323. Long-term Recurrence and Complications Associated With Elective Incisional Hernia Repair.
Prosthetic mesh is frequently used to reinforce the repair of abdominal wall incisional hernias. The benefits of mesh for reducing the risk of hernia recurrence or the long-term risks of mesh-related complications are not known.
325. Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida Colonization, and Multiple Organ Failure: The EMPIRICUS Randomized Clinical Trial.
作者: Jean-Francois Timsit.;Elie Azoulay.;Carole Schwebel.;Pierre Emmanuel Charles.;Muriel Cornet.;Bertrand Souweine.;Kada Klouche.;Samir Jaber.;Jean-Louis Trouillet.;Fabrice Bruneel.;Laurent Argaud.;Joel Cousson.;Ferhat Meziani.;Didier Gruson.;Adeline Paris.;Michael Darmon.;Maité Garrouste-Orgeas.;Jean-Christophe Navellou.;Arnaud Foucrier.;Bernard Allaouchiche.;Vincent Das.;Jean-Pierre Gangneux.;Stéphane Ruckly.;Daniele Maubon.;Vincent Jullien.;Michel Wolff.; .
来源: JAMA. 2016年316卷15期1555-1564页
Although frequently used in treating intensive care unit (ICU) patients with sepsis, empirical antifungal therapy, initiated for suspected fungal infection, has not been shown to improve outcome.
327. Effect of Conservative vs Conventional Oxygen Therapy on Mortality Among Patients in an Intensive Care Unit: The Oxygen-ICU Randomized Clinical Trial.
作者: Massimo Girardis.;Stefano Busani.;Elisa Damiani.;Abele Donati.;Laura Rinaldi.;Andrea Marudi.;Andrea Morelli.;Massimo Antonelli.;Mervyn Singer.
来源: JAMA. 2016年316卷15期1583-1589页
Despite suggestions of potential harm from unnecessary oxygen therapy, critically ill patients spend substantial periods in a hyperoxemic state. A strategy of controlled arterial oxygenation is thus rational but has not been validated in clinical practice.
328. Effect of Postextubation High-Flow Nasal Cannula vs Noninvasive Ventilation on Reintubation and Postextubation Respiratory Failure in High-Risk Patients: A Randomized Clinical Trial.
作者: Gonzalo Hernández.;Concepción Vaquero.;Laura Colinas.;Rafael Cuena.;Paloma González.;Alfonso Canabal.;Susana Sanchez.;Maria Luisa Rodriguez.;Ana Villasclaras.;Rafael Fernández.
来源: JAMA. 2016年316卷15期1565-1574页
High-flow conditioned oxygen therapy delivered through nasal cannulae and noninvasive mechanical ventilation (NIV) may reduce the need for reintubation. Among the advantages of high-flow oxygen therapy are comfort, availability, lower costs, and additional physiopathological mechanisms.
337. Clinical Practice Guidelines From the AABB: Red Blood Cell Transfusion Thresholds and Storage.
作者: Jeffrey L Carson.;Gordon Guyatt.;Nancy M Heddle.;Brenda J Grossman.;Claudia S Cohn.;Mark K Fung.;Terry Gernsheimer.;John B Holcomb.;Lewis J Kaplan.;Louis M Katz.;Nikki Peterson.;Glenn Ramsey.;Sunil V Rao.;John D Roback.;Aryeh Shander.;Aaron A R Tobian.
来源: JAMA. 2016年316卷19期2025-2035页
More than 100 million units of blood are collected worldwide each year, yet the indication for red blood cell (RBC) transfusion and the optimal length of RBC storage prior to transfusion are uncertain.
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