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462. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 29-2016. A 53-Year-Old Woman with Pain and a Mass in the Breast.
作者: Katherine T Johnston.;Pragya A Dang.;Michelle C Specht.;Alyssa R Letourneau.;Thomas M Gudewicz.
来源: N Engl J Med. 2016年375卷12期1172-80页 465. Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria.
作者: Nicholas J White.;Tran T Duong.;Chirapong Uthaisin.;François Nosten.;Aung P Phyo.;Borimas Hanboonkunupakarn.;Sasithon Pukrittayakamee.;Podjanee Jittamala.;Kittiphum Chuthasmit.;Ming S Cheung.;Yiyan Feng.;Ruobing Li.;Baldur Magnusson.;Marc Sultan.;Daniela Wieser.;Xiaolei Xun.;Rong Zhao.;Thierry T Diagana.;Peter Pertel.;F Joel Leong.
来源: N Engl J Med. 2016年375卷12期1152-60页
KAF156 belongs to a new class of antimalarial agents (imidazolopiperazines), with activity against asexual and sexual blood stages and the preerythrocytic liver stages of malarial parasites.
466. Nasal High-Flow Therapy for Primary Respiratory Support in Preterm Infants.
作者: Calum T Roberts.;Louise S Owen.;Brett J Manley.;Dag H Frøisland.;Susan M Donath.;Kim M Dalziel.;Margo A Pritchard.;David W Cartwright.;Clare L Collins.;Atul Malhotra.;Peter G Davis.; .
来源: N Engl J Med. 2016年375卷12期1142-51页
Treatment with nasal high-flow therapy has efficacy similar to that of nasal continuous positive airway pressure (CPAP) when used as postextubation support in neonates. The efficacy of high-flow therapy as the primary means of respiratory support for preterm infants with respiratory distress has not been proved.
471. The Role of PIEZO2 in Human Mechanosensation.
作者: Alexander T Chesler.;Marcin Szczot.;Diana Bharucha-Goebel.;Marta Čeko.;Sandra Donkervoort.;Claire Laubacher.;Leslie H Hayes.;Katharine Alter.;Cristiane Zampieri.;Christopher Stanley.;A Micheil Innes.;Jean K Mah.;Carla M Grosmann.;Nathaniel Bradley.;David Nguyen.;A Reghan Foley.;Claire E Le Pichon.;Carsten G Bönnemann.
来源: N Engl J Med. 2016年375卷14期1355-1364页
The senses of touch and proprioception evoke a range of perceptions and rely on the ability to detect and transduce mechanical force. The molecular and neural mechanisms underlying these sensory functions remain poorly defined. The stretch-gated ion channel PIEZO2 has been shown to be essential for aspects of mechanosensation in model organisms.
473. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.
作者: Steven P Marso.;Stephen C Bain.;Agostino Consoli.;Freddy G Eliaschewitz.;Esteban Jódar.;Lawrence A Leiter.;Ildiko Lingvay.;Julio Rosenstock.;Jochen Seufert.;Mark L Warren.;Vincent Woo.;Oluf Hansen.;Anders G Holst.;Jonas Pettersson.;Tina Vilsbøll.; .
来源: N Engl J Med. 2016年375卷19期1834-1844页
Regulatory guidance specifies the need to establish cardiovascular safety of new diabetes therapies in patients with type 2 diabetes in order to rule out excess cardiovascular risk. The cardiovascular effects of semaglutide, a glucagon-like peptide 1 analogue with an extended half-life of approximately 1 week, in type 2 diabetes are unknown.
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