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121. A 27-Year-Old Woman With Rapidly Progressive Shortness of Breath and Severe Alopecia.
A 27-year-old previously healthy woman with no known exposure history presented with a 20-day history of progressively worsening breathlessness. She progressed from being breathless while hurrying on level ground to becoming breathless at rest and unable to complete sentences within 2 days. She reported multiple episodes of hemoptysis (approximately 30 mL daily) over the past 6 to 7 days, along with generalized weakness and fatigue for the last 7 days, and sudden onset of hair loss for the past 2 days. She reported episodic bluish discoloration of fingers on exposure to cold for the last 3 years but denied history of joint pain or skin rash.
122. Management of Pulmonary Granulomatous Venulitis by Lung Transplantation.
作者: Ariel M McKenna.;Anupama Tiwari.;Amit Chopra.;Llewellyn Foulke.;Maria M Crespo.;Harrison W Farber.
来源: Chest. 2025年168卷3期e59-e63页
Granulomatous venulitis is an exceedingly rare condition characterized by granulomatous inflammation and obliteration of small pulmonary veins, leading to the development of pulmonary venoocclusive disease. The prognosis is poor, with most patients surviving less than 1 year after diagnosis. We present the first case, to our knowledge, of successful management of this disease by lung transplantation.
133. Pediatric Bronchiectasis Action Management Plan to Improve Clinical Outcomes: A Randomized Controlled Trial.
作者: Kobi L Schutz.;Anne B Chang.;Lesley A Versteegh.;Stephanie T Yerkovich.;Peter S Morris.;Pamela Laird.;Andre Schultz.;Julie M Marchant.;Gabrielle B McCallum.
来源: Chest. 2025年168卷5期1097-1106页
Managing bronchiectasis exacerbations is a priority for patients, parents, and caregivers of children with bronchiectasis. However, evidence-based strategies among the pediatric population remain limited.
134. How Using Different Oximeters May Affect Clinical Decision-Making: A Method Comparison Study in Patients Receiving CPAP or Noninvasive Ventilation.
Nocturnal pulsed oxygen saturation (SpO2) monitoring is recommended for detecting residual sleep-disordered breathing, including nocturnal hypoventilation, in patients treated by noninvasive ventilation (NIV) or CPAP. It is a general assumption that different pulse oximetry devices will provide similar results. However, this may not be correct.
135. Novel Hypoglossal Stimulation Markedly Improves Airflow and Airway Collapsibility in OSA.
作者: Amal M Osman.;A Simon Carney.;Eng H Ooi.;Himani Joshi.;Barbara Toson.;Carolin Tran.;Anna L Hudson.;Phuc Nguyen.;Nick Gelekis.;Peter R Eastwood.;Peter Catcheside.;Danny J Eckert.
来源: Chest. 2025年
Hypoglossal nerve stimulation (HNS) to treat OSA currently requires placement of a cuff or so-called saddle electrode around or adjacent to the hypoglossal nerve or nerves. Limitations for this therapy include cost, invasiveness, and variable efficacy.
136. Digital Respiratory Technologies Across the Lifespan: An Overview of Opportunities and Challenges From Children to Older Adults.
Digital health technologies (DHTs), such as mobile health technologies, wearables, telehealth, and telemonitoring, are used increasingly in health care. This is particularly true for respiratory conditions such as asthma, cystic fibrosis, TB, interstitial lung disease, and COPD because DHTs can support diagnosis, self-management, and ongoing care. However, respiratory conditions change across an individual's lifespan in both their presentation and management priorities for the clinician and patient. This creates new challenges and opportunities for using DHTs. Adopting an all-of-life approach is key when considering DHT use within each life stage and across the lifespan.
137. Sepsis-Induced Cardiomyopathy: Mechanism, Prevalence, Assessment, Prognosis, and Management.
作者: Ryota Sato.;Filippo Sanfilippo.;Michael Lanspa.;Abhijit Duggal.;Siddharth Dugar.
来源: Chest. 2025年
Sepsis-induced cardiomyopathy (SICM) is a heterogeneous cardiovascular dysfunction associated with sepsis and septic shock. Although traditionally defined by reversible left ventricular (LV) systolic dysfunction, recent evidence has revealed a broader spectrum, including LV diastolic dysfunction, hyperdynamic LV systolic states, and right ventricular (RV) injury, occurring independently or in combination. Despite their prognostic significance, these phenotypes remain underrecognized and understudied.
138. Implementing a Precision Medicine Thoracic Service Using In-House Reflex Testing in a Large Academic-Community Practice.
作者: Debora S Bruno.;Matthew M Mirsky.;Andrea L Donner.;Shelby R Kopp.;Mehul Jani.;Wadad Mneimneh.;Jennifer M Yoest.;Seunghee P Margevicius.;John Shanahan.;Pingfu Fu.;Melinda L Hsu.;Qian Wang.;Lauren S Chiec.;Giselle A Dutcher.;Sean Cho.;Afshin Dowlati.;Johnie Rose.;Navid Sadri.
来源: Chest. 2025年
Broad genomic testing is necessary to treat patients with stage IV non-small cell lung cancer (NSCLC). This article describes a NSCLC precision medicine service at an academic-community practice and provides model-based estimates of the impact of a similar intervention.
139. The Dose-Response of Inhaled Corticosteroids in Combination Inhaled Corticosteroid/Long Acting Beta2-Agonist Maintenance Therapy for Asthma: A Systematic Review and Meta-Analysis.
作者: Jonathan H Noble.;Samantha Warhurst.;Ryan Cullen.;Ross Sayers.;Francesca Lynch.;Joseph Kulathinal.;Mark Weatherall.;Richard W Beasley.
来源: Chest. 2025年
High doses of a maintenance inhaled corticosteroids (ICSs) in asthma may achieve only modest additional clinical benefit beyond low-to-medium doses and are associated with an increased risk of adverse systemic effects. The ICS dose-response relationship when administered as maintenance combination ICS/long-acting beta2-agonist (LABA) therapy is uncertain.
140. Comparison of Underlying Risk of Lung Cancer Developing and Death Resulting in Screened Populations.
作者: M Patricia Rivera.;Thad Benefield.;Danielle D Durham.;Jennifer L Lund.;Daniel S Reuland.;Li C Cheung.;Lindsay M Lane.;Hormuzd A Katki.;Louise M Henderson.
来源: Chest. 2025年
Trial participants typically are healthier than the general population. Differences in underlying characteristics between the population undergoing lung cancer screening (LCS) and LCS trial participants may alter the benefits of LCS.
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