1143. Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial.
作者: Laura D Baker.;Mark A Espeland.;Rachel A Whitmer.;Heather M Snyder.;Xiaoyan Leng.;Laura Lovato.;Kathryn V Papp.;Melissa Yu.;Miia Kivipelto.;Ashley S Alexander.;Susan Antkowiak.;Maryjo Cleveland.;Claire Day.;Richard Elbein.;Sarah Tomaszewski Farias.;Deborah Felton.;Katelyn R Garcia.;Darren R Gitelman.;Sarah Graef.;Marjorie Howard.;Jeffrey Katula.;Katherine Lambert.;Olivia Matongo.;Anne Marie McDonald.;Valory Pavlik.;Rema Raman.;Stephen Salloway.;Christy Tangney.;Jennifer Ventrelle.;Sharon Wilmoth.;Benjamin J Willliams.;Rena Wing.;Nancy Woolard.;Maria C Carrillo.
来源: JAMA. 2025年334卷8期681-691页
Identifying new interventions to slow and prevent cognitive decline associated with dementia is critical. Nonpharmacological interventions targeting modifiable risk factors are promising, relatively low-cost, accessible, and safe approaches.
1149. Patent Foramen Ovale and Stroke: A Review.
A patent foramen ovale (PFO), an opening between the right and left atria during normal fetal development that fails to close after birth, is present in approximately 25% of all adults. Paradoxical embolism, a venous thromboembolism that travels to the systemic circulation typically through a PFO, accounts for about 5% of all strokes and 10% of strokes in younger patients.
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