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8241. Mechanistic Effects of Spironolactone on Cardiovascular and Renal Biomarkers in Heart Failure With Preserved Ejection Fraction: A TOPCAT Biorepository Study.
作者: Peder L Myhre.;Muthiah Vaduganathan.;Eileen O'Meara.;Brian L Claggett.;Simon de Denus.;Petr Jarolim.;Inder S Anand.;Bertram Pitt.;Jean L Rouleau.;Scott D Solomon.;Marc A Pfeffer.;Akshay S Desai.
来源: Circ Heart Fail. 2020年13卷1期e006638页
Spironolactone has been demonstrated to reduce heart failure (HF) hospitalization in patients with HF with preserved ejection fraction in the Americas region of the TOPCAT trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial). We assessed effects of 12 months of treatment with spironolactone on biomarkers reflecting myocardial stress, myocardial injury, renal function, and systemic inflammation.
8242. Long Noncoding RNA Ahit Protects Against Cardiac Hypertrophy Through SUZ12 (Suppressor of Zeste 12 Protein Homolog)-Mediated Downregulation of MEF2A (Myocyte Enhancer Factor 2A).
作者: Junyi Yu.;Yang Yang.;Zaicheng Xu.;Cong Lan.;Caiyu Chen.;Chuanwei Li.;Zhi Chen.;Cheng Yu.;Xuewei Xia.;Qiao Liao.;Pedro A Jose.;Chunyu Zeng.;Gengze Wu.
来源: Circ Heart Fail. 2020年13卷1期e006525页
Long noncoding RNA (lncRNA) can regulate various physiological and pathological processes through multiple molecular mechanisms in cis and in trans. However, the role of lncRNAs in cardiac hypertrophy is yet to be fully elucidated.
8246. Endovascular Versus Surgical Revascularization for Acute Limb Ischemia: A Propensity-Score Matched Analysis.
作者: Dhaval Kolte.;Kevin F Kennedy.;Mehdi H Shishehbor.;Shafiq T Mamdani.;Lars Stangenberg.;Omar N Hyder.;Peter Soukas.;Herbert D Aronow.
来源: Circ Cardiovasc Interv. 2020年13卷1期e008150页
The optimal revascularization strategy for acute limb ischemia (ALI) remains unclear, and contemporary comparative effectiveness data on endovascular versus surgical revascularization are lacking.
8247. Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction.
作者: Katharina Schimmel.;Mira Jung.;Ariana Foinquinos.;Gorka San José.;Javier Beaumont.;Katharina Bock.;Lea Grote-Levi.;Ke Xiao.;Christian Bär.;Angelika Pfanne.;Annette Just.;Karina Zimmer.;Soeun Ngoy.;Begoña López.;Susana Ravassa.;Sabine Samolovac.;Heike Janssen-Peters.;Janet Remke.;Kristian Scherf.;Seema Dangwal.;Maria-Teresa Piccoli.;Felix Kleemiss.;Fabian Philipp Kreutzer.;Franziska Kenneweg.;Julia Leonardy.;Lisa Hobuß.;Laura Santer.;Quoc-Tuan Do.;Robert Geffers.;Jan Hinrich Braesen.;Jessica Schmitz.;Christina Brandenberger.;Dominik N Müller.;Nicola Wilck.;Volkhard Kaever.;Heike Bähre.;Sandor Batkai.;Jan Fiedler.;Kevin M Alexander.;Bradley M Wertheim.;Sudeshna Fisch.;Ronglih Liao.;Javier Diez.;Arantxa González.;Thomas Thum.
来源: Circulation. 2020年141卷9期751-767页
Myocardial fibrosis is a hallmark of cardiac remodeling and functionally involved in heart failure development, a leading cause of deaths worldwide. Clinically, no therapeutic strategy is available that specifically attenuates maladaptive responses of cardiac fibroblasts, the effector cells of fibrosis in the heart. Therefore, our aim was to develop novel antifibrotic therapeutics based on naturally derived substance library screens for the treatment of cardiac fibrosis.
8249. Major Adverse Cardiovascular Events Associated With Postoperative Atrial Fibrillation After Noncardiac Surgery: A Systematic Review and Meta-Analysis.
作者: Ahmed AlTurki.;Mariam Marafi.;Riccardo Proietti.;Daniela Cardinale.;Robert Blackwell.;Paul Dorian.;Amal Bessissow.;Lucy Vieira.;Isabelle Greiss.;Vidal Essebag.;Jeff S Healey.;Thao Huynh.
来源: Circ Arrhythm Electrophysiol. 2020年13卷1期e007437页
Postoperative atrial fibrillation (POAF) is a frequent occurrence after noncardiac surgery. It remains unclear whether POAF is associated with an increased risk of major adverse events. We aimed to elucidate the risk of stroke, myocardial infarction, and death associated with POAF following noncardiac surgery by a meta-analysis of randomized controlled studies and observational studies.
8250. RADAR: A Multicenter Food and Drug Administration Investigational Device Exemption Clinical Trial of Persistent Atrial Fibrillation.
作者: Subbarao Choudry.;Moussa Mansour.;Sri Sundaram.;Duy T Nguyen.;Srinivas R Dukkipati.;William Whang.;Paul Kessman.;Vivek Y Reddy.
来源: Circ Arrhythm Electrophysiol. 2020年13卷1期e007825页
Pulmonary vein isolation is insufficient to treat all patients with persistent atrial fibrillation (AF), and effective adjunctive ablation strategies are needed. Ablation of AF drivers holds promise, but current technologies to identify drivers are limited by spatial resolution. In a single-arm, first-in-human, investigator-initiated Food and Drug Administration Investigational Device Exemption study, we used a novel system for real-time, high-resolution identification of AF drivers in persistent AF.
8251. Importance of Diastolic Function for the Prediction of Arrhythmic Death: A Prospective, Observer-Blinded, Long-Term Study.
作者: Thomas Pezawas.;Achim Leo Burger.;Thomas Binder.;André Diedrich.
来源: Circ Arrhythm Electrophysiol. 2020年13卷2期e007757页
Patients with ischemic or dilated cardiomyopathy and reduced left ventricular ejection fraction (LVEF) face a high risk for ventricular arrhythmias. Exact grading of diastolic function might improve risk stratification for arrhythmic death.
8252. An International Multicenter Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition.
作者: Jason D Roberts.;S Yukiko Asaki.;Andrea Mazzanti.;J Martijn Bos.;Izabela Tuleta.;Alison R Muir.;Lia Crotti.;Andrew D Krahn.;Valentina Kutyifa.;M Benjamin Shoemaker.;Christopher L Johnsrude.;Takeshi Aiba.;Luciana Marcondes.;Anwar Baban.;Sharmila Udupa.;Brynn Dechert.;Peter Fischbach.;Linda M Knight.;Eric Vittinghoff.;Deni Kukavica.;Birgit Stallmeyer.;John R Giudicessi.;Carla Spazzolini.;Keiko Shimamoto.;Rafik Tadros.;Julia Cadrin-Tourigny.;Henry J Duff.;Christopher S Simpson.;Thomas M Roston.;Yanushi D Wijeyeratne.;Imane El Hajjaji.;Maisoon D Yousif.;Lorne J Gula.;Peter Leong-Sit.;Nikhil Chavali.;Andrew P Landstrom.;Gregory M Marcus.;Sven Dittmann.;Arthur A M Wilde.;Elijah R Behr.;Jacob Tfelt-Hansen.;Melvin M Scheinman.;Marco V Perez.;Juan Pablo Kaski.;Robert M Gow.;Fabrizio Drago.;Peter F Aziz.;Dominic J Abrams.;Michael H Gollob.;Jonathan R Skinner.;Wataru Shimizu.;Elizabeth S Kaufman.;Dan M Roden.;Wojciech Zareba.;Peter J Schwartz.;Eric Schulze-Bahr.;Susan P Etheridge.;Silvia G Priori.;Michael J Ackerman.
来源: Circulation. 2020年141卷6期429-439页
Insight into type 5 long QT syndrome (LQT5) has been limited to case reports and small family series. Improved understanding of the clinical phenotype and genetic features associated with rare KCNE1 variants implicated in LQT5 was sought through an international multicenter collaboration.
8253. Dysfunctional High-Density Lipoproteins Are Associated With a Greater Incidence of Acute Coronary Syndrome in a Population at High Cardiovascular Risk: A Nested Case-Control Study.
作者: María Trinidad Soria-Florido.;Olga Castañer.;Camille Lassale.;Ramon Estruch.;Jordi Salas-Salvadó.;Miguel Ángel Martínez-González.;Dolores Corella.;Emilio Ros.;Fernando Arós.;Roberto Elosua.;José Lapetra.;Miquel Fiol.;Angel Alonso-Gómez.;Enrique Gómez-Gracia.;Lluís Serra-Majem.;Xavier Pintó.;Mònica Bulló.;Miguel Ruiz-Canela.;Jose V Sorlí.;Álvaro Hernáez.;Montserrat Fitó.
来源: Circulation. 2020年141卷6期444-453页
Studies have failed to establish a clear link between high-density lipoprotein (HDL) cholesterol and cardiovascular disease, leading to the hypothesis that the atheroprotective role of HDL lies in its biological activity rather than in its cholesterol content. However, to date, the association between HDL functional characteristics and acute coronary syndrome has not been investigated comprehensively.
8254. Time Trends in Cardiovascular Disease Mortality Across the BRICS: An Age-Period-Cohort Analysis of Key Nations With Emerging Economies Using the Global Burden of Disease Study 2017.
作者: Zhiyong Zou.;Karly Cini.;Bin Dong.;Yinghua Ma.;Jun Ma.;David P Burgner.;George C Patton.
来源: Circulation. 2020年141卷10期790-799页
Brazil, Russia, India, China, and South Africa (BRICS) are emerging economies making up almost half the global population. We analyzed trends in cardiovascular disease (CVD) mortality across the BRICS and associations with age, period, and birth cohort.
8255. Protein Biomarkers and Risk of Atrial Fibrillation: The FHS.
作者: Laila Staerk.;Sarah R Preis.;Honghuang Lin.;Steven A Lubitz.;Patrick T Ellinor.;Daniel Levy.;Emelia J Benjamin.;Ludovic Trinquart.
来源: Circ Arrhythm Electrophysiol. 2020年13卷2期e007607页
Identification of protein biomarkers associated with incident atrial fibrillation (AF) may improve the understanding of the pathophysiology, risk prediction, and development of new therapeutics for AF. We examined the associations between 85 protein biomarkers and incident AF.
8256. Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction.
作者: Gopalkrishna Sreejit.;Ahmed Abdel-Latif.;Baskaran Athmanathan.;Rahul Annabathula.;Ashish Dhyani.;Sunil K Noothi.;Gregory A Quaife-Ryan.;Annas Al-Sharea.;Gerard Pernes.;Dragana Dragoljevic.;Hind Lal.;Kate Schroder.;Beatriz Y Hanaoka.;Chander Raman.;Maria B Grant.;James E Hudson.;Susan S Smyth.;Enzo R Porrello.;Andrew J Murphy.;Prabhakara R Nagareddy.
来源: Circulation. 2020年141卷13期1080-1094页
Myocardial infarction (MI) triggers myelopoiesis, resulting in heightened production of neutrophils. However, the mechanisms that sustain their production and recruitment to the injured heart are unclear.
8257. Variation in Ultrasound Diagnostic Thresholds for Carotid Stenosis in the United States.
作者: Jesse A Columbo.;Robert M Zwolak.;Edward J Arous.;Philip P Goodney.;Michael P Lilly.;H Gilbert Welch.
来源: Circulation. 2020年141卷12期946-953页
Individuals with carotid stenosis enter surveillance or are considered for surgery on the basis of disease severity assessed by ultrasound. However, there is variation in the ultrasound diagnostic thresholds used to determine disease severity. Our objective was to describe this variation and its potential impact on patients.
8258. Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium.
作者: Matthew A Caporizzo.;Christina Yingxian Chen.;Ken Bedi.;Kenneth B Margulies.;Benjamin L Prosser.
来源: Circulation. 2020年141卷11期902-915页
Diastolic dysfunction is a prevalent and therapeutically intractable feature of heart failure (HF). Increasing ventricular compliance can improve diastolic performance, but the viscoelastic forces that resist diastolic filling and become elevated in human HF are poorly defined. Having recently identified posttranslationally detyrosinated microtubules as a source of viscoelasticity in cardiomyocytes, we sought to test whether microtubules contribute meaningful viscoelastic resistance to diastolic stretch in human myocardium.
8259. Orphan G Protein-Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling.
作者: Jorge Carvalho.;Ramesh Chennupati.;Rui Li.;Stefan Günther.;Harmandeep Kaur.;Wencai Zhao.;Sarah Tonack.;Michael Kurz.;Nadja Mößlein.;Moritz Bünemann.;Stefan Offermanns.;Nina Wettschureck.
来源: Circulation. 2020年141卷14期1168-1183页
G protein-coupled receptors are important regulators of contractility and differentiation in vascular smooth muscle cells (SMCs), but the specific function of SMC-expressed orphan G protein-coupled receptor class C group 5 member B (GPRC5B) is unclear.
8260. Survival After Intravenous Versus Intraosseous Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Shock-Refractory Cardiac Arrest.
作者: Mohamud R Daya.;Brian G Leroux.;Paul Dorian.;Thomas D Rea.;Craig D Newgard.;Laurie J Morrison.;Joshua R Lupton.;James J Menegazzi.;Joseph P Ornato.;George Sopko.;Jim Christenson.;Ahamed Idris.;Purav Mody.;Gary M Vilke.;Caroline Herdeman.;David Barbic.;Peter J Kudenchuk.; .
来源: Circulation. 2020年141卷3期188-198页
Antiarrhythmic drugs have not proven to significantly improve overall survival after out-of-hospital cardiac arrest from shock-refractory ventricular fibrillation/pulseless ventricular tachycardia. How this might be influenced by the route of drug administration is not known.
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