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1. Incidence, Timing and Clinical Significance of Immune-Mediated Myocardial Injury and Myocarditis After Gene Replacement Therapy: A Systematic Review and Meta-Analysis.
作者: Niccolò Maurizi.;Enrico Ammirati.;Elizabeth Silver.;Kimberly Hong.;Quan Bui.;Alessia Argirò.;Iacopo Olivotto.;Eric D Adler.
来源: Circ Heart Fail. 2026年19卷5期e013771页
Although adeno-associated virus (AAV) gene-replacement therapy is a potentially transformative therapy for severe genetic diseases, its cardiac immunotoxicity may challenge broad clinical use.
2. Post-Catheter Ablation Long-Term Antithrombotic Strategies in Atrial Fibrillation: A Network Meta-Analysis of Randomized Controlled Trials.
作者: Juan F Rodriguez-Riascos.;Dravid Navale.;Aakash Somappa.;Ricardo J Estrada-Mendizabal.;Luis R Scott.;Win-Kuang Shen.;Komandoor Srivathsan.
来源: Circ Arrhythm Electrophysiol. 2026年19卷4期e014692页
Catheter ablation for atrial fibrillation is a widely used rhythm-control strategy, yet its role in reducing thromboembolic risk and enabling oral anticoagulation (OAC) discontinuation remains uncertain. This meta-analysis aims to comprehensively synthesize and evaluate randomized controlled trial evidence supporting long-term antithrombotic strategies in patients with atrial fibrillation undergoing catheter ablation.
3. Prognostic Factors for Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke: A Systematic Review and Meta-Analysis.
作者: Faizan Khan.;Vignan Yogendrakumar.;Ronda Lun.;Caterina E Marx.;Bram Rochwerg.;Alexandre Tran.;Shannon M Fernando.;Aravind Ganesh.;Philip A Barber.;Joachim Ögren.;Angel Ois.;Eva Giralt-Steinhauer.;Andrej Netland Khanevski.;Xinyi Leng.;Xuan Tian.;Thomas W Leung.;Esmee Verburgt.;Jamie Verhoeven.;Frank-Erik de Leeuw.;Fredrik Ildstad.;Simon Fandler-Höfler.;Karoliina Aarnio.;Bettina von Sarnowski.;Diane L Lorenzetti.;Shelagh B Coutts.;Pierre Amarenco.;Graeme J Hankey.;Michael D Hill.
来源: Circulation. 2026年153卷17期1281-1295页
Patients with a transient ischemic attack (TIA) or minor stroke have an increased risk of subsequent stroke that persists for at least 10 years. We aimed to identify prognostic factors associated with long-term risk of stroke in this patient group and estimate their population attributable fraction (PAF).
4. Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve.
作者: Sébastien Thériault.;Jacob A Holdcraft.;Dinara Sharipova.;Adèle Faucherre.;Radoslaw M Debiec.;Gina M Peloso.;Baravan Al-Kassou.;Sary Aranki.;Elena Ashikhmina Swan.;Andrea Ballotta.;Michele Bellino.;Hanna M Björck.;Anne Sophie Boureau.;Peter S Braund.;François Corriveau.;François Dagenais.;Lasse Folkersen.;Amalia Forte.;Michael D Francke.;Alessandro Frigiola.;Svetlana Gorbatov.;Dongchuan Guo.;Karam M Habchi.;Mahyar Heydarpour.;Eric M Isselbacher.;Chris Jopling.;Fabien Laporte.;Solena Le Scouarnec.;Zhonglin Li.;Peter Lichtner.;Carlo Maj.;Hasanga D Manikpurage.;Christopher P Nelson.;Thy B Nguyen.;Russell A Norris.;Chin Siang Ong.;Philippe Pibarot.;Tanmoy Roychowdhury.;Berardo Sarubbi.;Floriane Simonet.;Thoralf Sundt.;Ida Surakka.;Idit Tessler.;Cristen J Willer.;Susanne Wittmann.;Bo Yang.;Igor Berezovets.;Stefanie A Doppler.;Martina Dreßen.;Katharina Knoll.;Thomas Puehler.;Heribert Schunkert.;Jean-François Avierinos.;Malenka M Bissell.;Aidan P Bolger.;Yohan Bossé.;Eduardo Bossone.;María Brion.;Rodolfo Citro.;Carlo de Vincentiis.;G Michael Deeb.;Alessandro Della Corte.;Christian Dina.;Ronen Durst.;Stephan Ensminger.;Per Eriksson.;Arturo Evangelista.;Anders Franco-Cereceda.;Dan Gilon.;Betti Giusti.;Simon L Hetherington.;Gordon S Huggins.;Markus Krane.;Thierry Le Tourneau.;Giuseppe Limongelli.;Patrick Mathieu.;David Messika-Zeitoun.;Hector I Michelena.;Dianna Milewicz.;Jochen D Muehlschlegel.;David R Murdock.;Georg Nickenig.;Stefano Nistri.;Markus M Nöthen.;Francesca Pluchinotta.;Siddharth K Prakash.;Nilesh J Samani.;Jean-Jacques Schott.;Tom R Webb.;Stéphane Zaffran.;Salim Abdelilah-Seyfried.;Kim Eagle.;Johannes Schumacher.;Teresa Trenkwalder.;Simon C Body.
来源: Circulation. 2026年153卷14期1060-1076页
Bicuspid aortic valve (BAV) is a frequent congenital heart defect with a high heritability. Despite this, only a limited number of genes have been associated with the disease, and the molecular mechanisms remain unexplained in most cases. This study aimed to further understand the genetic architecture of BAV.
5. Systemic Embolic Events in Atrial Fibrillation: An Individual Patient Data Meta-analysis of 71 683 Participants Randomized to NOAC Versus Warfarin.
作者: Samer Al Said.;Eugene Braunwald.;Michael G Palazzolo.;Giorgio E M Melloni.;Bram J Geller.;Christian T Ruff.;Elliott M Antman.;Anthony P Carnicelli.;John W Eikelboom.;Christopher B Granger.;Manesh R Patel.;Lars Wallentin.;Robert P Giugliano.
来源: Circulation. 2026年153卷8期567-575页
Systemic embolic events (SEEs) are a serious but underrecognized complication of atrial fibrillation. Although non-vitamin K antagonist oral anticoagulants prevent ischemic stroke (IS), their efficacy in SEE and the clinical characteristics of patients who experience SEE remain poorly understood.
6. Drug-Eluting Stent, Drug-Coated Balloon, or Plain Old Balloon Angioplasty for In-Stent Coronary Restenosis: Insights From a Mixed Treatment Comparison Meta-Analysis of Randomized Trials.
作者: M Haisum Maqsood.;Robert S Zhang.;Nil Rawal.;Gal Sella.;Neal S Kleiman.;Sripal Bangalore.
来源: Circ Cardiovasc Interv. 2025年18卷12期e015161页
Drug-coated balloons (DCBs) are now a Food and Drug Administration-approved treatment option for the management of in-stent restenosis (ISR) based on superior outcomes compared with plain old balloon angioplasty (POBA) alone. However, the efficacy of DCB compared with drug-eluting stent (DES; repeat stenting) for ISR is uncertain, with prior studies showing inferiority of DCB. We aimed to compare the outcomes of DES, DCB, or POBA in patients with coronary ISR.
7. Comparison of Limus and Paclitaxel Drug-Coated Balloons, Second-Generation or Newer Drug-Eluting Stents, and Balloon Angioplasty: A Network Meta-Analysis of Randomized Controlled Trials.
作者: Yuko Kiyohara.;Tadao Aikawa.;Tetsuya Saito.;Abel Casso Dominguez.;Jose Wiley.;Dhaval Kolte.;Eric A Secemsky.;Robert W Yeh.;Roger J Laham.;Azeem Latib.;Deepak L Bhatt.;Toshiki Kuno.
来源: Circ Cardiovasc Interv. 2026年19卷1期e016005页
It remains unclear whether drug-coated balloons (DCBs) and drug-eluting stents are comparable in the treatment of coronary artery disease (CAD) and whether limus versus paclitaxel DCBs yield similar clinical outcomes. We aimed to assess the clinical efficacy of limus and paclitaxel DCBs in patients with CAD through a network meta-analysis.
8. Five-Year Clinical Outcomes and Durability of a Self-Expanding Transcatheter Heart Valve With Intra-Annular Leaflets.
作者: Rishi Puri.;Holger Thiele.;Stephan Fichtlscherer.;Dirk Westermann.;Raj Makkar.;Ron Waksman.;Samer Hakmi.;Lars Sondergaard.;Mark Groh.;Joseph K Montarello.;Joerg Kempfert.;Gerald Yong.;Francesco Bedogni.;Francesco Maisano.;Stephen G Worthley.;Josep Rodes-Cabau.;Gregory P Fontana.;Helge Möllmann.
来源: Circ Cardiovasc Interv. 2025年18卷12期e015430页
There is a paucity of data regarding the longer-term durability of transcatheter heart valves. This analysis aimed to describe the 5-year clinical outcomes and valve durability for patients treated with the Portico transcatheter heart valves across 3 studies harmonized in their prospective enrollment, inclusion/exclusion criteria, centralized independent core laboratory echocardiographic analysis, and independent clinical events committee adjudication.
9. Comparative Effectiveness of TAVI Platforms and Surgical Aortic Valve Replacement: A Network Meta-Analysis of Randomized Controlled Trials.
作者: Francesco Moroni.;Pablo Lamelas.;Ariel Izcovich.;Farid Foroutan.;Stephen E Fremes.;Ana Carolina Alba.;Thomas Agoritsas.;Richard Whitlock.;Martin Denicolai.;Oscar Mendiz.;Mamas A Mamas.;Rodrigo Bagur.
来源: Circ Cardiovasc Interv. 2025年18卷10期e015387页
Evidence informing clinical guidelines assumes that all transcatheter aortic valve implantation (TAVI) devices have similar effectiveness, in other words, displaying a class effect across TAVI valves. We aimed to assess the comparative effectiveness of different TAVI platforms relative to other TAVI counterparts or surgical aortic valve replacement (SAVR).
10. Network Meta-Analysis of Quality of Life in Heart Failure With Reduced Ejection Fraction.
作者: Robert Margaryan.;Nariman Sepehrvand.;Wouter Ouwerkerk.;Jasper Tromp.;Ricky D Turgeon.;Justin A Ezekowitz.
来源: Circ Heart Fail. 2025年18卷12期e013074页
Although the effects of various combinations of treatments on mortality and morbidity outcomes in heart failure with reduced ejection fraction (HFrEF) have been evaluated, the impact on quality of life is unknown. This study evaluated and compared the composite impact of pharmacological therapies on quality of life in HFrEF using a frequentist network meta-analysis and systematic review methodology.
11. Dapagliflozin in Patients Hospitalized for Heart Failure: Primary Results of the DAPA ACT HF-TIMI 68 Randomized Clinical Trial and Meta-Analysis of Sodium-Glucose Cotransporter-2 Inhibitors in Patients Hospitalized for Heart Failure.
作者: David D Berg.;Siddharth M Patel.;Paul M Haller.;Abby L Cange.;Michael G Palazzolo.;Andrea Bellavia.;Julia F Kuder.;Akshay S Desai.;Silvio E Inzucchi.;John J V McMurray.;Eileen O'Meara.;Subodh Verma.;Jan Bělohlávek.;Jarosław Drożdż.;Béla Merkely.;Modele O Ogunniyi.;Tomáš Drasnar.;Joseph L Izzo.;Balazs Sarman.;John E McGinty.;Krishnan Ramanathan.;Angel J Mulkay.;Andrzej Przybylski.;Christian T Ruff.;Michelle L O'Donoghue.;Sabina A Murphy.;Marc S Sabatine.;Stephen D Wiviott.; .
来源: Circulation. 2025年152卷20期1411-1422页
SGLT2 (sodium-glucose cotransporter-2) inhibitors reduce the risk of cardiovascular death or worsening heart failure (HF) in outpatients with HF. Data on initiation in patients hospitalized for HF are limited.
12. Genetic Variants Associated With Congenital Heart Disease: A Meta-Analysis of Ethnicity and Subtype-Specific Susceptibility.
Congenital heart disease (CHD) is the most common heterogeneous birth defect, with prevalence varying across populations. A comprehensive meta-analysis could refine the genetic risk estimates and enhance our understanding of CHD susceptibility.
13. Cardiac CT Versus Transesophageal Echocardiography Following Left Atrial Appendage Closure: A Systematic Review and Meta-Analysis.
作者: Bryan E-Xin Tan.;Faiz Baqai.;Fernando Padilla.;Nadeem Nimri.;Jim W Cheung.;Anupama Kottam.;Hector M Medina.
来源: Circ Cardiovasc Imaging. 2025年18卷8期e018151页
In the landmark WATCHMAN trials, transesophageal echocardiography (TEE) was used to evaluate peri-device leak (PDL) and device-related thrombus (DRT) after percutaneous left atrial appendage closure (LAAC). We aimed to investigate the diagnostic utility of cardiac computed tomography angiography (CCTA) compared with TEE for post-LAAC device surveillance.
14. Dissecting the Genetic Architecture of Intracranial Aneurysms.
作者: Shaunak S Adkar.;Julie Lynch.;Ryan B Choi.;Tanmoy Roychowdhury.;Renae L Judy.;Kaavya Paruchuri.;Dong-Chuan Go.;Sharika Bamezai.;John Cabot.;Sabina Sorondo.;Michael G Levin.;Dianna M Milewicz.;Cristen J Willer.;Pradeep Natarajan.;Saiju Pyarajan.;Kyong-Mi Chang.;Scott Damrauer.;Phil Tsao.;Stephen Skirboll.;Nicholas J Leeper.;Derek Klarin.
来源: Circ Genom Precis Med. 2025年18卷3期e004626页
The genetic risk of intracranial aneurysm (IA) development has been ascribed to the genetic risk of smoking exposure and hypertension. The relationship of IA to other cardiovascular traits and the contribution of IA risk loci to aberrant gene programs within cerebrovascular cell types remains unclear.
15. Effect of TAVI on Epicardial Functional Indices and Their Relationship to Coronary Microvascular Function.
作者: Emanuele Gallinoro.;Roberto Scarsini.;Marco B Ancona.;Pasquale Paolisso.;Leonardo Portolan.;Paolo Springhetti.;Francesco Della Mora.;Andrea Mainardi.;Marta Belmonte.;Francesco Moroni.;Luca A Ferri.;Barbara Bellini.;Filippo Russo.;Ciro Vella.;Michele Mattia Viscusi.;Thabo Mahendiran.;Gabriele Pesarini.;Giovanni Benfari.;Matteo Montorfano.;Flavio Ribichini.;Marc Vanderheyden.;Emanuele Barbato.
来源: Circ Cardiovasc Interv. 2025年18卷6期e014940页
The anatomic and physiological changes associated with severe aortic stenosis may influence the functional evaluation of coronary stenoses. In this study, we aimed to assess changes in functional resting and hyperemic indices before and immediately after transcatheter aortic valve implantation (TAVI) and their relationship with microvascular resistance.
16. Optical Coherence Tomography Versus Angiography Alone to Guide PCI for Complex Lesions: A Meta-Analysis of Randomized Controlled Trials.
作者: Chidubem Ezenna.;Mrinal Murali Krishna.;Meghna Joseph.;Sammudeen Ibrahim.;Vinicius Pereira.;Ancy Jenil-Franco.;Michael G Nanna.;Sripal Bangalore.;Andrew M Goldsweig.
来源: Circ Cardiovasc Interv. 2025年18卷5期e015141页
Optical coherence tomography (OCT) provides high-resolution intracoronary imaging. However, whether the addition of OCT to angiography to guide percutaneous coronary intervention (PCI) of complex lesions affects clinical outcomes is debated.
17. Cost-Effectiveness of Aortic Valve Replacement in Low- and Intermediate-Risk Chinese Patients With Severe Aortic Stenosis.
作者: Jin Peng.;Xinglong Zheng.;Minghuan Jiang.;Xuelin Yao.;Yue Ma.;Mao Fu.;Tao Ma.;Xiaolong Shang.;Yang Yan.;Vinod H Thourani.;Yu Fang.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷4期e010858页
Transcatheter aortic valve replacement (TAVR) remains debated as an alternative to surgical aortic valve replacement (SAVR). We aimed to evaluate the cost-effectiveness of aortic valve replacement strategies in low- and intermediate-risk patients with severe aortic stenosis in China.
18. Early Versus Delayed Invasive Management of Female Patients With Non-ST-Elevation Acute Coronary Syndrome: An Individual Patient Data Meta-Analysis.
作者: Gregory B Mills.;Christos P Kotanidis.;Shamir Mehta.;Denise Tiong.;Erik A Badings.;Thomas Engstrøm.;Arnoud W J van 't Hof.;Dan Høfsten.;Lene Holmvang.;Alexander Jobs.;Lars Køber.;Dejan Milasinovic.;Aleksandra Milosevic.;Goran Stankovic.;Holger Thiele.;Roxana Mehran.;Vijay Kunadian.
来源: Circ Cardiovasc Interv. 2025年18卷3期e014763页
Female patients are at greater risk of adverse events following non-ST-elevation acute coronary syndrome but less frequently receive guideline-recommended coronary angiography and revascularization. Routine invasive management benefits high-risk patients, but evidence informing the optimal timing of angiography specifically in female patients is lacking.
19. Natural History, Phenotype Spectrum, and Clinical Outcomes of Desmin (DES)-Associated Cardiomyopathy.
作者: Babken Asatryan.;Marina Rieder.;Brittney Murray.;Steven A Muller.;Crystal Tichnell.;Alessio Gasperetti.;Richard T Carrick.;Emily Joseph.;Doris G Leung.;Anneline S J M Te Riele.;Stefan L Zimmerman.;Hugh Calkins.;Cynthia A James.;Andreas S Barth.
来源: Circ Genom Precis Med. 2025年18卷2期e004878页
Pathogenic/likely pathogenic (LP) desmin (DES) variants cause heterogeneous cardiomyopathy and skeletal myopathy phenotypes. Limited data suggest a high incidence of major adverse cardiac events (MACEs), including cardiac conduction disease, sustained ventricular arrhythmias (VA), and heart failure (HF) events (HF hospitalization, left ventricular assist device/cardiac transplant, HF-related death) in patients with pathogenic/LP DES variants. However, pleiotropic presentation and small cohort sizes have limited clinical phenotype and outcome characterization. We aimed to describe the natural history, phenotype spectrum, familial penetrance and outcomes in patients with pathogenic/LP DES variants through a systematic review and individual patient data meta-analysis using published reports.
20. Impact of Diagnosis to Ablation Time on Recurrence of Atrial Fibrillation and Clinical Outcomes After Catheter Ablation: A Systematic Review and Meta-Analysis With Reconstructed Time-to-Event Data.
作者: Ahmed Mazen Amin.;Hossam Elbenawi.;Ubaid Khan.;Omar Almaadawy.;Mustafa Turkmani.;Wael Abdelmottaleb.;Mohammed Essa.;Mohamed Abuelazm.;Basel Abdelazeem.;Zain Ul Abideen Asad.;Abhishek Deshmukh.;Mark S Link.;Christopher V DeSimone.
来源: Circ Arrhythm Electrophysiol. 2025年18卷2期e013261页
Current clinical guidelines emphasize the significance of rhythm control with catheter ablation but lack guidance on the timing of atrial fibrillation (AF) ablation relative to the diagnosis time. We aim to investigate the latest evidence on the impact of diagnosis to ablation time (DAT) on clinical outcomes after AF ablation.
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