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841. Results of the Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-Controlled Study (SHARP): A Randomized Placebo-Controlled Double-Blind Repeated-Measures Crossover Phase IV Clinical Trial of the Effect of the Wake-Promoting Agent Solriamfetol on Cognitive Function in OSA With Excessive Daytime Sleepiness and Cognitive Impairment.
作者: Hans P A Van Dongen.;Eileen B Leary.;Christopher Drake.;Richard Bogan.;Judith Jaeger.;Russell Rosenberg.;Caroline Streicher.;Herriot Tabuteau.
来源: Chest. 2025年167卷3期863-875页
OSA causes episodes of fragmented sleep and intermittent hypoxia and leads to excessive daytime sleepiness (EDS). Deficits in cognitive function are a troublesome symptom in patients with OSA and EDS.
842. Quantitative CT Scan Analysis in Rheumatoid Arthritis-Related Interstitial Lung Disease.
作者: Stephen M Humphries.;Ayodeji Adegunsoye.;M Kristen Demoruelle.;Michelle Li Wei Kam.;Isabelle Amigues.;Tami J Bang.;Shawn D Teague.;David A Lynch.;Jonathan H Chung.;Mary E Strek.;Jeffrey J Swigris.;Joshua J Solomon.
来源: Chest. 2025年167卷5期1428-1439页
Quantitative CT imaging may be a useful predictor of outcome in rheumatoid arthritis-related interstitial lung disease (RA-ILD).
844. Effects of β-Blockers on the Outcomes in Patients With Pulmonary Arterial Hypertension Stratified by the Presence of Comorbid Conditions: A Multicenter Prospective Cohort Study: The Database of Pulmonary Hypertension in the Polish Population (BNP-PL).
作者: Marcin Waligóra.;Marcin Kurzyna.;Tatiana Mularek-Kubzdela.;Ilona Skoczylas.;Łukasz Chrzanowski.;Piotr Błaszczak.;Miłosz Jaguszewski.;Beata Kuśmierczyk.;Katarzyna Ptaszyńska.;Grzegorz Grześk.;Katarzyna Mizia-Stec.;Ewa Malinowska.;Małgorzata Peregud-Pogorzelska.;Ewa Lewicka.;Michał Tomaszewski.;Wojciech Jacheć.;Michał Florczyk.;Ewa Mroczek.;Zbigniew Gąsior.;Agnieszka Pawlak.;Katarzyna Betkier-Lipińska.;Piotr Pruszczyk.;Katarzyna Widejko.;Wiesława Zabłocka.;Grzegorz Kopeć.
来源: Chest. 2025年167卷4期1171-1181页
Current guidelines do not recommend β-blockers in pulmonary arterial hypertension (PAH) unless indicated by comorbidities. However, the evidence regarding the role of β-blockers in PAH is contradictory.
845. Sarcoidosis Treatment Patterns in the United States: 2016-2022.
作者: Ruchika Sangani.;Nicholas A Bosch.;Praveen Govender.;Brittany Scarpato.;Allan J Walkey.;Julia Newman.;Anica C Law.;Kari R Gillmeyer.;Divya A Shankar.
来源: Chest. 2025年167卷4期1099-1106页
There are limited US Food and Drug Administration-approved medications and real-world data on sarcoidosis treatment in the United States. Concordance of practice patterns with guideline recommendations have not been well characterized.
846. Comparison of Clinically Meaningful Improvements After Center-Based and Home-Based Telerehabilitation in People With COPD.
作者: Narelle S Cox.;Christine McDonald.;Angela T Burge.;Catherine J Hill.;Janet Bondarenko.;Anne E Holland.
来源: Chest. 2025年167卷4期1003-1011页
Response to pulmonary rehabilitation is not equal for all participants and may vary across health outcomes for any one individual. Alternative methods of pulmonary rehabilitation delivery, for example, telerehabilitation, may improve program access, but also could affect response to rehabilitation.
860. A 52-Year-Old Woman With Persistent Back Pain and Multiple Pulmonary Nodules.
作者: Moyan Sun.;Abijha Boban.;Schaza Rana.;Hossny Alaws.;Hisham F Qutob.
来源: Chest. 2024年166卷5期e157-e161页
A 52-year-old woman with a history of leiomyoma uteri and tobacco-use disorder in remission presented with 2 months of progressive back pain. Her pain was located between her shoulder blades and was described as constant with intermittent sharp, stabbing sensation. It was nonradiating and aggravated by inspiration. She denied fever, cough, shortness of breath, chest pain, or recent changes in weight or appetite. Two days prior, she was evaluated in the ED for similar symptoms and prescribed naproxen and cyclobenzaprine for suspected musculoskeletal pain. However, she received minimal relief, which prompted her visit. She underwent a total hysterectomy 13 years ago for benign uterine fibroid tumors. She had a 15-pack-year history but quit smoking 3 years ago. Family history was notable for colon and pancreatic cancer in her father and breast cancer in her maternal aunt.
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