当前位置: 首页 >> 检索结果
50. Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy.
作者: Christine E Brown.;Darya Alizadeh.;Renate Starr.;Lihong Weng.;Jamie R Wagner.;Araceli Naranjo.;Julie R Ostberg.;M Suzette Blanchard.;Julie Kilpatrick.;Jennifer Simpson.;Anita Kurien.;Saul J Priceman.;Xiuli Wang.;Todd L Harshbarger.;Massimo D'Apuzzo.;Julie A Ressler.;Michael C Jensen.;Michael E Barish.;Mike Chen.;Jana Portnow.;Stephen J Forman.;Behnam Badie.
来源: N Engl J Med. 2016年375卷26期2561-9页
A patient with recurrent multifocal glioblastoma received chimeric antigen receptor (CAR)-engineered T cells targeting the tumor-associated antigen interleukin-13 receptor alpha 2 (IL13Rα2). Multiple infusions of CAR T cells were administered over 220 days through two intracranial delivery routes - infusions into the resected tumor cavity followed by infusions into the ventricular system. Intracranial infusions of IL13Rα2-targeted CAR T cells were not associated with any toxic effects of grade 3 or higher. After CAR T-cell treatment, regression of all intracranial and spinal tumors was observed, along with corresponding increases in levels of cytokines and immune cells in the cerebrospinal fluid. This clinical response continued for 7.5 months after the initiation of CAR T-cell therapy. (Funded by Gateway for Cancer Research and others; ClinicalTrials.gov number, NCT02208362 .).
51. Fish Oil-Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring.
作者: Hans Bisgaard.;Jakob Stokholm.;Bo L Chawes.;Nadja H Vissing.;Elin Bjarnadóttir.;Ann-Marie M Schoos.;Helene M Wolsk.;Tine M Pedersen.;Rebecca K Vinding.;Sunna Thorsteinsdóttir.;Nilofar V Følsgaard.;Nadia R Fink.;Jonathan Thorsen.;Anders G Pedersen.;Johannes Waage.;Morten A Rasmussen.;Ken D Stark.;Sjurdur F Olsen.;Klaus Bønnelykke.
来源: N Engl J Med. 2016年375卷26期2530-9页
Reduced intake of n-3 long-chain polyunsaturated fatty acids (LCPUFAs) may be a contributing factor to the increasing prevalence of wheezing disorders. We assessed the effect of supplementation with n-3 LCPUFAs in pregnant women on the risk of persistent wheeze and asthma in their offspring.
59. Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas.
作者: Eva Dombi.;Andrea Baldwin.;Leigh J Marcus.;Michael J Fisher.;Brian Weiss.;AeRang Kim.;Patricia Whitcomb.;Staci Martin.;Lindsey E Aschbacher-Smith.;Tilat A Rizvi.;Jianqiang Wu.;Rachel Ershler.;Pamela Wolters.;Janet Therrien.;John Glod.;Jean B Belasco.;Elizabeth Schorry.;Alessandra Brofferio.;Amy J Starosta.;Andrea Gillespie.;Austin L Doyle.;Nancy Ratner.;Brigitte C Widemann.
来源: N Engl J Med. 2016年375卷26期2550-2560页
Effective medical therapies are lacking for the treatment of neurofibromatosis type 1-related plexiform neurofibromas, which are characterized by elevated RAS-mitogen-activated protein kinase (MAPK) signaling.
|