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401. Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice.
作者: Koen Vercauteren.;Richard J P Brown.;Ahmed Atef Mesalam.;Juliane Doerrbecker.;Sabin Bhuju.;Robert Geffers.;Naomi Van Den Eede.;C Patrick McClure.;Fulvia Troise.;Lieven Verhoye.;Thomas Baumert.;Ali Farhoudi.;Riccardo Cortese.;Jonathan K Ball.;Geert Leroux-Roels.;Thomas Pietschmann.;Alfredo Nicosia.;Philip Meuleman.
来源: Gut. 2016年65卷12期2029-2034页
Direct-acting antivirals (DAAs) inhibit hepatitis C virus (HCV) infection by targeting viral proteins that play essential roles in the replication process. However, selection of resistance-associated variants (RAVs) during DAA therapy has been a cause of therapeutic failure. In this study, we wished to address whether such RAVs could be controlled by the co-administration of host-targeting entry inhibitors that prevent intrahepatic viral spread.
402. Appropriateness of endoscopic surveillance recommendations in organised colorectal cancer screening programmes based on the faecal immunochemical test.
作者: Manuel Zorzi.;Carlo Senore.;Anna Turrin.;Paola Mantellini.;Carmen Beatriz Visioli.;Carlo Naldoni.;Priscilla Sassoli De' Bianchi.;Chiara Fedato.;Emanuela Anghinoni.;Marco Zappa.;Cesare Hassan.; .
来源: Gut. 2016年65卷11期1822-1828页
To assess the appropriateness of recommendations for endoscopic surveillance in organised colorectal cancer (CRC) screening programmes based on the faecal immunochemical test (FIT).
404. Faecal haemoglobin and faecal calprotectin as indicators of bowel disease in patients presenting to primary care with bowel symptoms.
作者: Craig Mowat.;Jayne Digby.;Judith A Strachan.;Robyn Wilson.;Francis A Carey.;Callum G Fraser.;Robert J C Steele.
来源: Gut. 2016年65卷9期1463-9页
In primary care, assessing which patients with bowel symptoms harbour significant disease (cancer, higher-risk adenoma or IBD) is difficult. We studied the diagnostic accuracies of faecal haemoglobin (FHb) and faecal calprotectin (FC) in a cohort of symptomatic patients.
405. Hypermethylation of ZNF545 is associated with poor prognosis in patients with early-stage hepatocellular carcinoma after thermal ablation.
作者: Jie Yu.;Xin Li.;Qian Tao.;Xiao-Ling Yu.;Zhi-Gang Cheng.;Zhi-Yu Han.;Mingzhou Guo.;Ping Liang.
来源: Gut. 2015年64卷11期1836-7页 406. MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway.
Non-alcoholic fatty liver disease (NAFLD) is a major risk factor for hepatocellular carcinoma (HCC). However, the mechanistic pathways that link both disorders are essentially unknown.
407. Prospective evaluation of endoscopic ultrasonography-guided double-balloon-occluded gastrojejunostomy bypass (EPASS) for malignant gastric outlet obstruction.
作者: Takao Itoi.;Kentaro Ishii.;Nobuhito Ikeuchi.;Atsushi Sofuni.;Takuji Gotoda.;Fuminori Moriyasu.;Vinay Dhir.;Anthony Yuen Bin Teoh.;Kenneth F Binmoeller.
来源: Gut. 2016年65卷2期193-5页 408. Host cell mTORC1 is required for HCV RNA replication.
作者: Stefanie Stöhr.;Rui Costa.;Lisa Sandmann.;Sandra Westhaus.;Stephanie Pfaender.; Anggakusuma.;Eva Dazert.;Philip Meuleman.;Florian W R Vondran.;Michael P Manns.;Eike Steinmann.;Thomas von Hahn.;Sandra Ciesek.
来源: Gut. 2016年65卷12期2017-2028页
Chronically HCV-infected orthotopic liver transplantation (OLT) recipients appear to have improved outcomes when their immunosuppressive regimen includes a mammalian target of rapamycin (mTOR) inhibitor. The mechanism underlying this observation is unknown.
413. Colorectal cancer risk factors in patients with serrated polyposis syndrome: a large multicentre study.
作者: Sabela Carballal.;Daniel Rodríguez-Alcalde.;Leticia Moreira.;Luis Hernández.;Lorena Rodríguez.;Francisco Rodríguez-Moranta.;Victoria Gonzalo.;Luis Bujanda.;Xavier Bessa.;Carmen Poves.;Joaquin Cubiella.;Inés Castro.;Mariano González.;Eloísa Moya.;Susana Oquiñena.;Joan Clofent.;Enrique Quintero.;Pilar Esteban.;Virginia Piñol.;Francisco Javier Fernández.;Rodrigo Jover.;Lucía Cid.;María López-Cerón.;Miriam Cuatrecasas.;Jorge López-Vicente.;Maria Liz Leoz.;Liseth Rivero-Sánchez.;Antoni Castells.;María Pellisé.;Francesc Balaguer.; .
来源: Gut. 2016年65卷11期1829-1837页
Serrated polyposis syndrome (SPS) is associated with an increased colorectal cancer (CRC) risk, although the magnitude of the risk remains uncertain. Whereas intensive endoscopic surveillance for CRC prevention is advised, predictors that identify patients who have high CRC risk remain unknown. We performed a multicentre nationwide study aimed at describing the CRC risk in patients with SPS and identifying clinicopathological predictors independently associated with CRC.
415. Severe intestinal malabsorption associated with olmesartan: a French nationwide observational cohort study.
作者: Mickael Basson.;Myriam Mezzarobba.;Alain Weill.;Philippe Ricordeau.;Hubert Allemand.;Francois Alla.;Franck Carbonnel.
来源: Gut. 2016年65卷10期1664-9页
Severe sprue-like enteropathy associated with olmesartan has been reported, but there has been no demonstration of an increased risk by epidemiological studies.
418. Identification of a functional PRSS1 promoter variant in linkage disequilibrium with the chronic pancreatitis-protecting rs10273639.
作者: Arnaud Boulling.;Masahiro Sato.;Emmanuelle Masson.;Emmanuelle Génin.;Jian-Min Chen.;Claude Férec.
来源: Gut. 2015年64卷11期1837-8页 419. A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion.
IBD is characterised by dysregulated intestinal immune homeostasis and cytokine secretion. In the intestine, properly regulating pattern recognition receptor (PRR)-mediated signalling and cytokines is crucial given the ongoing host-microbial interactions. TPL2 (MAP3K8, COT) contributes to PRR-initiated pathways, yet the mechanisms for TPL2 signalling contributions in primary human myeloid cells are incompletely understood and its role in intestinal myeloid cells is poorly defined. Furthermore, functional consequences for the IBD-risk locus rs1042058 in TPL2 are unknown.
420. Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo.
作者: Anika Fischer.;Sebastian Zundler.;Raja Atreya.;Timo Rath.;Caroline Voskens.;Simon Hirschmann.;Rocío López-Posadas.;Alastair Watson.;Christoph Becker.;Gerold Schuler.;Clemens Neufert.;Imke Atreya.;Markus F Neurath.
来源: Gut. 2016年65卷10期1642-64页
Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in IBDs. We aimed to analyse the in vivo homing of effector (Teff) and regulatory (Treg) T cells to the inflamed gut via α4β7 and G protein receptor GPR15.
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