605. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 26-2016. A 28-Year-Old Woman with Back Pain and a Lesion in the Lumbar Spine.
作者: Edwin Choy.;Francis J Hornicek.;Yen-Lin Chen.;Daniel I Rosenthal.;Darcy A Kerr.
来源: N Engl J Med. 2016年375卷8期779-88页 608. Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma.
作者: Antonio Palumbo.;Asher Chanan-Khan.;Katja Weisel.;Ajay K Nooka.;Tamas Masszi.;Meral Beksac.;Ivan Spicka.;Vania Hungria.;Markus Munder.;Maria V Mateos.;Tomer M Mark.;Ming Qi.;Jordan Schecter.;Himal Amin.;Xiang Qin.;William Deraedt.;Tahamtan Ahmadi.;Andrew Spencer.;Pieter Sonneveld.; .
来源: N Engl J Med. 2016年375卷8期754-66页
Daratumumab, a human IgGκ monoclonal antibody that targets CD38, induces direct and indirect antimyeloma activity and has shown substantial efficacy as monotherapy in heavily pretreated patients with multiple myeloma, as well as in combination with bortezomib in patients with newly diagnosed multiple myeloma.
609. A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor.
作者: W Jeffrey Elias.;Nir Lipsman.;William G Ondo.;Pejman Ghanouni.;Young G Kim.;Wonhee Lee.;Michael Schwartz.;Kullervo Hynynen.;Andres M Lozano.;Binit B Shah.;Diane Huss.;Robert F Dallapiazza.;Ryder Gwinn.;Jennifer Witt.;Susie Ro.;Howard M Eisenberg.;Paul S Fishman.;Dheeraj Gandhi.;Casey H Halpern.;Rosalind Chuang.;Kim Butts Pauly.;Travis S Tierney.;Michael T Hayes.;G Rees Cosgrove.;Toshio Yamaguchi.;Keiichi Abe.;Takaomi Taira.;Jin W Chang.
来源: N Engl J Med. 2016年375卷8期730-9页
Uncontrolled pilot studies have suggested the efficacy of focused ultrasound thalamotomy with magnetic resonance imaging (MRI) guidance for the treatment of essential tremor.
610. 70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer.
作者: Fatima Cardoso.;Laura J van't Veer.;Jan Bogaerts.;Leen Slaets.;Giuseppe Viale.;Suzette Delaloge.;Jean-Yves Pierga.;Etienne Brain.;Sylvain Causeret.;Mauro DeLorenzi.;Annuska M Glas.;Vassilis Golfinopoulos.;Theodora Goulioti.;Susan Knox.;Erika Matos.;Bart Meulemans.;Peter A Neijenhuis.;Ulrike Nitz.;Rodolfo Passalacqua.;Peter Ravdin.;Isabel T Rubio.;Mahasti Saghatchian.;Tineke J Smilde.;Christos Sotiriou.;Lisette Stork.;Carolyn Straehle.;Geraldine Thomas.;Alastair M Thompson.;Jacobus M van der Hoeven.;Peter Vuylsteke.;René Bernards.;Konstantinos Tryfonidis.;Emiel Rutgers.;Martine Piccart.; .
来源: N Engl J Med. 2016年375卷8期717-29页
The 70-gene signature test (MammaPrint) has been shown to improve prediction of clinical outcome in women with early-stage breast cancer. We sought to provide prospective evidence of the clinical utility of the addition of the 70-gene signature to standard clinical-pathological criteria in selecting patients for adjuvant chemotherapy.
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