当前位置: 首页 >> 检索结果
21. The prognostic influence of body mass index, resting energy expenditure and fasting blood glucose on postoperative patients with esophageal cancer.
作者: Ning Wu.;Yongjun Zhu.;Dhruba Kadel.;Liewen Pang.;Gang Chen.;Zhiming Chen.
来源: BMC Gastroenterol. 2016年16卷1期142页
Body mass index (BMI), resting energy expenditure (REE) and fasting blood glucose (FBG) are major preoperative assessments of patients' nutrition and metabolic state. The relations and effects of these indices on esophageal cancer patients' postoperative short-term and long-term outcomes remain controversial and unclear. We aimed to study the impact of BMI, REE and FBG in esophageal cancer patients undergoing esophagectomy.
22. Smoking influences the need for surgery in patients with the inflammatory bowel diseases: a systematic review and meta-analysis incorporating disease duration.
作者: M Ellen Kuenzig.;Sang Min Lee.;Bertus Eksteen.;Cynthia H Seow.;Cheryl Barnabe.;Remo Panaccione.;Gilaad G Kaplan.
来源: BMC Gastroenterol. 2016年16卷1期143页
Studies examining the association between smoking and the need for surgery in patients with Crohn's disease and ulcerative colitis have reached inconsistent conclusions. These studies often do not differentiate between patients undergoing early surgery and patients having surgery later in their disease course. Our study examined the association between smoking status and time to first bowel resection in patients with Crohn's disease and ulcerative colitis.
23. Nutritional Wheat Amylase-Trypsin Inhibitors Promote Intestinal Inflammation via Activation of Myeloid Cells.
作者: Victor F Zevallos.;Verena Raker.;Stefan Tenzer.;Carolina Jimenez-Calvente.;Muhammad Ashfaq-Khan.;Nina Rüssel.;Geethanjali Pickert.;Hansjörg Schild.;Kerstin Steinbrink.;Detlef Schuppan.
来源: Gastroenterology. 2017年152卷5期1100-1113.e12页
Wheat amylase-trypsin inhibitors (ATIs) are nutritional activators of innate immunity, via activation of the toll-like receptor 4 (TLR4) on myeloid cells. We aimed to characterize the biologic activity of ATIs in various foods and their effect on intestinal inflammation.
24. Low Risk of High-Grade Dysplasia or Esophageal Adenocarcinoma Among Patients With Barrett's Esophagus Less Than 1 cm (Irregular Z Line) Within 5 Years of Index Endoscopy.
作者: Prashanthi N Thota.;Prashanth Vennalaganti.;Sreekar Vennelaganti.;Patrick Young.;Srinivas Gaddam.;Neil Gupta.;David Lieberman.;Richard Sampliner.;Gary W Falk.;Sharad Mathur.;Kevin Kennedy.;Brooks D Cash.;Fouad Moawad.;Ajay Bansal.;Manon C Spaander.;Marco J Bruno.;John Vargo.;Prateek Sharma.
来源: Gastroenterology. 2017年152卷5期987-992页
Many patients with a < 1 cm segment of columnar metaplasia in the distal esophagus, also called an irregular Z line, are encountered. These patients, often referred to as patients with Barrett's esophagus (BE), are enrolled in surveillance programs. However, little is known about their risk of high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). We aimed to determine the incidence of HGD and EAC in patients with irregular Z line with intestinal metaplasia.
25. The Vagus Nerve in Appetite Regulation, Mood, and Intestinal Inflammation.
作者: Kirsteen N Browning.;Simon Verheijden.;Guy E Boeckxstaens.
来源: Gastroenterology. 2017年152卷4期730-744页
Although the gastrointestinal tract contains intrinsic neural plexuses that allow a significant degree of independent control over gastrointestinal functions, the central nervous system provides extrinsic neural inputs that modulate, regulate, and integrate these functions. In particular, the vagus nerve provides the parasympathetic innervation to the gastrointestinal tract, coordinating the complex interactions between central and peripheral neural control mechanisms. This review discusses the physiological roles of the afferent (sensory) and motor (efferent) vagus in regulation of appetite, mood, and the immune system, as well as the pathophysiological outcomes of vagus nerve dysfunction resulting in obesity, mood disorders, and inflammation. The therapeutic potential of vagus nerve modulation to attenuate or reverse these pathophysiological outcomes and restore autonomic homeostasis is also discussed.
31. Milk Fat Globule-EGF Factor 8, Secreted by Mesenchymal Stem Cells, Protects Against Liver Fibrosis in Mice.
作者: Su Yeon An.;Yu Jin Jang.;Hee-Joung Lim.;Jiyou Han.;Jaehun Lee.;Gyunggyu Lee.;Ji Young Park.;Seo-Young Park.;Ji Hyang Kim.;Byung-Rok Do.;Choongseong Han.;Hee-Kyung Park.;Ok-Hee Kim.;Myeong Jun Song.;Say-June Kim.;Jong-Hoon Kim.
来源: Gastroenterology. 2017年152卷5期1174-1186页
Mesenchymal stem cells (MSCs) mediate tissue repair and might be used to prevent or reduce liver fibrosis. However, little is known about the anti-fibrotic factors secreted from MSCs or their mechanisms.
32. Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice.
作者: Chun-Qing Song.;Yingxiang Li.;Haiwei Mou.;Jill Moore.;Angela Park.;Yotsawat Pomyen.;Soren Hough.;Zachary Kennedy.;Andrew Fischer.;Hao Yin.;Daniel G Anderson.;Darryl Conte.;Lars Zender.;Xin Wei Wang.;Snorri Thorgeirsson.;Zhiping Weng.;Wen Xue.
来源: Gastroenterology. 2017年152卷5期1161-1173.e1页
It has been a challenge to identify liver tumor suppressors or oncogenes due to the genetic heterogeneity of these tumors. We performed a genome-wide screen to identify suppressors of liver tumor formation in mice, using CRISPR-mediated genome editing.
33. Analysis of association between circulating miR-122 and histopathological features of nonalcoholic fatty liver disease in patients free of hepatocellular carcinoma.
作者: Norio Akuta.;Yusuke Kawamura.;Fumitaka Suzuki.;Satoshi Saitoh.;Yasuji Arase.;Shunichiro Fujiyama.;Hitomi Sezaki.;Tetsuya Hosaka.;Masahiro Kobayashi.;Yoshiyuki Suzuki.;Mariko Kobayashi.;Kenji Ikeda.;Hiromitsu Kumada.
来源: BMC Gastroenterol. 2016年16卷1期141页
The association between circulating microRNA-122 (miR-122) and histopathological features of nonalcoholic fatty liver disease (NAFLD) remains unclear.
34. Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.
作者: Jean-Charles Nault.;Gabrielle Couchy.;Charles Balabaud.;Guillaume Morcrette.;Stefano Caruso.;Jean-Frederic Blanc.;Yannick Bacq.;Julien Calderaro.;Valérie Paradis.;Jeanne Ramos.;Jean-Yves Scoazec.;Viviane Gnemmi.;Nathalie Sturm.;Catherine Guettier.;Monique Fabre.;Eric Savier.;Laurence Chiche.;Philippe Labrune.;Janick Selves.;Dominique Wendum.;Camilla Pilati.;Alexis Laurent.;Anne De Muret.;Brigitte Le Bail.;Sandra Rebouissou.;Sandrine Imbeaud.; .;Paulette Bioulac-Sage.;Eric Letouzé.;Jessica Zucman-Rossi.
来源: Gastroenterology. 2017年152卷4期880-894.e6页
Hepatocellular adenomas (HCAs) are benign liver tumors that can be assigned to molecular subtypes based on inactivating mutations in hepatocyte nuclear factor 1A, activating mutations in β-catenin, or activation of inflammatory signaling pathways. We aimed to update the classification system for HCA and associate the subtypes with disease risk factors and complications.
35. Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach.
作者: Joseph Burclaff.;Luciana H Osaki.;Dengqun Liu.;James R Goldenring.;Jason C Mills.
来源: Gastroenterology. 2017年152卷4期762-766.e7页
Parietal cell atrophy is considered to cause metaplasia in the stomach. We developed mice that express the diphtheria toxin receptor specifically in parietal cells to induce their death, and found this to increase proliferation in the normal stem cell zone and neck but not to cause metaplastic reprogramming of chief cells. Furthermore, the metaplasia-inducing agents tamoxifen or DMP-777 still induced metaplasia even after previous destruction of parietal cells by diphtheria toxin. Atrophy of parietal cells alone therefore is not sufficient to induce metaplasia: completion of metaplastic reprogramming of chief cells requires mechanisms beyond parietal cell injury or death.
36. Daclatasvir Prevents Hepatitis C Virus Infectivity by Blocking Transfer of the Viral Genome to Assembly Sites.
作者: Bertrand Boson.;Solène Denolly.;Fanny Turlure.;Christophe Chamot.;Marlène Dreux.;François-Loïc Cosset.
来源: Gastroenterology. 2017年152卷4期895-907.e14页
Daclatasvir is a direct-acting antiviral agent and potent inhibitor of NS5A, which is involved in replication of the hepatitis C virus (HCV) genome, presumably via membranous web shaping, and assembly of new virions, likely via transfer of the HCV RNA genome to viral particle assembly sites. Daclatasvir inhibits the formation of new membranous web structures and, ultimately, of replication complex vesicles, but also inhibits an early assembly step. We investigated the relationship between daclatasvir-induced clustering of HCV proteins, intracellular localization of viral RNAs, and inhibition of viral particle assembly.
37. A Clinical Prediction Model to Assess Risk for Pancreatic Cancer Among Patients With New-Onset Diabetes.
作者: Ben Boursi.;Brian Finkelman.;Bruce J Giantonio.;Kevin Haynes.;Anil K Rustgi.;Andrew D Rhim.;Ronac Mamtani.;Yu-Xiao Yang.
来源: Gastroenterology. 2017年152卷4期840-850.e3页
Approximately 50% of all patients with pancreatic ductal adenocarcinoma (PDA) develop diabetes mellitus before their cancer diagnosis. Screening individuals with new-onset diabetes might allow earlier diagnosis of PDA. We sought to develop and validate a PDA risk prediction model to identify high-risk individuals among those with new-onset diabetes.
39. Prevalence and Morbidity of Undiagnosed Celiac Disease From a Community-Based Study.
作者: Rok Seon Choung.;Scott A Larson.;Shahryar Khaleghi.;Alberto Rubio-Tapia.;Inna G Ovsyannikova.;Katherine S King.;Joseph J Larson.;Brian D Lahr.;Gregory A Poland.;Michael J Camilleri.;Joseph A Murray.
来源: Gastroenterology. 2017年152卷4期830-839.e5页
Little is known about the prevalence and burden of undiagnosed celiac disease in individuals younger than age 50. We determined the prevalence and morbidity of undiagnosed celiac disease in individuals younger than age 50 in a community.
40. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease.
作者: Charlie C Park.;Phirum Nguyen.;Carolyn Hernandez.;Ricki Bettencourt.;Kimberly Ramirez.;Lynda Fortney.;Jonathan Hooker.;Ethan Sy.;Michael T Savides.;Mosab H Alquiraish.;Mark A Valasek.;Emily Rizo.;Lisa Richards.;David Brenner.;Claude B Sirlin.;Rohit Loomba.
来源: Gastroenterology. 2017年152卷3期598-607.e2页
Magnetic resonance imaging (MRI) techniques and ultrasound-based transient elastography (TE) can be used in noninvasive diagnosis of fibrosis and steatosis in patients with nonalcoholic fatty liver disease (NAFLD). We performed a prospective study to compare the performance of magnetic resonance elastography (MRE) vs TE for diagnosis of fibrosis, and MRI-based proton density fat fraction (MRI-PDFF) analysis vs TE-based controlled attenuation parameter (CAP) for diagnosis of steatosis in patients undergoing biopsy to assess NAFLD.
|