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368. Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review.
作者: Catherine McParlin.;Amy O'Donnell.;Stephen C Robson.;Fiona Beyer.;Eoin Moloney.;Andrew Bryant.;Jennifer Bradley.;Colin R Muirhead.;Catherine Nelson-Piercy.;Dorothy Newbury-Birch.;Justine Norman.;Caroline Shaw.;Emma Simpson.;Brian Swallow.;Laura Yates.;Luke Vale.
来源: JAMA. 2016年316卷13期1392-1401页
Nausea and vomiting affects approximately 85% of pregnant women. The most severe form, hyperemesis gravidarum, affects up to 3% of women and can have significant adverse physical and psychological sequelae.
371. OnabotulinumtoxinA vs Sacral Neuromodulation on Refractory Urgency Urinary Incontinence in Women: A Randomized Clinical Trial.
作者: Cindy L Amundsen.;Holly E Richter.;Shawn A Menefee.;Yuko M Komesu.;Lily A Arya.;W Thomas Gregory.;Deborah L Myers.;Halina M Zyczynski.;Sandip Vasavada.;Tracy L Nolen.;Dennis Wallace.;Susan F Meikle.
来源: JAMA. 2016年316卷13期1366-1374页
Women with refractory urgency urinary incontinence are treated with sacral neuromodulation and onabotulinumtoxinA with limited comparative information.
372. Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis.
作者: Luca A Lotta.;Stephen J Sharp.;Stephen Burgess.;John R B Perry.;Isobel D Stewart.;Sara M Willems.;Jian'an Luan.;Eva Ardanaz.;Larraitz Arriola.;Beverley Balkau.;Heiner Boeing.;Panos Deloukas.;Nita G Forouhi.;Paul W Franks.;Sara Grioni.;Rudolf Kaaks.;Timothy J Key.;Carmen Navarro.;Peter M Nilsson.;Kim Overvad.;Domenico Palli.;Salvatore Panico.;Jose-Ramón Quirós.;Elio Riboli.;Olov Rolandsson.;Carlotta Sacerdote.;Elena C Salamanca.;Nadia Slimani.;Annemieke Mw Spijkerman.;Anne Tjonneland.;Rosario Tumino.;Daphne L van der A.;Yvonne T van der Schouw.;Mark I McCarthy.;Inês Barroso.;Stephen O'Rahilly.;David B Savage.;Naveed Sattar.;Claudia Langenberg.;Robert A Scott.;Nicholas J Wareham.
来源: JAMA. 2016年316卷13期1383-1391页
Low-density lipoprotein cholesterol (LDL-C)-lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and statins, have previously been used as proxies to study the efficacy of these lipid-lowering drugs. Alleles near HMGCR are associated with a higher risk of type 2 diabetes, similar to the increased incidence of new-onset diabetes associated with statin treatment in randomized clinical trials. It is unknown whether alleles near NPC1L1 are associated with the risk of type 2 diabetes.
373. Association Between Therapeutic Hypothermia and Survival After In-Hospital Cardiac Arrest.
作者: Paul S Chan.;Robert A Berg.;Yuanyuan Tang.;Lesley H Curtis.;John A Spertus.; .
来源: JAMA. 2016年316卷13期1375-1382页
Therapeutic hypothermia is used for patients following both out-of-hospital and in-hospital cardiac arrest. However, randomized trials on its efficacy for the in-hospital setting do not exist, and comparative effectiveness data are limited.
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