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1861. Risk factors in patients with COVID-19 developing severe liver injury during hospitalisation.
作者: Ke Zhan.;Shengtao Liao.;Jinfang Li.;Yang Bai.;Lin Lv.;Keqi Yu.;Liewang Qiu.;Chuanfei Li.;Guodan Yuan.;An Zhang.;Zhechuan Mei.
来源: Gut. 2021年70卷3期628-629页 1862. Naturally occurring 5' preS1 deletions markedly enhance replication and infectivity of HBV genotype B and genotype C.
作者: Jing Li.;Jisu Li.;Shiqi Chen.;Quan Yuan.;Jing Zhang.;Jingwen Wu.;Qirong Jiang.;Qianru Wang.;Ning-Shao Xia.;Jiming Zhang.;Shuping Tong.
来源: Gut. 2021年70卷3期575-584页
Deletion of 15-nucleotide or 18-nucleotide (nt) covering preS1 ATG frequently arises during chronic infection with HBV genotypes B and C. Since the second ATG is 33nt downstream, they truncate large (L) envelope protein by 11 residues like wild-type genotype D. This study characterised their functional consequences.
1863. Location-specific cell identity rather than exposure to GI microbiota defines many innate immune signalling cascades in the gut epithelium.
作者: Ozge Kayisoglu.;Franziska Weiss.;Carolin Niklas.;Isabella Pierotti.;Malvika Pompaiah.;Nina Wallaschek.;Christoph-Thomas Germer.;Armin Wiegering.;Sina Bartfeld.
来源: Gut. 2021年70卷4期687-697页
The epithelial layer of the GI tract is equipped with innate immune receptors to sense invading pathogens. Dysregulation in innate immune signalling pathways is associated with severe inflammatory diseases, but the responsiveness of GI epithelial cells to bacterial stimulation remains unclear.
1865. International trends in oesophageal cancer survival by histological subtype between 1995 and 2014.
作者: Eileen Morgan.;Isabelle Soerjomataram.;Anna T Gavin.;Mark J Rutherford.;Piers Gatenby.;Aude Bardot.;Jacques Ferlay.;Oliver Bucher.;Prithwish De.;Gerda Engholm.;Christopher Jackson.;Serena Kozie.;Alana Little.;Bjorn Møller.;Lorraine Shack.;Hanna Tervonen.;Vicky Thursfield.;Sally Vernon.;Paul M Walsh.;Ryan R Woods.;Christian Finley.;Neil Merrett.;Dianne L O'Connell.;John V Reynolds.;Freddie Bray.;Melina Arnold.
来源: Gut. 2021年70卷2期234-242页
Survival from oesophageal cancer remains poor, even across high-income countries. Ongoing changes in the epidemiology of the disease highlight the need for survival assessments by its two main histological subtypes, adenocarcinoma (AC) and squamous cell carcinoma (SCC).
1866. Very early-life exposure to microbiota-induced TNF drives the maturation of neonatal pre-cDC1.
作者: Arnaud Köhler.;Sandrine Delbauve.;Justine Smout.;David Torres.;Véronique Flamand.
来源: Gut. 2021年70卷3期511-521页
Induction of immune protection against pathogens is particularly crucial during the neonatal period dominated by anti-inflammatory and tolerance immunity. The preclinical study was carried out to determine whether environmental factors such as microbiota may influence early life immunity by impacting the development and the functional maturation of precursors of type 1 conventional dendritic cells (pre-cDC1), endowed with regulatory properties.
1867. Ranking microbiome variance in inflammatory bowel disease: a large longitudinal intercontinental study.
作者: Adam G Clooney.;Julia Eckenberger.;Emilio Laserna-Mendieta.;Kathryn A Sexton.;Matthew T Bernstein.;Kathy Vagianos.;Michael Sargent.;Feargal J Ryan.;Carthage Moran.;Donal Sheehan.;Roy D Sleator.;Laura E Targownik.;Charles N Bernstein.;Fergus Shanahan.;Marcus J Claesson.
来源: Gut. 2021年70卷3期499-510页
The microbiome contributes to the pathogenesis of inflammatory bowel disease (IBD) but the relative contribution of different lifestyle and environmental factors to the compositional variability of the gut microbiota is unclear.
1868. Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing.
作者: Min Zhang.;Shuofeng Hu.;Min Min.;Yanli Ni.;Zheng Lu.;Xiaotian Sun.;Jiaqi Wu.;Bing Liu.;Xiaomin Ying.;Yan Liu.
来源: Gut. 2021年70卷3期464-475页
Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular and cellular heterogeneity in GA using single-cell RNA sequencing (scRNA-seq).
1869. SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation.
作者: Lea Južnić.;Kenneth Peuker.;Anne Strigli.;Mario Brosch.;Alexander Herrmann.;Robert Häsler.;Michael Koch.;Liz Matthiesen.;Yvonne Zeissig.;Britt-Sabina Löscher.;Alexander Nuber.;Gunnar Schotta.;Volker Neumeister.;Triantafyllos Chavakis.;Thomas Kurth.;Mathias Lesche.;Andreas Dahl.;Anne von Mässenhausen.;Andreas Linkermann.;Stefan Schreiber.;Konrad Aden.;Philip C Rosenstiel.;Andre Franke.;Jochen Hampe.;Sebastian Zeissig.
来源: Gut. 2021年70卷3期485-498页
The intestinal epithelium is a rapidly renewing tissue which plays central roles in nutrient uptake, barrier function and the prevention of intestinal inflammation. Control of epithelial differentiation is essential to these processes and is dependent on cell type-specific activity of transcription factors which bind to accessible chromatin. Here, we studied the role of SET Domain Bifurcated Histone Lysine Methyltransferase 1, also known as ESET (SETDB1), a histone H3K9 methyltransferase, in intestinal epithelial homeostasis and IBD.
1870. Neither black nor white: do altered intestinal microbiota reflect chronic liver disease severity?
作者: Felix Goeser.;Philipp Münch.;Till Robin Lesker.;Philipp Ludwig Lutz.;Benjamin Krämer.;Dominik J Kaczmarek.;Claudia Finnemann.;Hans Dieter Nischalke.;Robert Geffers.;Marijo Parcina.;Alice McHardy.;Christian Strassburg.;Achim Hoerauf.;Jacob Nattermann.;Isabelle Bekeredjian-Ding.;Ulrich Spengler.
来源: Gut. 2021年70卷2期438-440页 1871. Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score.
作者: Waku Hatta.;Yosuke Tsuji.;Toshiyuki Yoshio.;Naomi Kakushima.;Shu Hoteya.;Hisashi Doyama.;Yasuaki Nagami.;Takuto Hikichi.;Masakuni Kobayashi.;Yoshinori Morita.;Tetsuya Sumiyoshi.;Mikitaka Iguchi.;Hideomi Tomida.;Takuya Inoue.;Tomoyuki Koike.;Tatsuya Mikami.;Kenkei Hasatani.;Jun Nishikawa.;Tomoaki Matsumura.;Hiroko Nebiki.;Dai Nakamatsu.;Ken Ohnita.;Haruhisa Suzuki.;Hiroya Ueyama.;Yoshito Hayashi.;Mitsushige Sugimoto.;Shinjiro Yamaguchi.;Tomoki Michida.;Tomoyuki Yada.;Yoshiro Asahina.;Toshiaki Narasaka.;Shiko Kuribasyashi.;Shu Kiyotoki.;Katsuhiro Mabe.;Tomohiro Nakamura.;Naoki Nakaya.;Mitsuhiro Fujishiro.;Atsushi Masamune.
来源: Gut. 2021年70卷3期476-484页
Bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is a frequent adverse event after ESD. We aimed to develop and externally validate a clinically useful prediction model (BEST-J score: Bleeding after ESD Trend from Japan) for bleeding after ESD for EGC.
1872. Epidemiology and outcomes of gastroparesis, as documented in general practice records, in the United Kingdom.
作者: Yizhou Ye.;Baoguo Jiang.;Sudhakar Manne.;Peter L Moses.;Cristina Almansa.;Dimitri Bennett.;Paul Dolin.;Alexander C Ford.
来源: Gut. 2021年70卷4期644-653页
To generate real-world evidence for the epidemiology of gastroparesis in the UK, we evaluated the prevalence, incidence, patient characteristics and outcomes of gastroparesis in the Clinical Practice Research Datalink (CPRD) database.
1873. Prevalence, risk factors and clinical outcomes of COVID-19 in patients with a history of pancreatitis in Northern California.
作者: John Gubatan.;Steven Levitte.;Akshar Patel.;Tatiana Balabanis.;Arpita Sharma.;Elaina Jones.;Bomi Lee.;Murli Manohar.;Gayathri Swaminathan.;Walter Park.;Aida Habtezion.
来源: Gut. 2021年70卷2期440-441页 1875. Colon and rectal cancer survival in seven high-income countries 2010-2014: variation by age and stage at diagnosis (the ICBP SURVMARK-2 project).
作者: Marzieh Araghi.;Melina Arnold.;Mark J Rutherford.;Marianne Grønlie Guren.;Citadel J Cabasag.;Aude Bardot.;Jacques Ferlay.;Hanna Tervonen.;Lorraine Shack.;Ryan R Woods.;Nathalie Saint-Jacques.;Prithwish De.;Carol McClure.;Gerda Engholm.;Anna T Gavin.;Eileen Morgan.;Paul M Walsh.;Christopher Jackson.;Geoff Porter.;Bjorn Møller.;Oliver Bucher.;Michael Eden.;Dianne L O'Connell.;Freddie Bray.;Isabelle Soerjomataram.
来源: Gut. 2021年70卷1期114-126页
As part of the International Cancer Benchmarking Partnership (ICBP) SURVMARK-2 project, we provide the most recent estimates of colon and rectal cancer survival in seven high-income countries by age and stage at diagnosis.
1876. Inflammatory bowel disease and risk of small bowel cancer: a binational population-based cohort study from Denmark and Sweden.
作者: Jordan E Axelrad.;Ola Olén.;Michael C Sachs.;Rune Erichsen.;Lars Pedersen.;Jonas Halfvarson.;Johan Askling.;Anders Ekbom.;Henrik Toft Sørensen.;Jonas F Ludvigsson.
来源: Gut. 2021年70卷2期297-308页
Crohn's disease (CD) is associated with increased risk of small bowel cancer (SBC), but previous studies have been small. We aimed to examine the risk of incident SBC and death from SBC in patients with inflammatory bowel disease (IBD).
1877. Number of reflux episodes on pH-impedance monitoring associates with improved symptom outcome and treatment satisfaction in gastro-oesophageal reflux disease (GERD) patients with regurgitation.
作者: Benjamin D Rogers.;Luis R Valdovinos.;Michael D Crowell.;Reginald Bell.;Marcelo F Vela.;C Prakash Gyawali.
来源: Gut. 2021年70卷3期450-455页
Number of reflux episodes, an adjunctive metric on pH-impedance monitoring, is incompletely studied. We aimed to determine if number of reflux episodes associates with therapeutic outcome in regurgitation predominant gastro-oesophageal reflux disease (GERD).
1879. Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies.
作者: Lucille Quénéhervé.;Raphael Olivier.;Michalina J Gora.;Céline Bossard.;Jean-François Mosnier.;Emilie Benoit A la Guillaume.;Claude Boccara.;Charlène Brochard.;Michel Neunlist.;Emmanuel Coron.
来源: Gut. 2021年70卷1期6-8页
Full-field optical coherence tomography (FFOCT) is an imaging technique of biological tissue based on tissue light reflectance analysis. We evaluated the feasibility of imaging fresh digestive mucosal biopsies after a quick mounting procedure (5 min) using two distinct modalities of FFOCT. In static FFOCT mode, we gained high-resolution images of general gut tissue-specific architecture, such as oesophageal papillae, gastric pits, duodenal villi and colonic crypts. In dynamic FFOCT mode, we imaged individual epithelial cells of the mucosal lining with a cellular or subcellular resolution and identified cellular components of the lamina propria. FFOCT represents a promising dye-free imaging tool for on-site analysis of gut tissue remodelling.
1880. Reflux symptoms and oesophageal acidification in treated achalasia patients are often not reflux related.
作者: Fraukje A Ponds.;Jacobus M Oors.;André J P M Smout.;Albert J Bredenoord.
来源: Gut. 2021年70卷1期30-39页
After treatment, achalasia patients often develop reflux symptoms. Aim of this case-control study was to investigate mechanisms underlying reflux symptoms in treated achalasia patients by analysing oesophageal function, acidification patterns and symptom perception.
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