Barrett's oesophagus-related neoplasia: 6-year experience from the first 500 patients treated in the UK patient registry.
作者: R J Haidry.;M A Butt.;J M Dunn.;A Gupta.;G Lipman.;H L Smart.;P Bhandari.;L Smith.;R Willert.;G Fullarton.;M Di Pietro.;C Gordon.;I Penman.;H Barr.;P Patel.;N Kapoor.;J Hoare.;R Narayanasamy.;Y Ang.;A Veitch.;K Ragunath.;M Novelli.;L B Lovat.; .
来源: Gut. 2015年64卷8期1192-9页
Barrett's oesophagus (BE) is a pre-malignant condition leading to oesophageal adenocarcinoma (OAC). Treatment of neoplasia at an early stage is desirable. Combined endoscopic mucosal resection (EMR) followed by radiofrequency ablation (RFA) is an alternative to surgery for patients with BE-related neoplasia.
626. Randomised controlled trial of mesalazine in IBS.
作者: Giovanni Barbara.;Cesare Cremon.;Vito Annese.;Guido Basilisco.;Franco Bazzoli.;Massimo Bellini.;Antonio Benedetti.;Luigi Benini.;Fabrizio Bossa.;Paola Buldrini.;Michele Cicala.;Rosario Cuomo.;Bastianello Germanà.;Paola Molteni.;Matteo Neri.;Marcello Rodi.;Alfredo Saggioro.;Maria Lia Scribano.;Maurizio Vecchi.;Giorgio Zoli.;Roberto Corinaldesi.;Vincenzo Stanghellini.
来源: Gut. 2016年65卷1期82-90页
Low-grade intestinal inflammation plays a role in the pathophysiology of IBS. In this trial, we aimed at evaluating the efficacy and safety of mesalazine in patients with IBS.
627. Effects of bowel cleansing on the intestinal microbiota.
作者: Jonna Jalanka.;Anne Salonen.;Jarkko Salojärvi.;Jarmo Ritari.;Outi Immonen.;Luca Marciani.;Penny Gowland.;Caroline Hoad.;Klara Garsed.;Ching Lam.;Airi Palva.;Robin C Spiller.;Willem M de Vos.
来源: Gut. 2015年64卷10期1562-8页
An adequate bowel cleansing is essential for a successful colonoscopy. Although purgative consumption is safe for the patient, there is little consensus on how the intestinal microbiota is affected by the procedure, especially regarding the potential long-term consequences.
628. Additive antitumour response to the rabbit VX2 hepatoma by combined radio frequency ablation and toll like receptor 9 stimulation.
作者: Barbara Behm.;Pietro Di Fazio.;Patrick Michl.;Daniel Neureiter.;Ralf Kemmerling.;Eckhart Georg Hahn.;Deike Strobel.;Thomas Gress.;Detlef Schuppan.;Thaddaeus Till Wissniowski.
来源: Gut. 2016年65卷1期134-43页
Radiofrequency ablation (RFA), a palliative therapeutic option for solid hepatic tumours, stimulates localised and systemic antitumour cytotoxic T cells. We studied how far addition of CpG B oligonucleotides, toll like receptor (TLR) 9 agonists, would increase the antitumoural T cell response of RFA in the highly aggressive VX2 hepatoma.
629. Comparison of colonoscopic performance between medical and nurse endoscopists: a non-inferiority randomised controlled study in Asia.
作者: Aric J Hui.;James Y Lau.;Phyllis P Y Lam.;Alman O M Chui.;Alice S H Fan.;Thomas Y T Lam.;Yee-Kit Tse.;Raymond S Y Tang.;Siew C Ng.;Justin C Y Wu.;Jessica Y L Ching.;Martin C S Wong.;Francis K L Chan.;Joseph Sung.
来源: Gut. 2015年64卷7期1058-62页
To test the hypothesis that trained nurse endoscopists are not inferior to medical endoscopists in finding adenomas during colonoscopy.
631. Value of endoscopy and MRI for predicting intestinal surgery in patients with Crohn's disease in the era of biologics.
作者: A Jauregui-Amezaga.;J Rimola.;I Ordás.;S Rodríguez.;A Ramírez-Morros.;M Gallego.;M C Masamunt.;J Llach.;B González-Suárez.;E Ricart.;J Panés.
来源: Gut. 2015年64卷9期1397-402页
Severe endoscopic lesions (SEL) in patients with colonic Crohn's disease (CD) have been linked to higher risk of colectomy. The aims of this study were to reassess the predictive value of colonoscopy compared against MRI for requirement of resection surgery in patients with CD and determine the influence of current therapeutic options.
632. Glutathione peroxidase 4 is reversibly induced by HCV to control lipid peroxidation and to increase virion infectivity.
作者: Charlène Brault.;Pierre Lévy.;Sarah Duponchel.;Maud Michelet.;Aurèlie Sallé.;Eve-Isabelle Pécheur.;Marie-Laure Plissonnier.;Romain Parent.;Evelyne Véricel.;Alexander V Ivanov.;Münevver Demir.;Hans-Michael Steffen.;Margarete Odenthal.;Fabien Zoulim.;Birke Bartosch.
来源: Gut. 2016年65卷1期144-54页
Inflammation and oxidative stress drive disease progression in chronic hepatitis C (CHC) towards hepatocellular carcinoma. HCV is known to increase intracellular levels of reactive oxygen species (ROS), but how it eliminates ROS is less well known. The role of the ROS scavenger glutathione peroxidase 4 (GPx4), induced by HCV, in the viral life cycle was analysed.
634. Ten-year incidence of colorectal cancer following a negative screening sigmoidoscopy: an update from the Colorectal Cancer Prevention (CoCaP) programme.
作者: V Paul Doria-Rose.;Theodore R Levin.;Albert Palitz.;Carol Conell.;Noel S Weiss.
来源: Gut. 2016年65卷2期271-7页
To examine the rates of colorectal cancer (CRC) following a negative screening sigmoidoscopy.
635. Peripancreatic fat necrosis worsens acute pancreatitis independent of pancreatic necrosis via unsaturated fatty acids increased in human pancreatic necrosis collections.
作者: Pawan Noel.;Krutika Patel.;Chandra Durgampudi.;Ram N Trivedi.;Cristiane de Oliveira.;Michael D Crowell.;Rahul Pannala.;Kenneth Lee.;Randall Brand.;Jennifer Chennat.;Adam Slivka.;Georgios I Papachristou.;Asif Khalid.;David C Whitcomb.;James P DeLany.;Rachel A Cline.;Chathur Acharya.;Deepthi Jaligama.;Faris M Murad.;Dhiraj Yadav.;Sarah Navina.;Vijay P Singh.
来源: Gut. 2016年65卷1期100-11页
Peripancreatic fat necrosis occurs frequently in necrotising pancreatitis. Distinguishing markers from mediators of severe acute pancreatitis (SAP) is important since targeting mediators may improve outcomes. We evaluated potential agents in human pancreatic necrotic collections (NCs), pseudocysts (PCs) and pancreatic cystic neoplasms and used pancreatic acini, peripheral blood mononuclear cells (PBMC) and an acute pancreatitis (AP) model to determine SAP mediators.
636. KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins.
作者: Giusi Marrone.;Raquel Maeso-Díaz.;Guillermo García-Cardena.;Juan G Abraldes.;Juan Carlos García-Pagán.;Jaime Bosch.;Jordi Gracia-Sancho.
来源: Gut. 2015年64卷9期1434-43页
In the liver, the transcription factor, Kruppel-like factor 2 (KLF2), is induced early during progression of cirrhosis to lessen the development of vascular dysfunction; nevertheless, its endogenous expression results insufficient to attenuate establishment of portal hypertension and aggravation of cirrhosis. Herein, we aimed to explore the effects and the underlying mechanisms of hepatic KLF2 overexpression in in vitro and in vivo models of liver cirrhosis.
637. Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults.
作者: Edward S Chambers.;Alexander Viardot.;Arianna Psichas.;Douglas J Morrison.;Kevin G Murphy.;Sagen E K Zac-Varghese.;Kenneth MacDougall.;Tom Preston.;Catriona Tedford.;Graham S Finlayson.;John E Blundell.;Jimmy D Bell.;E Louise Thomas.;Shahrul Mt-Isa.;Deborah Ashby.;Glen R Gibson.;Sofia Kolida.;Waljit S Dhillo.;Stephen R Bloom.;Wayne Morley.;Stuart Clegg.;Gary Frost.
来源: Gut. 2015年64卷11期1744-54页
The colonic microbiota ferment dietary fibres, producing short chain fatty acids. Recent evidence suggests that the short chain fatty acid propionate may play an important role in appetite regulation. We hypothesised that colonic delivery of propionate would increase peptide YY (PYY) and glucagon like peptide-1 (GLP-1) secretion in humans, and reduce energy intake and weight gain in overweight adults.
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