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3. Transcatheter aortic valve implantation with the Trilogy valve for symptomatic native aortic regurgitation (ALIGN-AR): a pivotal, multicentre, single-arm, investigational device exemption study.
作者: Raj R Makkar.;Vinod H Thourani.;Torsten P Vahl.;Pradeep K Yadav.;James M McCabe.;Isaac George.;Lowell Satler.;Stan Chetcuti.;David V Daniels.;Thomas Waggoner.;Brian Whisenant.;Mark Russo.;Matthew Summers.;Santiago Garcia.;Tiberio Frisoli.;Ravi K Ramana.;Curtiss Stinis.;Harsh Golwala.;Firas Zahr.;Adam Greenbaum.;Joshua Rovin.;Carlos Sanchez.;Molly Szerlip.;George Michael Deeb.;Nicholas Amoroso.;Dhairya Patel.;Martin Fahy.;Lauren S Ranard.;Aakriti Gupta.;Tarun Chakravarty.;Sabah Skaf.;Michael Chuang.;Susheel K Kodali.;Hans R Figulla.;Hendrik Treede.;Stephan Baldus.;Duane S Pinto.;Martin B Leon.; .
来源: Lancet. 2025年
Transcatheter devices designed for calcific aortic stenosis are not optimised for use in native aortic regurgitation, and data on aortic regurgitation-dedicated platforms are limited. The extended ALIGN-AR pivotal experience with a prospectively enrolled continued-access cohort and longer follow-up aimed to characterise the safety, valve function, and clinical outcomes of transcatheter aortic valve intervention (TAVI) with a dedicated device in aortic regurgitation.
6. Safety and immunogenicity of a Nipah virus vaccine (HeV-sG-V) in adults: a single-centre, randomised, observer-blind, placebo-controlled, phase 1 study.
作者: Robert W Frenck.;Abdi Naficy.;Jodi Feser.;Michelle P Dickey.;Victor H Leyva-Grado.;Michael A Egan.;Tracy Chen.;John H Eldridge.;Susan Sciotto-Brown.;Luz Hermida.;Dominique Promeneur.;Amara Luckay.;Herbert Medina.;Glorie-Grace A Lazaro.;Nairuti R Patel.;Tahira Naqvi.;Christopher C Broder.;Antony S Dimitrov.;Chris Gast.;Laina D Mercer.;Mike Raine.;Indah Andi-Lolo.;Bruce L Innis.;John J Aponte.;Stefan Hamm.;Niraj Rathi.
来源: Lancet. 2025年
First discovered in 1999 in Malaysia, Nipah virus (NiV) causes yearly outbreaks throughout south and southeast Asia with associated mortality rates of 40-75%. Due to the structural and sequence similarities between the NiV and Hendra virus (HeV) attachment G glycoproteins, and the extensive extant evidence of the ability of a recombinant soluble glycoprotein G (HeV-sG) to provide heterologous cross-protective immunity when used as vaccine (HeV-sG-V), this study aimed to evaluate HeV-sG-V for safety, tolerability, and immunogenicity against NiV.
7. A clinical practice guide to transform care and save newborn lives with kangaroo mother care.
作者: Shuchita Gupta.;Gary L Darmstadt.;Betty Kirkwood.;Per Ashorn.;Ebunoluwa Adejuyigbe.;Nils Bergman.;Nathalie Charpak.;Harish Chellani.;Nicholas Embleton.;Elizabeth Franklin.;Silke Mader.;Sarmila Mazumder.
来源: Lancet. 2025年 10. The Lancet MedZero: carbon analytics for health care, by health care, at scale.
作者: Nick Watts.;Thomas Andrew.;Jessamy Bagenal.;Matthew J Eckelman.;Jacob Fry.;Agnes Henson.;Richard Horton.;Wanrudee Isaranuwatchai.;Slava Jankin.;Sarin Kc.;Jonathan T E Lee.;Scott McAlister.;Forbes McGain.;Keisuke Nansai.;Catherine O'Shea.;Lydia Tang.;Michelle Tan Bee Hua.;Chantelle Rizan.
来源: Lancet. 2025年 11. A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial.
作者: Alexander Zarbock.;Marlies Ostermann.;Lui Forni.;Christian Bode.;Lennart Wild.;Christian Putensen.;Diego Parise Roux.;Elena Elías Martín.;Christian Arndt.;Tim Rahmel.;Silvia de Rosa.;Céline Monard.;Antoine G Schneider.;Adam Glass.;Mona Jung-König.;Stefano Romagnoli.;James Gossage.;Nuttha Lumlertgul.;Jan Gerrit Haaker.;Javier Ripollés-Melchor.;Savino Spadaro.;Antonio Siniscalchi.;Emmanuel Futier.;Lucie Aupetitgendre.;Irene Romero Bhathal.;Raquel García Álvarez.;Alice Bernard.;Peter Rosenberger.;Carola Wempe.;Mahan Sadjadi.;Melanie Meersch.;Karen Fischhuber.;Rinaldo Bellomo.;John A Kellum.;Thilo von Groote.; .
来源: Lancet. 2025年
Acute kidney injury (AKI) is a common and important complication of major surgery, yet recommended preventive care is rarely administered. We used urinary biomarkers to identify patients at high risk of AKI and implemented a preventive care strategy to reduce AKI within 72 h after major surgery.
12. Hyperemesis gravidarum.
Hyperemesis gravidarum describes nausea and vomiting in pregnancy severe enough to cause weight loss, dehydration, electrolyte imbalance, and nutritional deficiencies. The condition can render women so physically and mentally unwell that they are at increased risk of terminating a wanted pregnancy and experiencing suicidal ideation. Concerns regarding prescribing in pregnancy and inaccurate assumptions that the condition is self-limiting result in women being dismissed and having difficulty accessing appropriate care. Over the past decade, a wealth of literature has been published that gives new insights into the causes of hyperemesis gravidarum, the safety of antiemetic therapy, and short-term and long-term consequences for women with the condition and their children. This Review summarises the findings of this literature with the aim of informing decisions about the care of these women and future research priorities.
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