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101. Resuscitation From Out-of-Hospital Cardiac Arrest When Is EtCO2 Reliably Associated With ROSC?
作者: Michelle M J Nassal.;Rachel M Smith.;Elisabete Aramendi.;Andoni Elola.;Xabier Jaureguibeitia.;Ahamed Idris.;Mohamud R Daya.;Jestin Carlson.;Tom Aufderheide.;Graham Nichol.;Ashish R Panchal.;Henry E Wang.
来源: Circulation. 2026年
Exhaled end-tidal carbon dioxide (EtCO2) trajectory is associated with out-of-hospital cardiac arrest (OHCA) outcomes. However, the minimum EtCO2 monitoring duration needed to discriminate return of spontaneous circulation (ROSC) from non-ROSC remains unknown. We sought to determine the EtCO2 trajectory observation time required to differentiate ROSC from non-ROSC patients.
102. Comparative Efficacy of Transfusion Strategies in Women and Men With Myocardial Infarction and Anemia: Prespecified Secondary Findings From the MINT Trial.
作者: J Dawn Abbott.;Jocelyne R Benatar.;Colleen M Ballantyne.;Alice K Jacobs.;Andrew M Goldsweig.;Dean A Fergusson.;Brandon M Hebert.;Marnie Bertolet.;Tabassome Simon.;P Gabriel Steg.;Shaun G Goodman.;Harvey D White.;Jeffrey L Carson.;Maria M Brooks.; .
来源: Circulation. 2026年
The optimal transfusion strategy in patients with acute myocardial infarction (AMI) and anemia may be influenced by sex differences in pathophysiology and cardiovascular outcomes. The Myocardial Ischemia and Transfusion trial (MINT) randomized patients with AMI and anemia to restrictive or liberal transfusion thresholds, but sex-stratified outcomes remain undefined. The objective was to evaluate whether the clinical effect of restrictive versus liberal red blood cell transfusion strategies differs by sex in patients hospitalized with AMI and anemia.
103. Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients.
作者: Rick B Vega.;Gavin O'Mahony.;April M Barbour.;Hongtao Yu.;Jane Knöchel.;Johan Brengdahl.;Thomas Hochdörfer.;Linnéa Bergenholm.;Eva Töppner Carlsson.;Andrea Ahnmark.;Christina Rye Underwood.;Anna Rudvik.;Debra Carter.;Johanna Laru.;Aspen Gutgsell.;Lee Twaddle.;Pavlo Garkaviy.;Anna Bogstedt.;Eva Hurt-Camejo.;Tasso Miliotis.;Maria Ryaboshapkina.;Andrease Hober.;Brian Hubbard.;Michael Serrano-Wu.;Virendar Kaushik.;Stefan Geschwindner.;Michael C McCarthy.;Daniel Lindén.;Jaya B Rosenmeier.
来源: Circulation. 2026年
Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) is an effective therapy for reducing low-density lipoprotein (LDL) cholesterol (LDL-C) in adults with hyperlipidemia, including heterozygous familial hypercholesterolemia, thereby lowering cardiovascular risk. Current PCSK9 inhibitors are injectable therapies; no oral small-molecule PCSK9 inhibitor has yet been approved.
104. Response by Abd Razak et al to Letter Regarding Article, "Prospective Validation of the MIRACLE2 Score for Early Neurological Stratification After Out-of-Hospital Cardiac-Arrest: The GLOBAL-MIRACLE Registry".105. Letter by Lin et al Regarding Article, "Prospective Validation of the MIRACLE2 Score for Early Neurological Stratification After Out-of-Hospital Cardiac Arrest: The GLOBAL-MIRACLE Registry".107. Impact of the 2025 ASE Guidelines on the Classification of LV Diastolic Dysfunction in the Community: A Project Baseline Health Study.
作者: Nancy Herrera-Leaño.;Bettia Celestin.;Everton Santana.;Ryan Sandoval.;Gracia Fahed.;Patrick Khoury.;Jack W O'Sullivan.;Tatiana Kuznetsova.;Nicholas Cauwenberghs.;Kenneth W Mahaffey.;Pamela S Douglas.;Melissa Daubert.;Francois Haddad.
来源: Circ Cardiovasc Imaging. 2026年e019402页
The 2016 American Society of Echocardiography (ASE) guidelines for left ventricular diastolic dysfunction (LVDD) classification resulted in a significant proportion of indeterminate classifications and grades. To address these limitations and incorporate new evidence, the ASE updated its recommendations in 2025. The impact of these revisions in community cohorts remains unclear.
108. Assessing Left Atrial Volume Indexation to Predict Mortality in Individuals With Overweight or Obesity.
作者: Christine M Madronio.;Gary K K Low.;Nishant Nundlall.;David Playford.;Geoffrey Strange.;Faraz Pathan.;Kazuaki Negishi.
来源: Circ Cardiovasc Imaging. 2026年e019491页
Alternative indexation methods for left atrial volume (LAV) have been proposed to achieve better proportional scaling than the current standard body surface area indexation. However, there are limited data showing that these alternative indices provide long-term prognostic value in individuals with overweight or obesity. The aim of this study was to determine and compare the performance of various LAV indexation methods in predicting all-cause mortality in individuals with overweight or obesity.
111. Secondary Prevention After Coronary Artery Bypass Graft Surgery: 2026 Update: A Scientific Statement From the American Heart Association.
作者: Marc Ruel.;Sigrid Sandner.;Menaka Ponnambalam.;Chase Brown.;Mario Gaudino.;Louise Sun.;Subodh Verma.;Paul Poirier.; .
来源: Circulation. 2026年
Coronary artery bypass grafting is a well-established, durable, and safe surgical intervention. However, coronary artery disease continues to progress after the procedure. Patients who have undergone bypass surgery present unique challenges in terms of secondary prevention resulting from the often severe and diffuse nature of their coronary disease, the complexities of their postoperative recovery, the burden of their comorbid conditions, and the importance of ensuring long-term graft patency and preventing further disease progression. New evidence and advances in secondary prevention strategies in the post-coronary bypass grafting population have emerged since the American Heart Association's 2015 scientific statement on this topic. Secondary prevention strongly correlates with improved outcomes after bypass surgery, providing the rationale and urgency for this updated scientific statement to promote evidence-based practical considerations and to improve their use.
112. Use of Paclitaxel-Coated Balloons in the United States: Early Results From the AGENT Postapproval Study.
作者: Christina Lalani.;Eric Secemsky.;Yang Song.;Huaying Dong.;Ajay J Kirtane.;Saroj Neupane.;Amar Krishnaswamy.;Matthew J Price.;Rhian Davies.;Jarrod D Frizzell.;Kathleen E Kearney.;Jordan Safirstein.;Ziad A Ali.;Rafael Cavalcante.;Robert W Yeh.
来源: Circ Cardiovasc Interv. 2026年e016625页
AGENT is the only coronary drug-coated balloon (DCB) approved for treatment of in-stent restenosis (ISR) to date. In this study, we describe trends in DCB use and compare characteristics and in-hospital outcomes between patients who received DCB versus alternative treatments.
113. Measured Versus Predicted Prosthesis-Patient Mismatch after TAVR in Sievers Type 1 BAV: Incidence, Determinants, and Outcomes From the AD-HOC Registry.
作者: Tommaso Fabris.;Federico Arturi.;Andrea Buono.;Chiara de Biase.;Michele Bellamoli.;Andrea Zito.;Antonio Mangieri.;Nicholas Montarello.;Giuliano Costa.;Mesfer Alfadhel.;Ofi Koren.;Simone Fezzi.;Barbara Bellini.;Mauro Massussi.;Andrea Scotti.;Lin Bai.;Giulia Costa.;Alessandro Mazzapicchi.;Enrico Giacomin.;Riccardo Gorla.;Karsten Hug.;Carlo Briguori.;Luca Bettari.;Antonio Messina.;Mauro Boiago.;Matthias Renker.;Mario Garcia Gomez.;Massimo Napodano.;Chiara Fraccaro.;Luca Nai Fovino.;Giulia Masiero.;Francesco Cardaioli.;Francesco Putortì.;Andrea Panza.;Maria Luisa De Rosa.;Carlo Trani.;Giulia Laterra.;Alessia Latini.;Dario Pellegrini.;Alfonso Ielasi.;Ady Orbach.;Uri Landes.;Tobias Rheude.;Luca Testa.;Ignacio Amat Santos.;Francesco Saia.;Luca Favero.;Carlo Cernetti.;Mao Chen.;Marianna Adamo.;Azeem Latib.;Anna Sonia Petronio.;Matteo Montorfano.;Raj R Makkar.;Francesco Burzotta.;Marco Barbanti.;Daniel J Blackman.;Darren Mylotte.;Ole De Backer.;Didier Tchètchè.;Diego Maffeo.;Won-Keun Kim.;Giuseppe Tarantini.
来源: Circ Cardiovasc Interv. 2026年e015994页
Evidence regarding prosthesis-patient mismatch (PPM), measured (mPPM), and predicted (pPPM), after transcatheter aortic valve replacement in bicuspid aortic valve stenosis remains limited. This study sought to evaluate the incidence, predictors, and prognostic implications of mPPM and pPPM in patients with Sievers type 1 bicuspid aortic valve undergoing transcatheter aortic valve replacement.
114. Transforming Advanced Heart Failure Programs: Addressing Institutional and Systemic Drivers of Racial and Ethnic Disparities in Care.
作者: Debra D Dixon.;Sabra Lewsey.;Johanna Contreras.;Kevin Shah.;Jason Deen.;Khadijah Breathett.
来源: Circ Heart Fail. 2026年e012673页
Institutional and systemic practices and policies contribute to lower-quality care and adverse outcomes among diverse racial and ethnic groups and individuals with limited economic resources. There are ample opportunities to change the trajectory of patients with heart failure (HF) across racial and ethnic groups. Multiple studies and quality improvement initiatives have demonstrated strategies to improve the care of diverse racial and ethnic populations living with HF, yet dissemination remains limited. This state-of-the-art review examines structural racism in the context of HF, outlines evidence-based strategies for HF programs to improve access to advanced HF therapies and reduce disparities in treatment outcomes, and discusses priorities for implementation and dissemination science efforts to address structural causes of disparities in HF care.
117. Early Versus Late Initiation of Evolocumab and Arterial Aneurysm Events: An Analysis of FOURIER and FOURIER-OLE.
作者: Andre Zimerman.;Prakriti Gaba.;Michelle L O'Donoghue.;Robert P Giugliano.;Sabina A Murphy.;Xinhui Ran.;Julia F Kuder.;Richard Ceska.;Gaetano M De Ferrari.;Jorge Ferreira.;Zbigniew A Gaciong.;Jose Lopez-Sendon.;Alberto Lorenzatti.;José F K Saraiva.;J Wouter Jukema.;Maria-Laura Monsalvo.;Jose H Flores-Arredondo.;Dan Atar.;Anthony C Keech.;Marc S Sabatine.;Nicholas A Marston.;Brian A Bergmark.
来源: Circulation. 2026年153卷19期1516-1519页 118. Response by Turi et al to Letters Regarding Article, "Effect of Remote Ischemic Preconditioning on Myocardial Injury in Noncardiac Surgery: The PRINCE Randomized Clinical Trial".
作者: Stefano Turi.;Federico Mattia Oliva.;Rosa Labanca.;Giovanni Landoni.;Domenico Pontillo.
来源: Circulation. 2026年153卷19期e1302-e1303页 |