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141. Effects of a probiotic fermented dairy product on hippocampal metabolites, structure and function: an 8-week randomised, placebo-controlled trial in healthy women.
作者: Wolfgang Marx.;Chao Suo.;Thusharika Dissanayaka.;Suzan Maleki.;Liam Nguyen.;Nikolaj Travica.;Mohammadreza Mohebbi.;Mojtaba Lotfaliany.;Murat Yucel.;Amelia J McGuinness.;Michael Berk.;Hajara Aslam.;Felice N Jacka.
来源: Gut. 2025年75卷3期
Fermented foods are a promising yet underexplored intervention for influencing brain function and mental health through the gut-brain axis.
142. Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer.
作者: Annika Osswald.;Esther Wortmann.;David Wylensek.;Stephanie Kuhls.;Olivia I Coleman.;Kenneth Peuker.;Anne Strigli.;Quinten R Ducarmon.;Martin Larralde.;Wei Liang.;Nicole S Treichel.;Fabian Schumacher.;Colin Volet.;Silke Matysik.;Karin Kleigrewe.;Michael Gigl.;Sascha Rohn.;Chun-Jun Guo.;Burkhard Kleuser.;Gerhard Liebisch.;Angelika Schnieke.;Jason M Ridlon.;Rizlan Bernier-Latmani.;Georg Zeller.;Sebastian Zeissig.;Dirk Haller.;Krzysztof Flisikowski.;Thomas Clavel.;Soeren Ocvirk.
来源: Gut. 2025年
Western diet and associated production of secondary bile acids (BAs) have been linked to the development of sporadic colorectal cancer (CRC). Despite observational studies showing that secondary BAs produced by 7α-dehydroxylating (7αDH+) gut bacteria are increased in CRC, a causal proof of their tumour-promoting effects is lacking.
145. PCK1 deficiency promotes MASH-HCC progression by 12-HETE-induced CD8+ T cell dysfunction.
作者: Kang Wu.;Luo Li.;Yi Liu.;Kai Wang.;Jianghong Zheng.;Huijun Liang.;Fengli Xu.;Renming Liu.;Chang Chen.;Luyi Huang.;Haijun Deng.;Xiaojian Han.;Shi Chen.;Zhirong Zhang.;Xinyu Liu.;Qiang He.;Xiaosong Li.;Aishun Jin.;Ailong Huang.;Ni Tang.
来源: Gut. 2025年
Metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma (MASH-HCC) has been reported to be less responsive to immune checkpoint inhibitors, which may be associated with metabolic reprogramming of tumour cells and abnormal tumour microenvironment.
146. "DPP- 4 inhibitor alleviates gut-brain axis Parkinson's disease pathology" - can dipeptidyl peptidase 4 inhibitors be repurposed as disease-modifying drugs for body-first Parkinson's disease patients?147. CD177+ neutrophils drive extracellular matrix remodelling and HGF-alpha release in ALPPS-induced liver regeneration.
作者: Jiayan Yan.;Ao Huang.;Shiyu Zhang.;Na Yao.;Junfeng Huang.;Zhifeng Jiang.;Jiayi Wang.;Feiyu Chen.;Qichao Yu.;Jianwen Cheng.;Senquan Zhang.;Tianyi Li.;Rongshan Gao.;Runze Miao.;Rongkui Luo.;Shaolai Zhou.;Yuan Ji.;Zheng Wang.;Dongmei Gao.;Zhenbin Ding.;Zhaoyou Tang.;Jia Fan.;Miguel A Esteban.;Hans Jürgen Schlitt.;Xinrong Yang.;Jian Zhou.
来源: Gut. 2025年
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) effectively induces rapid liver hypertrophy in patients with initially unresectable liver tumours, yet the immunological mechanisms remain unclear.
148. Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn's disease.
作者: Longyuan Zhou.;Jing Nie.;Zhiyin Feng.;Rongchang Li.;Pingxin Zhang.;Sinan Lin.;Yao Zhang.;Florian Rieder.;Changhao Chen.;Minhu Chen.;Ren Mao.
来源: Gut. 2026年75卷5期905-919页
Intestinal fibrosis, a hallmark complication of Crohn's disease (CD), frequently progresses to stricture formation and surgical intervention. Fibroblast metabolic reprogramming is important in organ fibrosis. However, its role in intestinal fibrogenesis of CD remains elusive.
149. Spatial transcriptomics defines the molecular progression, invasion and immune landscape of IPMN and IPMN-derived pancreatic cancer.
作者: Ming Cui.;Shengwei Mo.;Jialu Bai.;Ammar A Javed.;Joseph R Habib.;Sen Yang.;Tianqi Chen.;Ruiling Xiao.;Wenfei Diao.;Decheng Jiang.;Christopher L Wolfgang.;Xiaoyan Chang.;Ya Hu.;Yupei Zhao.
来源: Gut. 2026年75卷4期801-814页
Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic cancer with highly variable malignant potential. Current understanding of their biology remains incomplete, limiting accurate risk stratification and targeted interventions.
150. Preclinical stages of Crohn's disease defined by faecal calprotectin in asymptomatic first-degree relatives: screening framework for prevention trials.
作者: Dan Turner.;Sarah Kenigsberg.;Gili Focht.;Williams Turpin.;Oren Ledder.;Anne M Griffiths.;Hien Q Huynh.;Luba Plotkin.;Yonat Aharoni-Frutkoff.;Wael El-Matary.;Anthony R Otley.;Irit Avni-Biron.;Kevan Jacobson.;Remo Panaccione.;Joana Torres.;Sun-Ho Lee.;Kenneth Croitoru.
来源: Gut. 2026年
The PIONIR (Preventing IBD ONset in Individuals at Risk) trial evaluates whether the Tasty&Healthy diet can reduce risk of Crohn's disease (CD) development in first-degree relatives (FDRs). The optimal preclinical stage of CD for enrolling subjects to prevention trials is unknown.
155. Autophagy of Kupffer cells modulates CD8+ T cell activation in primary biliary cholangitis.
作者: Pan-Yue Luo.;Min Ma.;Meng-Chu Liu.;Ye-Hui Wu.;Jie Long.;Meng-Xing Huang.;Si-Yu Yang.;Tian-Tian Da.;Koichi Tsuneyama.;Qiao Li.;Haosheng Jin.;Zhi-Bin Zhao.;Jun Wang.;Xiong Ma.;Merrill Eric Gershwin.;Ying Han.;Zhe-Xiong Lian.;Liang Li.
来源: Gut. 2025年
Kupffer cells and monocyte-derived macrophages (MoMs) are difficult to study in human primary biliary cholangitis (PBC) even though they reflect a dynamic hepatic immune population.
157. Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection.
作者: Anucha Preechanukul.;Aljawharah Alrubayyi.;Bo Sun.;Edward Arbe-Barnes.;Jonida Kokici.;Frances Gorou.;Sarun Prasitdumrong.;Kelly A S da Costa.;Natasha Fisher-Pearson.;Noshin Hussain.;Stephanie Kucykowicz.;Indrajit Ghosh.;Fiona Burns.;Sabine Kinloch.;Pedro Simoes.;Sanjay Bhagani.;Patrick T F Kennedy.;Mala K Maini.;Rachael Bashford-Rogers.;Upkar S Gill.;Dimitra Peppa.
来源: Gut. 2025年
Chronic hepatitis B virus (HBV) infection disproportionately affects people living with HIV, who are often excluded from functional cure studies.
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