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572. Acute Aortic Dissection and Intramural Hematoma: A Systematic Review.
作者: Firas F Mussa.;Joshua D Horton.;Rameen Moridzadeh.;Joseph Nicholson.;Santi Trimarchi.;Kim A Eagle.
来源: JAMA. 2016年316卷7期754-63页
Acute aortic syndrome (AAS), a potentially fatal pathologic process within the aortic wall, should be suspected in patients presenting with severe thoracic pain and hypertension. AAS, including aortic dissection (approximately 90% of cases) and intramural hematoma, may be complicated by poor perfusion, aneurysm, or uncontrollable pain and hypertension. AAS is uncommon (approximately 3.5-6.0 per 100,000 patient-years) but rapid diagnosis is imperative as an emergency surgical procedure is frequently necessary.
573. Cost-effectiveness of PCSK9 Inhibitor Therapy in Patients With Heterozygous Familial Hypercholesterolemia or Atherosclerotic Cardiovascular Disease.
作者: Dhruv S Kazi.;Andrew E Moran.;Pamela G Coxson.;Joanne Penko.;Daniel A Ollendorf.;Steven D Pearson.;Jeffrey A Tice.;David Guzman.;Kirsten Bibbins-Domingo.
来源: JAMA. 2016年316卷7期743-53页
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors were recently approved for lowering low-density lipoprotein cholesterol in heterozygous familial hypercholesterolemia (FH) or atherosclerotic cardiovascular disease (ASCVD) and have potential for broad ASCVD prevention. Their long-term cost-effectiveness and effect on total health care spending are uncertain.
574. Modeled Fetal Risk of Genetic Diseases Identified by Expanded Carrier Screening.
作者: Imran S Haque.;Gabriel A Lazarin.;H Peter Kang.;Eric A Evans.;James D Goldberg.;Ronald J Wapner.
来源: JAMA. 2016年316卷7期734-42页
Screening for carrier status of a limited number of single-gene conditions is the current standard of prenatal care. Methods have become available allowing rapid expanded carrier screening for a substantial number of conditions.
575. Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical Trial.
作者: Paul D Miller.;Gary Hattersley.;Bente Juel Riis.;Gregory C Williams.;Edith Lau.;Luis Augusto Russo.;Peter Alexandersen.;Cristiano A F Zerbini.;Ming-yi Hu.;Alan G Harris.;Lorraine A Fitzpatrick.;Felicia Cosman.;Claus Christiansen.; .
来源: JAMA. 2016年316卷7期722-33页
Additional therapies are needed for prevention of osteoporotic fractures. Abaloparatide is a selective activator of the parathyroid hormone type 1 receptor.
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