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301. Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1.
作者: Fayez Hadji.;Marie-Chloé Boulanger.;Simon-Pierre Guay.;Nathalie Gaudreault.;Soumiya Amellah.;Guada Mkannez.;Rihab Bouchareb.;Joël Tremblay Marchand.;Mohamed Jalloul Nsaibia.;Sandra Guauque-Olarte.;Philippe Pibarot.;Luigi Bouchard.;Yohan Bossé.;Patrick Mathieu.
来源: Circulation. 2016年134卷23期1848-1862页
Calcific aortic valve disease is characterized by an abnormal mineralization of the aortic valve. Osteogenic activity in the aortic valve is under the control of NOTCH1, which regulates the expression of key pro-osteogenic genes such as RUNX2 and BMP2. Long noncoding RNAs (lncRNAs) may reprogram cells by altering the gene expression pattern.
303. Early Cessation of Adenosine Diphosphate Receptor Inhibitors Among Acute Myocardial Infarction Patients Treated With Percutaneous Coronary Intervention: Insights From the TRANSLATE-ACS Study (Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome).
作者: Emil L Fosbøl.;Christine Ju.;Kevin J Anstrom.;Marjorie E Zettler.;John C Messenger.;Ron Waksman.;Mark B Effron.;Brian A Baker.;David J Cohen.;Eric D Peterson.;Tracy Y Wang.
来源: Circ Cardiovasc Interv. 2016年9卷11期
Guidelines recommend the use of adenosine diphosphate receptor inhibitor (ADPri) therapy for 1 year postacute myocardial infarction; yet, early cessation of therapy occurs frequently in clinical practice.
305. Long-Term Follow-Up After Catheter Ablation of Atrioventricular Nodal Reentrant Tachycardia in Children.
作者: David Backhoff.;Sophia Klehs.;Matthias J Müller.;Heike E Schneider.;Thomas Kriebel.;Thomas Paul.;Ulrich Krause.
来源: Circ Arrhythm Electrophysiol. 2016年9卷11期
Catheter ablation of the slow conducting pathway (SP) is treatment of choice for atrioventricular nodal reentrant tachycardia (AVNRT). Although there are abundant data on AVNRT ablation in adult patients, little is known about the long-term results ≥3 years after AVNRT ablation in pediatric patients.
306. Pulmonary Vein Antral Isolation and Nonpulmonary Vein Trigger Ablation Are Sufficient to Achieve Favorable Long-Term Outcomes Including Transformation to Paroxysmal Arrhythmias in Patients With Persistent and Long-Standing Persistent Atrial Fibrillation.
作者: Jackson J Liang.;Melissa A Elafros.;Daniele Muser.;Rajeev K Pathak.;Pasquale Santangeli.;Erica S Zado.;David S Frankel.;Gregory E Supple.;Robert D Schaller.;Rajat Deo.;Fermin C Garcia.;David Lin.;Mathew D Hutchinson.;Michael P Riley.;David J Callans.;Francis E Marchlinski.;Sanjay Dixit.
来源: Circ Arrhythm Electrophysiol. 2016年9卷11期
Transformation from persistent to paroxysmal atrial fibrillation (AF) after ablation suggests modification of the underlying substrate. We examined the nature of initial arrhythmia recurrence in patients with nonparoxysmal AF undergoing antral pulmonary vein isolation and nonpulmonary vein trigger ablation and correlated recurrence type with long-term ablation efficacy after the last procedure.
307. Readthrough-Promoting Drugs Gentamicin and PTC124 Fail to Rescue Nav1.5 Function of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying Nonsense Mutations in the Sodium Channel Gene SCN5A.
作者: Georgios Kosmidis.;Christiaan C Veerman.;Simona Casini.;Arie O Verkerk.;Simone van de Pas.;Milena Bellin.;Arthur A M Wilde.;Christine L Mummery.;Connie R Bezzina.
来源: Circ Arrhythm Electrophysiol. 2016年9卷11期
Several compounds have been reported to induce translational readthrough of premature stop codons resulting in the production of full-length protein by interfering with ribosomal proofreading. Here we examined the effect of 2 of these compounds, gentamicin and PTC124, in human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes bearing nonsense mutations in the sodium channel gene SCN5A, which are associated with conduction disease and potential lethal arrhythmias.
308. Characteristics of Decremental Accessory Pathways in Children.
作者: Allison C Hill.;Michael J Silka.;Choo Phei Wee.;Yaniv Bar-Cohen.
来源: Circ Arrhythm Electrophysiol. 2016年9卷11期
Although retrograde decremental accessory pathways (DAPs) are thought to typically present as permanent junctional reciprocating tachycardia (permanent junctional reciprocating tachycardia), they may also be diagnosed unexpectedly during electrophysiology study. We aimed to compare the clinical and electrophysiological characteristics of patients with DAPs to an age-matched cohort with nondecremental accessory pathways.
309. Homozygous Familial Hypercholesterolemia in Spain: Prevalence and Phenotype-Genotype Relationship.
作者: Rosa M Sánchez-Hernández.;Fernando Civeira.;Marianne Stef.;Sofía Perez-Calahorra.;Fátima Almagro.;Nuria Plana.;Francisco J Novoa.;Pedro Sáenz-Aranzubía.;Daniel Mosquera.;Cristina Soler.;Francisco J Fuentes.;Yeray Brito-Casillas.;Jose T Real.;Francisco Blanco-Vaca.;Juan F Ascaso.;Miguel Pocovi.
来源: Circ Cardiovasc Genet. 2016年9卷6期504-510页
Homozygous familial hypercholesterolemia (HoFH) is a rare disease characterized by elevated plasma levels of low-density lipoprotein cholesterol (LDL-C) and extremely high risk of premature atherosclerotic cardiovascular disease. HoFH is caused by mutations in several genes, including LDL receptor (LDLR), apolipoprotein B (APOB), proprotein convertase subtilisin/kexin type 9 (PCSK9), and LDL protein receptor adaptor 1 (LDLRAP1). No epidemiological studies have assessed HoFH prevalence or the clinical and molecular characteristics of this condition. Here, we aimed to characterize HoFH in Spain.
310. Cardiovascular Risk Factors Associated With Blood Metabolite Concentrations and Their Alterations During a 4-Year Period in a Population-Based Cohort.
作者: Maria Elena Lacruz.;Alexander Kluttig.;Daniel Tiller.;Daniel Medenwald.;Ina Giegling.;Dan Rujescu.;Cornelia Prehn.;Jerzy Adamski.;Stefan Frantz.;Karin Halina Greiser.;Rebecca Thwing Emeny.;Gabi Kastenmüller.;Johannes Haerting.
来源: Circ Cardiovasc Genet. 2016年9卷6期487-494页
The effects of lifestyle risk factors considered collectively on the human metabolism are to date unknown. We aim to investigate the association of these risk factors with metabolites and their changes during 4 years.
311. Comprehensive Analysis of Established Dyslipidemia-Associated Loci in the Diabetes Prevention Program.
作者: Tibor V Varga.;Alexandra H Winters.;Kathleen A Jablonski.;Edward S Horton.;Prajakta Khare-Ranade.;William C Knowler.;Santica M Marcovina.;Frida Renström.;Karol E Watson.;Ronald Goldberg.;José C Florez.;Toni I Pollin.;Paul W Franks.
来源: Circ Cardiovasc Genet. 2016年9卷6期495-503页
We assessed whether 234 established dyslipidemia-associated loci modify the effects of metformin treatment and lifestyle intervention (versus placebo control) on lipid and lipid subfraction levels in the Diabetes Prevention Program randomized controlled trial.
312. Variations in Abdominal Aortic Aneurysm Care: A Report From the International Consortium of Vascular Registries.
作者: Adam W Beck.;Art Sedrakyan.;Jialin Mao.;Maarit Venermo.;Rumi Faizer.;Sebastian Debus.;Christian-Alexander Behrendt.;Salvatore Scali.;Martin Altreuther.;Marc Schermerhorn.;Barry Beiles.;Zoltan Szeberin.;Nikolaj Eldrup.;Gudmundur Danielsson.;Ian Thomson.;Pius Wigger.;Martin Björck.;Jack L Cronenwett.;Kevin Mani.; .
来源: Circulation. 2016年134卷24期1948-1958页
This project by the ICVR (International Consortium of Vascular Registries), a collaboration of 11 vascular surgical quality registries, was designed to evaluate international variation in the contemporary management of abdominal aortic aneurysm (AAA) with relation to recommended treatment guidelines from the Society for Vascular Surgery and the European Society for Vascular Surgery.
313. MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease.
作者: Dorothee Hartmann.;Jan Fiedler.;Kristina Sonnenschein.;Annette Just.;Angelika Pfanne.;Karina Zimmer.;Janet Remke.;Ariana Foinquinos.;Malte Butzlaff.;Katharina Schimmel.;Lars Maegdefessel.;Denise Hilfiker-Kleiner.;Nico Lachmann.;Andreas Schober.;Natali Froese.;Jörg Heineke.;Johann Bauersachs.;Sandor Batkai.;Thomas Thum.
来源: Circulation. 2016年134卷24期1973-1990页
The transcription factor GATA2 orchestrates the expression of many endothelial-specific genes, illustrating its crucial importance for endothelial cell function. The capacity of this transcription factor in orchestrating endothelial-important microRNAs (miRNAs/miR) is unknown.
314. Health Status Outcomes in Patients With Acute Myocardial Infarction After Rehospitalization.
作者: Supriya Shore.;Kim G Smolderen.;Kevin F Kennedy.;Philip G Jones.;Suzanne V Arnold.;David J Cohen.;Joshua M Stolker.;Zhenxiang Zhao.;Tracy Y Wang.;P Michael Ho.;John A Spertus.
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷6期777-784页
Rehospitalizations after acute myocardial infarction for unplanned coronary revascularization and unstable angina (UA) are common. However, despite the inclusion of these events in composite end points of many clinical trials, their association with health status has not been studied.
315. Guideline-Appropriate Care and In-Hospital Outcomes in Patients With Heart Failure in Teaching and Nonteaching Hospitals: Findings From Get With The Guidelines-Heart Failure.
作者: Dhavalkumar B Patel.;Rachit M Shah.;Deepak L Bhatt.;Li Liang.;Phillip J Schulte.;Adam D DeVore.;Adrian F Hernandez.;Paul A Heidenreich.;Clyde W Yancy.;Gregg C Fonarow.
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷6期757-766页
Despite increasing awareness regarding evidence-based guidelines, considerable gaps exist for heart failure (HF) quality of care at teaching hospitals (TH) and nonteaching hospitals (NTH). We analyzed data from Get With The Guidelines (GWTG)-HF to compare the rates and trends of guideline-recommended care at TH and NTH for patients with HF.
316. Sucrose Nonfermenting-Related Kinase Enzyme-Mediated Rho-Associated Kinase Signaling is Responsible for Cardiac Function.
作者: Stephanie M Cossette.;Vijesh J Bhute.;Xiaoping Bao.;Leanne M Harmann.;Mark A Horswill.;Indranil Sinha.;Adam Gastonguay.;Shabnam Pooya.;Michelle Bordas.;Suresh N Kumar.;Shama P Mirza.;Sean P Palecek.;Jennifer L Strande.;Ramani Ramchandran.
来源: Circ Cardiovasc Genet. 2016年9卷6期474-486页
Cardiac metabolism is critical for the functioning of the heart, and disturbance in this homeostasis is likely to influence cardiac disorders or cardiomyopathy. Our laboratory has previously shown that SNRK (sucrose nonfermenting related kinase) enzyme, which belongs to the AMPK (adenosine monophosphate-activated kinase) family, was essential for cardiac metabolism in mammals. Snrk global homozygous knockout (KO) mice die at postnatal day 0, and conditional deletion of Snrk in cardiomyocytes (Snrk cmcKO) leads to cardiac failure and death by 8 to 10 months.
317. Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile Using Historical Data.
作者: Jonathan D Mosley.;Sara L van Driest.;Quinn S Wells.;Christian M Shaffer.;Todd L Edwards.;Lisa Bastarache.;Catherine A McCarty.;Will Thompson.;Christopher G Chute.;Gail P Jarvik.;David R Crosslin.;Eric B Larson.;Iftikhar J Kullo.;Jennifer A Pacheco.;Peggy L Peissig.;Murray H Brilliant.;James G Linneman.;Josh C Denny.;Dan M Roden.
来源: Circ Cardiovasc Genet. 2016年9卷6期521-530页
Continued reductions in morbidity and mortality attributable to ischemic heart disease (IHD) require an understanding of the changing epidemiology of this disease. We hypothesized that we could use genetic correlations, which quantify the shared genetic architectures of phenotype pairs and extant risk factors from a historical prospective study to define the risk profile of a contemporary IHD phenotype.
318. Clinical Utility of Multimarker Genetic Risk Scores for Prediction of Incident Coronary Heart Disease: A Cohort Study Among Over 51 000 Individuals of European Ancestry.
作者: Carlos Iribarren.;Meng Lu.;Eric Jorgenson.;Manuel Martínez.;Carla Lluis-Ganella.;Isaac Subirana.;Eduardo Salas.;Roberto Elosua.
来源: Circ Cardiovasc Genet. 2016年9卷6期531-540页
We evaluated whether including multilocus genetic risk scores (GRSs) into the Framingham Risk Equation improves the predictive capacity, discrimination, and reclassification of asymptomatic individuals with respect to coronary heart disease (CHD) risk.
319. Variation in Hospital Use and Outcomes Associated With Pulmonary Artery Catheterization in Heart Failure in the United States.
作者: Rohan Khera.;Ambarish Pandey.;Nilay Kumar.;Rajeev Singh.;Shah Bano.;Harsh Golwala.;Dharam J Kumbhani.;Saket Girotra.;Gregg C Fonarow.
来源: Circ Heart Fail. 2016年9卷11期
There has been an increase in the use of pulmonary artery (PA) catheters in heart failure (HF) in the United States in recent years. However, patterns of hospital use and trends in patient outcomes are not known.
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