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312. A case of IgG4-related hepatic inflammatory pseudotumor replaced by an abscess after steroid treatment.
作者: Masayuki Shibata.;Hiroyuki Matsubayashi.;Tsuyoshi Aramaki.;Katsuhiko Uesaka.;Naoyuki Tsutsumi.;Keiko Sasaki.;Hiroyuki Ono.
来源: BMC Gastroenterol. 2016年16卷1期89页
Hepatic inflammatory pseudotumor (IPT) is a rare disease which often mimics a malignant tumor and is therefore often misdiagnosed and surgically resected. Recently, a concept of IgG4-related diseases (IgG4-RD) has been proposed that is becoming widely recognized and includes IgG4-related hepatic IPT. Corticosteroids are widely accepted as the standard treatment.
313. A meta-analysis of long follow-up outcomes of laparoscopic Nissen (total) versus Toupet (270°) fundoplication for gastro-esophageal reflux disease based on randomized controlled trials in adults.
作者: Xing Du.;Zhiwei Hu.;Chao Yan.;Chao Zhang.;Zhonggao Wang.;Jimin Wu.
来源: BMC Gastroenterol. 2016年16卷1期88页
Laparoscopic Nissen fundoplication (LNF) is the most common surgical procedure for the surgical management of gastro-esophageal reflux disease (GERD). Laparoscopic Toupet fundoplication (LTF) has been reported to have a lower prevalence of postoperative complications yet still obtain a similar level of reflux control. We conducted a meta-analysis to confirm the value of LNF and LTF.
315. Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon.
作者: Stephanie N Spohn.;Francesca Bianco.;Rachel B Scott.;Catherine M Keenan.;Alisha A Linton.;Conor H O'Neill.;Elena Bonora.;Michael Dicay.;Brigitte Lavoie.;Rebecca L Wilcox.;Wallace K MacNaughton.;Roberto De Giorgio.;Keith A Sharkey.;Gary M Mawe.
来源: Gastroenterology. 2016年151卷5期933-944.e3页
The 5-hydroxytryptamine receptor 4 (5-HT4R or HTR4) is expressed in the colonic epithelium but little is known about its functions there. We examined whether activation of colonic epithelial 5-HT4R protects colons of mice from inflammation.
317. Efficacy and safety of eflornithine (CPP-1X)/sulindac combination therapy versus each as monotherapy in patients with familial adenomatous polyposis (FAP): design and rationale of a randomized, double-blind, Phase III trial.
作者: Carol A Burke.;Evelien Dekker.;N Jewel Samadder.;Elena Stoffel.;Alfred Cohen.
来源: BMC Gastroenterol. 2016年16卷1期87页
Molecular studies suggest inhibition of colorectal mucosal polyamines (PAs) may be a promising approach to prevent colorectal cancer (CRC). Inhibition of ornithine decarboxylase (ODC) using low-dose eflornithine (DFMO, CPP-1X), combined with maximal PA export using low-dose sulindac, results in greatly reduced levels of normal mucosal PAs. In a clinical trial, this combination (compared with placebo) reduced the 3-year incidence of subsequent high-risk adenomas by >90 %. Familial Adenomatous Polyposis (FAP) is characterized by marked up-regulation of ODC in normal intestinal epithelial and adenoma tissue, and therefore PA reduction might be a potential strategy to control progression of FAP-related intestinal polyposis. CPP FAP-310, a randomized, double-blind, Phase III trial was designed to examine the safety and efficacy of sulindac and DFMO (alone or in combination) for preventing a clinically relevant FAP-related progression event in individuals with FAP.
319. Inflammation-Induced Expression and Secretion of MicroRNA 122 Leads to Reduced Blood Levels of Kidney-Derived Erythropoietin and Anemia.
作者: Mila Rivkin.;Alina Simerzin.;Elina Zorde-Khvalevsky.;Chofit Chai.;Jonathan B Yuval.;Nofar Rosenberg.;Rona Harari-Steinfeld.;Ronen Schneider.;Gail Amir.;Reba Condiotti.;Mathias Heikenwalder.;Achim Weber.;Christoph Schramm.;Henning Wege.;Johannes Kluwe.;Eithan Galun.;Hilla Giladi.
来源: Gastroenterology. 2016年151卷5期999-1010.e3页
Anemia is associated commonly with acute and chronic inflammation, but the mechanisms of their interaction are not clear. We investigated whether microRNA 122 (MIR122), which is generated in the liver and is secreted into the blood, is involved in the development of anemia associated with inflammation.
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