We report 2 cases of successful use of fecal microbiota therapy (fecal transplant) for recurrent Clostridium difficile infection in HIV-infected individuals. Both patients had many recurrences despite antibiotic therapy and improved after receiving fecal microbiota from healthy donors. Recurrent Clostridium difficile infection (CDI) is a common and difficult to manage problem. The risk of recurrence after a first episode is estimated to be around 20–30%, and is even higher after second or later recurrences[1]. A disrupted fecal microbiota from previous use of antibiotics plays a major role in recurrent CDI[1]. Because of the high rate of recurrence, many different treatment alternatives have been proposed[1]. In recent years several cases of successful use of fecal microbiota therapy (FMT) in the treatment of recurrent CDI have been published, with a reported success rate over 90% [1]. Here we present what to our knowledge is the first report of FMT in HIV-infected individuals.