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1. Cost-Effectiveness of Aortic Valve Replacement in Low- and Intermediate-Risk Chinese Patients With Severe Aortic Stenosis.
作者: Jin Peng.;Xinglong Zheng.;Minghuan Jiang.;Xuelin Yao.;Yue Ma.;Mao Fu.;Tao Ma.;Xiaolong Shang.;Yang Yan.;Vinod H Thourani.;Yu Fang.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷4期e010858页
Transcatheter aortic valve replacement (TAVR) remains debated as an alternative to surgical aortic valve replacement (SAVR). We aimed to evaluate the cost-effectiveness of aortic valve replacement strategies in low- and intermediate-risk patients with severe aortic stenosis in China.
2. Early Versus Delayed Invasive Management of Female Patients With Non-ST-Elevation Acute Coronary Syndrome: An Individual Patient Data Meta-Analysis.
作者: Gregory B Mills.;Christos P Kotanidis.;Shamir Mehta.;Denise Tiong.;Erik A Badings.;Thomas Engstrøm.;Arnoud W J van 't Hof.;Dan Høfsten.;Lene Holmvang.;Alexander Jobs.;Lars Køber.;Dejan Milasinovic.;Aleksandra Milosevic.;Goran Stankovic.;Holger Thiele.;Roxana Mehran.;Vijay Kunadian.
来源: Circ Cardiovasc Interv. 2025年18卷3期e014763页
Female patients are at greater risk of adverse events following non-ST-elevation acute coronary syndrome but less frequently receive guideline-recommended coronary angiography and revascularization. Routine invasive management benefits high-risk patients, but evidence informing the optimal timing of angiography specifically in female patients is lacking.
3. Natural History, Phenotype Spectrum, and Clinical Outcomes of Desmin (DES)-Associated Cardiomyopathy.
作者: Babken Asatryan.;Marina Rieder.;Brittney Murray.;Steven A Muller.;Crystal Tichnell.;Alessio Gasperetti.;Richard T Carrick.;Emily Joseph.;Doris G Leung.;Anneline S J M Te Riele.;Stefan L Zimmerman.;Hugh Calkins.;Cynthia A James.;Andreas S Barth.
来源: Circ Genom Precis Med. 2025年18卷2期e004878页
Pathogenic/likely pathogenic (LP) desmin (DES) variants cause heterogeneous cardiomyopathy and skeletal myopathy phenotypes. Limited data suggest a high incidence of major adverse cardiac events (MACEs), including cardiac conduction disease, sustained ventricular arrhythmias (VA), and heart failure (HF) events (HF hospitalization, left ventricular assist device/cardiac transplant, HF-related death) in patients with pathogenic/LP DES variants. However, pleiotropic presentation and small cohort sizes have limited clinical phenotype and outcome characterization. We aimed to describe the natural history, phenotype spectrum, familial penetrance and outcomes in patients with pathogenic/LP DES variants through a systematic review and individual patient data meta-analysis using published reports.
4. Impact of Diagnosis to Ablation Time on Recurrence of Atrial Fibrillation and Clinical Outcomes After Catheter Ablation: A Systematic Review and Meta-Analysis With Reconstructed Time-to-Event Data.
作者: Ahmed Mazen Amin.;Hossam Elbenawi.;Ubaid Khan.;Omar Almaadawy.;Mustafa Turkmani.;Wael Abdelmottaleb.;Mohammed Essa.;Mohamed Abuelazm.;Basel Abdelazeem.;Zain Ul Abideen Asad.;Abhishek Deshmukh.;Mark S Link.;Christopher V DeSimone.
来源: Circ Arrhythm Electrophysiol. 2025年18卷2期e013261页
Current clinical guidelines emphasize the significance of rhythm control with catheter ablation but lack guidance on the timing of atrial fibrillation (AF) ablation relative to the diagnosis time. We aim to investigate the latest evidence on the impact of diagnosis to ablation time (DAT) on clinical outcomes after AF ablation.
5. Systematic Review, Meta-Analysis, and Population Study to Determine the Biologic Sex Ratio in Dilated Cardiomyopathy.
作者: Natalie Bergan.;Ishika Prachee.;Lara Curran.;Kathryn A McGurk.;Chang Lu.;Antonio de Marvao.;Wenjia Bai.;Brian P Halliday.;John Gregson.;Declan P O'Regan.;James S Ware.;Upasana Tayal.
来源: Circulation. 2025年151卷7期442-459页
Dilated cardiomyopathy (DCM) appears to be diagnosed twice as often in male than in female patients. This could be attributed to underdiagnosis in female patients or sex differences in susceptibility. Up to 30% of cases have an autosomal dominant monogenic cause, where equal sex prevalence would be expected. The aim of this systematic review, meta-analysis, and population study was to assess the sex ratio in patients with DCM, stratified by genetic status, and evaluate whether this is influenced by diagnostic bias.
6. Independence of Lipoprotein(a) and Low-Density Lipoprotein Cholesterol-Mediated Cardiovascular Risk: A Participant-Level Meta-Analysis.
作者: Harpreet S Bhatia.;Simon Wandel.;Peter Willeit.;Anastasia Lesogor.;Keith Bailey.;Paul M Ridker.;Paul Nestel.;John Simes.;Andrew Tonkin.;Gregory G Schwartz.;Helen Colhoun.;Christoph Wanner.;Sotirios Tsimikas.
来源: Circulation. 2025年151卷4期312-321页
Low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) (Lp[a]) levels are independently associated with atherosclerotic cardiovascular disease (ASCVD). However, the relationship between Lp(a) level, LDL-C level, and ASCVD risk at different thresholds is not well defined.
7. Effects of Catheter-Based Renal Denervation in Hypertension: A Systematic Review and Meta-Analysis.
作者: Davor Vukadinović.;Lucas Lauder.;David E Kandzari.;Deepak L Bhatt.;Ajay J Kirtane.;Elazer R Edelman.;Roland E Schmieder.;Michel Azizi.;Michael Böhm.;Felix Mahfoud.
来源: Circulation. 2024年150卷20期1599-1611页
Several sham-controlled trials have investigated the efficacy and safety of catheter-based renal denervation (RDN) with mixed outcomes. We aimed to perform a comprehensive meta-analysis of all randomized, sham-controlled trials investigating RDN with first- and second-generation devices in hypertension.
8. Stroke Prevention With Prophylactic Left Atrial Appendage Occlusion in Cardiac Surgery Patients Without Atrial Fibrillation: A Meta-Analysis of Randomized and Propensity-Score Studies.
作者: Massimo Baudo.;Serge Sicouri.;Yoshiyuki Yamashita.;Mikiko Senzai.;Patrick M McCarthy.;Marc W Gerdisch.;Richard P Whitlock.;Basel Ramlawi.
来源: Circ Cardiovasc Interv. 2024年17卷10期e014296页
The role of left atrial appendage occlusion (LAAO) in patients without previous atrial fibrillation (AF) is not established. This meta-analysis was conducted on patients with normal sinus rhythm who underwent cardiac surgery, with and without concomitant LAAO, to evaluate its effect on the incidence of cerebrovascular accidents (CVAs).
9. Complete Versus Culprit-Only Revascularization in Older Patients With ST-Segment-Elevation Myocardial Infarction: An Individual Patient Meta-Analysis.
作者: Gianluca Campo.;Felix Böhm.;Thomas Engstrøm.;Pieter C Smits.;Islam Y Elgendy.;Gerry P McCann.;David A Wood.;Matteo Serenelli.;Stefan James.;Dan Eik Høfsten.;Bianca M Boxm-de Klerk.;Adrian Banning.;John A Cairns.;Rita Pavasini.;Goran Stankovic.;Petr Kala.;Henning Kelbæk.;Emanuele Barbato.;Ilija Srdanovic.;Mohamed Hamza.;Amerjeet S Banning.;Simone Biscaglia.;Shamir Mehta.
来源: Circulation. 2024年150卷19期1508-1516页
Complete revascularization is the standard treatment for patients with ST-segment-elevation myocardial infarction and multivessel disease. The FIRE trial (Functional Assessment in Elderly Myocardial Infarction Patients With Multivessel Disease) confirmed the benefit of complete revascularization in a population of older patients, but the follow-up is limited to 1 year. Therefore, the long-term benefit (>1 year) of this strategy in older patients is debated. To address this, an individual patient data meta-analysis was conducted in patients with ST-segment-elevation myocardial infarction ≥75 years of age enrolled in randomized clinical trials investigating complete versus culprit-only revascularization strategies.
10. Cardiovascular, Kidney, and Safety Outcomes With GLP-1 Receptor Agonists Alone and in Combination With SGLT2 Inhibitors in Type 2 Diabetes: A Systematic Review and Meta-Analysis.
作者: Brendon L Neuen.;Robert A Fletcher.;Lauren Heath.;Adam Perkovic.;Muthiah Vaduganathan.;Sunil V Badve.;Katherine R Tuttle.;Richard Pratley.;Hertzel C Gerstein.;Vlado Perkovic.;Hiddo J L Heerspink.
来源: Circulation. 2024年150卷22期1781-1790页
GLP-1 (glucagon-like peptide-1) receptor agonists and SGLT2 (sodium-glucose cotransporter 2) inhibitors both improve cardiovascular and kidney outcomes in people with type 2 diabetes. We conducted a systematic review and meta-analysis to assess the effects of GLP-1 receptor agonists on clinical outcomes with and without SGLT2 inhibitors.
11. Procedural Outcomes With Femoral, Radial, Distal Radial, and Ulnar Access for Coronary Angiography: A Network Meta-Analysis.
作者: M Haisum Maqsood.;Celina M Yong.;Sunil V Rao.;Mauricio G Cohen.;Samir Pancholy.;Sripal Bangalore.
来源: Circ Cardiovasc Interv. 2024年17卷9期e014186页
Radial artery access for coronary angiography or percutaneous coronary intervention (PCI) reduces the risk of death, bleeding, and vascular complications and is preferred over femoral artery access, leading to a class 1 indication by clinical practice guidelines. However, alternate upper extremity access such as distal radial and ulnar access are not mentioned in the guidelines despite randomized trials. We aimed to evaluate procedural outcomes with femoral, radial, distal radial, and ulnar access sites in patients undergoing coronary angiography or PCI.
12. Role of Health Care Professionals in the Success of Blood Pressure Control Interventions in Patients With Hypertension: A Meta-Analysis.
作者: Katherine T Mills.;Samantha S O'Connell.;Meng Pan.;Katherine M Obst.;Hua He.;Jiang He.
来源: Circ Cardiovasc Qual Outcomes. 2024年17卷8期e010396页
Globally, only 13.8% of patients with hypertension have their blood pressure (BP) controlled. Trials testing interventions to overcome barriers to BP control have produced mixed results. Type of health care professional delivering the intervention may play an important role in intervention success. The goal of this meta-analysis is to determine which health care professionals are most effective at delivering BP reduction interventions.
13. Culprit-Only Revascularization, Single-Setting Complete Revascularization, and Staged Complete Revascularization in Acute Myocardial Infarction: Insights From a Mixed Treatment Comparison Meta-Analysis of Randomized Trials.
作者: Muhammad Haisum Maqsood.;Jacqueline E Tamis-Holland.;Sunil V Rao.;Gregg W Stone.;Sripal Bangalore.
来源: Circ Cardiovasc Interv. 2024年17卷7期e013737页
Complete revascularization improves cardiovascular outcomes compared with culprit-only revascularization in patients with acute myocardial infarction ([MI]; ST-segment-elevation MI or non-ST-segment-elevation MI) and multivessel coronary artery disease. However, the timing of complete revascularization (single-setting versus staged revascularization) is uncertain. The aim was to compare the outcomes of single-setting complete, staged complete, and culprit vessel-only revascularization in patients with acute MI and multivessel disease.
14. Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias.
作者: Lu-Chen Weng.;Shaan Khurshid.;Amelia Weber Hall.;Victor Nauffal.;Valerie N Morrill.;Yan V Sun.;Joel T Rämö.;Dominik Beer.;Simon Lee.;Girish Nadkarni.;Renee Johnson.;Laura Andreasen.;Anne Clayton.;Clive R Pullinger.;Zachary T Yoneda.;Daniel J Friedman.;Matthew C Hyman.;Renae L Judy.;Allan C Skanes.;Kate M Orland.;Paloma Jordà.;Timothy M Treu.;Matthew T Oetjens.;Rajesh Subbiah.;Jacob P Hartmann.;Heidi T May.;John P Kane.;Tariq Z Issa.;Navid A Nafissi.;Peter Leong-Sit.;Marie-Pierre Dubé.;Carolina Roselli.;Seung Hoan Choi.; .;Jean-Claude Tardif.;Habib R Khan.;Stacey Knight.;Jesper H Svendsen.;Bruce Walker.;Richard Karlsson Linnér.;J Michael Gaziano.;Rafik Tadros.;Diane Fatkin.;Daniel J Rader.;Svati H Shah.;Dan M Roden.;Gregory M Marcus.;Ruth J F Loos.;Scott M Damrauer.;Christopher M Haggerty.;Kelly Cho.;Aarno Palotie.;Morten S Olesen.;Lee L Eckhardt.;Jason D Roberts.;Michael J Cutler.;M Benjamin Shoemaker.;Peter W F Wilson.;Patrick T Ellinor.;Steven A Lubitz.
来源: Circ Genom Precis Med. 2024年17卷3期e004320页
Substantial data support a heritable basis for supraventricular tachycardias, but the genetic determinants and molecular mechanisms of these arrhythmias are poorly understood. We sought to identify genetic loci associated with atrioventricular nodal reentrant tachycardia (AVNRT) and atrioventricular accessory pathways or atrioventricular reciprocating tachycardia (AVAPs/AVRT).
15. Risks of Restrictive Versus Liberal Red Blood Cell Transfusion Strategies in Patients With Cardiovascular Disease: An Updated Meta-Analysis.
作者: Willard N Applefeld.;Verity J Ford.;Irene Cortes-Puch.;Jeffrey Wang.;Junfeng Sun.;Tracy C Shields.;Robert L Danner.;Peter Q Eichacker.;Michael A Solomon.;Harvey G Klein.;Charles Natanson.
来源: Circ Cardiovasc Qual Outcomes. 2024年17卷6期e010957页 16. Sodium-Glucose Cotransporter-2 Inhibitors and Major Adverse Cardiovascular Outcomes: A SMART-C Collaborative Meta-Analysis.
作者: Siddharth M Patel.;Yu Mi Kang.;KyungAh Im.;Brendon L Neuen.;Stefan D Anker.;Deepak L Bhatt.;Javed Butler.;David Z I Cherney.;Brian L Claggett.;Robert A Fletcher.;William G Herrington.;Silvio E Inzucchi.;Meg J Jardine.;Kenneth W Mahaffey.;Darren K McGuire.;John J V McMurray.;Bruce Neal.;Milton Packer.;Vlado Perkovic.;Scott D Solomon.;Natalie Staplin.;Muthiah Vaduganathan.;Christoph Wanner.;David C Wheeler.;Faiez Zannad.;Yujie Zhao.;Hiddo J L Heerspink.;Marc S Sabatine.;Stephen D Wiviott.
来源: Circulation. 2024年149卷23期1789-1801页
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) consistently improve heart failure and kidney-related outcomes; however, effects on major adverse cardiovascular events (MACE) across different patient populations are less clear.
17. Incremental Value of a Metabolic Risk Score for Heart Failure Mortality: A Population-Based Study.
作者: Jungnam Joo.;Joseph J Shearer.;Anna Wolska.;Alan T Remaley.;James D Otvos.;Margery A Connelly.;Maureen Sampson.;Suzette J Bielinski.;Nicholas B Larson.;Hoyoung Park.;Katherine M Conners.;Sarah Turecamo.;Véronique L Roger.
来源: Circ Genom Precis Med. 2024年17卷2期e004312页
Heart failure is heterogeneous syndrome with persistently high mortality. Nuclear magnetic resonance spectroscopy enables high-throughput metabolomics, suitable for precision phenotyping. We aimed to use targeted metabolomics to derive a metabolic risk score (MRS) that improved mortality risk stratification in heart failure.
19. Meta-Analysis of Normal Reference Values for Right and Left Ventricular Quantification by Cardiovascular Magnetic Resonance.
作者: Yang Zhan.;Matthias G Friedrich.;Nandini Dendukuri.;Yang Lu.;Michael Chetrit.;Ian Schiller.;Lawrence Joseph.;Jaime L Shaw.;Michael L Chuang.;Johannes H Riffel.;Warren J Manning.;Jonathan Afilalo.
来源: Circ Cardiovasc Imaging. 2024年17卷2期e016090页
Cardiovascular magnetic resonance (CMR) reference values are relied upon to accurately diagnose left ventricular (LV) and right ventricular (RV) pathologies. To date, reference values have been derived from modest sample sizes with limited patient diversity and attention to 1 but not both commonly used tracing techniques for papillary muscles and trabeculations. We sought to overcome these limitations by meta-analyzing normal reference values for CMR parameters stemming from multiple countries, vendors, analysts, and patient populations.
20. Coronary Angiography, Intravascular Ultrasound, and Optical Coherence Tomography for Guiding of Percutaneous Coronary Intervention: A Systematic Review and Network Meta-Analysis.
作者: Daniele Giacoppo.;Claudio Laudani.;Giovanni Occhipinti.;Marco Spagnolo.;Antonio Greco.;Carla Rochira.;Federica Agnello.;Davide Landolina.;Maria Sara Mauro.;Simone Finocchiaro.;Placido Maria Mazzone.;Nicola Ammirabile.;Antonino Imbesi.;Carmelo Raffo.;Sergio Buccheri.;Davide Capodanno.
来源: Circulation. 2024年149卷14期1065-1086页
Results from multiple randomized clinical trials comparing outcomes after intravascular ultrasound (IVUS)- and optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) with invasive coronary angiography (ICA)-guided PCI as well as a pivotal trial comparing the 2 intravascular imaging (IVI) techniques have provided mixed results.
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