186. Hospital-Diagnosed Pertussis Infection in Children and Long-term Risk of Epilepsy.
作者: Morten Olsen.;Sandra K Thygesen.;John R Østergaard.;Henrik Nielsen.;Victor W Henderson.;Vera Ehrenstein.;Mette Nørgaard.;Henrik Toft Sørensen.
来源: JAMA. 2015年314卷17期1844-9页
Pertussis is associated with encephalopathy and seizures in infants. However, the risk of childhood epilepsy following pertussis is unknown.
187. Endovascular Thrombectomy for Acute Ischemic Stroke: A Meta-analysis.
作者: Jetan H Badhiwala.;Farshad Nassiri.;Waleed Alhazzani.;Magdy H Selim.;Forough Farrokhyar.;Julian Spears.;Abhaya V Kulkarni.;Sheila Singh.;Abdulrahman Alqahtani.;Bram Rochwerg.;Mohammad Alshahrani.;Naresh K Murty.;Adel Alhazzani.;Blake Yarascavitch.;Kesava Reddy.;Osama O Zaidat.;Saleh A Almenawer.
来源: JAMA. 2015年314卷17期1832-43页
Endovascular intervention for acute ischemic stroke improves revascularization. But trials examining endovascular therapy yielded variable functional outcomes, and the effect of endovascular intervention among subgroups needs better definition.
188. Trends in Prescription Drug Use Among Adults in the United States From 1999-2012.
作者: Elizabeth D Kantor.;Colin D Rehm.;Jennifer S Haas.;Andrew T Chan.;Edward L Giovannucci.
来源: JAMA. 2015年314卷17期1818-31页
It is important to document patterns of prescription drug use to inform both clinical practice and research.
189. Efavirenz-Based Antiretroviral Therapy Among Nevirapine-Exposed HIV-Infected Children in South Africa: A Randomized Clinical Trial.
作者: Ashraf Coovadia.;Elaine J Abrams.;Renate Strehlau.;Stephanie Shiau.;Francoise Pinillos.;Leigh Martens.;Faeezah Patel.;Gillian Hunt.;Wei-Yann Tsai.;Louise Kuhn.
来源: JAMA. 2015年314卷17期1808-17页
Advantages of using efavirenz as part of treatment for children infected with human immunodeficiency virus (HIV) include once-daily dosing, simplification of co-treatment for tuberculosis, preservation of ritonavir-boosted lopinavir for second-line treatment, and harmonization of adult and pediatric treatment regimens. However, there have been concerns about possible reduced viral efficacy of efavirenz in children exposed to nevirapine for prevention of mother-to-child transmission.
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