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9441. Effect of Intravenous Interferon β-1a on Death and Days Free From Mechanical Ventilation Among Patients With Moderate to Severe Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.
作者: V Marco Ranieri.;Ville Pettilä.;Matti K Karvonen.;Juho Jalkanen.;Peter Nightingale.;David Brealey.;Jordi Mancebo.;Ricard Ferrer.;Alain Mercat.;Nicolò Patroniti.;Michael Quintel.;Jean-Louis Vincent.;Marjatta Okkonen.;Ferhat Meziani.;Giacomo Bellani.;Niall MacCallum.;Jacques Creteur.;Stefan Kluge.;Antonio Artigas-Raventos.;Mikael Maksimow.;Ilse Piippo.;Kati Elima.;Sirpa Jalkanen.;Markku Jalkanen.;Geoff Bellingan.; .
来源: JAMA. 2020年323卷8期725-733页
Acute respiratory distress syndrome (ARDS) is associated with high mortality. Interferon (IFN) β-1a may prevent the underlying event of vascular leakage.
9444. Effect of a Machine Learning-Derived Early Warning System for Intraoperative Hypotension vs Standard Care on Depth and Duration of Intraoperative Hypotension During Elective Noncardiac Surgery: The HYPE Randomized Clinical Trial.
作者: Marije Wijnberge.;Bart F Geerts.;Liselotte Hol.;Nikki Lemmers.;Marijn P Mulder.;Patrick Berge.;Jimmy Schenk.;Lotte E Terwindt.;Markus W Hollmann.;Alexander P Vlaar.;Denise P Veelo.
来源: JAMA. 2020年323卷11期1052-1060页
Intraoperative hypotension is associated with increased morbidity and mortality. A machine learning-derived early warning system to predict hypotension shortly before it occurs has been developed and validated.
9445. Association of Physician Orders for Life-Sustaining Treatment With ICU Admission Among Patients Hospitalized Near the End of Life.
作者: Robert Y Lee.;Lyndia C Brumback.;Seelwan Sathitratanacheewin.;William B Lober.;Matthew E Modes.;Ylinne T Lynch.;Corey I Ambrose.;James Sibley.;Kelly C Vranas.;Donald R Sullivan.;Ruth A Engelberg.;J Randall Curtis.;Erin K Kross.
来源: JAMA. 2020年323卷10期950-960页
Patients with chronic illness frequently use Physician Orders for Life-Sustaining Treatment (POLST) to document treatment limitations.
9447. Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China.
作者: Min Wei.;Jingping Yuan.;Yu Liu.;Tao Fu.;Xue Yu.;Zhi-Jiang Zhang.
来源: JAMA. 2020年323卷13期1313-1314页
This study characterizes the demographic, epidemiologic, and clinical characteristics of hospitalized infants diagnosed with coronavirus disease 2019 infection between December 8, 2019, and February 6, 2020, in China.
9451. Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial.
作者: François Lamontagne.;Alvin Richards-Belle.;Karen Thomas.;David A Harrison.;M Zia Sadique.;Richard D Grieve.;Julie Camsooksai.;Robert Darnell.;Anthony C Gordon.;Doreen Henry.;Nicholas Hudson.;Alexina J Mason.;Michelle Saull.;Chris Whitman.;J Duncan Young.;Kathryn M Rowan.;Paul R Mouncey.; .
来源: JAMA. 2020年323卷10期938-949页
Vasopressors are commonly administered to intensive care unit (ICU) patients to raise blood pressure. Balancing risks and benefits of vasopressors is a challenge, particularly in older patients.
9455. Diagnosis and Treatment of Parkinson Disease: A Review.
Parkinson disease is the most common form of parkinsonism, a group of neurological disorders with Parkinson disease-like movement problems such as rigidity, slowness, and tremor. More than 6 million individuals worldwide have Parkinson disease.
9458. Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial.
作者: Steven Y C Tong.;David C Lye.;Dafna Yahav.;Archana Sud.;J Owen Robinson.;Jane Nelson.;Sophia Archuleta.;Matthew A Roberts.;Alan Cass.;David L Paterson.;Hong Foo.;Mical Paul.;Stephen D Guy.;Adrian R Tramontana.;Genevieve B Walls.;Stephen McBride.;Narin Bak.;Niladri Ghosh.;Benjamin A Rogers.;Anna P Ralph.;Jane Davies.;Patricia E Ferguson.;Ravindra Dotel.;Genevieve L McKew.;Timothy J Gray.;Natasha E Holmes.;Simon Smith.;Morgyn S Warner.;Shirin Kalimuddin.;Barnaby E Young.;Naomi Runnegar.;David N Andresen.;Nicholas A Anagnostou.;Sandra A Johnson.;Mark D Chatfield.;Allen C Cheng.;Vance G Fowler.;Benjamin P Howden.;Niamh Meagher.;David J Price.;Sebastiaan J van Hal.;Matthew V N O'Sullivan.;Joshua S Davis.; .
来源: JAMA. 2020年323卷6期527-537页
Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with mortality of more than 20%. Combining standard therapy with a β-lactam antibiotic has been associated with reduced mortality, although adequately powered randomized clinical trials of this intervention have not been conducted.
9459. Effect of Incisional Negative Pressure Wound Therapy vs Standard Wound Dressing on Deep Surgical Site Infection After Surgery for Lower Limb Fractures Associated With Major Trauma: The WHIST Randomized Clinical Trial.
作者: Matthew L Costa.;Juul Achten.;Ruth Knight.;Julie Bruce.;Susan J Dutton.;Jason Madan.;Melina Dritsaki.;Nick Parsons.;Miguel Fernandez.;Richard Grant.;Jagdeep Nanchahal.; .
来源: JAMA. 2020年323卷6期519-526页
Following surgery to treat major trauma-related fractures, deep wound infection rates are high. It is not known if negative pressure wound therapy can reduce infection rates in this setting.
9460. Out-of-Network Bills for Privately Insured Patients Undergoing Elective Surgery With In-Network Primary Surgeons and Facilities.
作者: Karan R Chhabra.;Kyle H Sheetz.;Ushapoorna Nuliyalu.;Mihir S Dekhne.;Andrew M Ryan.;Justin B Dimick.
来源: JAMA. 2020年323卷6期538-547页
Privately insured patients who receive care from in-network physicians may receive unexpected out-of-network bills ("surprise bills") from out-of-network clinicians they did not choose. In elective surgery, this can occur if patients choose in-network surgeons and hospitals but receive out-of-network bills from other involved clinicians.
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