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8182. Immunogenicity of a Single Dose of SARS-CoV-2 Messenger RNA Vaccine in Solid Organ Transplant Recipients.
作者: Brian J Boyarsky.;William A Werbel.;Robin K Avery.;Aaron A R Tobian.;Allan B Massie.;Dorry L Segev.;Jacqueline M Garonzik-Wang.
来源: JAMA. 2021年325卷17期1784-1786页
This study quantifies antispike protein antibody responses to first-dose messenger RNA (mRNA) COVID-19 vaccines in solid organ transplant recipients to better understand the immunogenicity of the vaccines in immunocompromised individuals.
8186. Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19.
作者: Kathryn E Stephenson.;Mathieu Le Gars.;Jerald Sadoff.;Anne Marit de Groot.;Dirk Heerwegh.;Carla Truyers.;Caroline Atyeo.;Carolin Loos.;Abishek Chandrashekar.;Katherine McMahan.;Lisa H Tostanoski.;Jingyou Yu.;Makda S Gebre.;Catherine Jacob-Dolan.;Zhenfeng Li.;Shivani Patel.;Lauren Peter.;Jinyan Liu.;Erica N Borducchi.;Joseph P Nkolola.;Morgana Souza.;Chen Sabrina Tan.;Rebecca Zash.;Boris Julg.;Ruvandhi R Nathavitharana.;Roger L Shapiro.;Ahmed Abdul Azim.;Carolyn D Alonso.;Kate Jaegle.;Jessica L Ansel.;Diane G Kanjilal.;Caitlin J Guiney.;Connor Bradshaw.;Anna Tyler.;Tatenda Makoni.;Katherine E Yanosick.;Michael S Seaman.;Douglas A Lauffenburger.;Galit Alter.;Frank Struyf.;Macaya Douoguih.;Johan Van Hoof.;Hanneke Schuitemaker.;Dan H Barouch.
来源: JAMA. 2021年325卷15期1535-1544页
Control of the global COVID-19 pandemic will require the development and deployment of safe and effective vaccines.
8191. Screening for Lung Cancer: US Preventive Services Task Force Recommendation Statement.
作者: .;Alex H Krist.;Karina W Davidson.;Carol M Mangione.;Michael J Barry.;Michael Cabana.;Aaron B Caughey.;Esa M Davis.;Katrina E Donahue.;Chyke A Doubeni.;Martha Kubik.;C Seth Landefeld.;Li Li.;Gbenga Ogedegbe.;Douglas K Owens.;Lori Pbert.;Michael Silverstein.;James Stevermer.;Chien-Wen Tseng.;John B Wong.
来源: JAMA. 2021年325卷10期962-970页
Lung cancer is the second most common cancer and the leading cause of cancer death in the US. In 2020, an estimated 228 820 persons were diagnosed with lung cancer, and 135 720 persons died of the disease. The most important risk factor for lung cancer is smoking. Increasing age is also a risk factor for lung cancer. Lung cancer has a generally poor prognosis, with an overall 5-year survival rate of 20.5%. However, early-stage lung cancer has a better prognosis and is more amenable to treatment.
8192. Evaluation of the Benefits and Harms of Lung Cancer Screening With Low-Dose Computed Tomography: Modeling Study for the US Preventive Services Task Force.
作者: Rafael Meza.;Jihyoun Jeon.;Iakovos Toumazis.;Kevin Ten Haaf.;Pianpian Cao.;Mehrad Bastani.;Summer S Han.;Erik F Blom.;Daniel E Jonas.;Eric J Feuer.;Sylvia K Plevritis.;Harry J de Koning.;Chung Yin Kong.
来源: JAMA. 2021年325卷10期988-997页
The US Preventive Services Task Force (USPSTF) is updating its 2013 lung cancer screening guidelines, which recommend annual screening for adults aged 55 through 80 years who have a smoking history of at least 30 pack-years and currently smoke or have quit within the past 15 years.
8193. Screening for Lung Cancer With Low-Dose Computed Tomography: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
作者: Daniel E Jonas.;Daniel S Reuland.;Shivani M Reddy.;Max Nagle.;Stephen D Clark.;Rachel Palmieri Weber.;Chineme Enyioha.;Teri L Malo.;Alison T Brenner.;Charli Armstrong.;Manny Coker-Schwimmer.;Jennifer Cook Middleton.;Christiane Voisin.;Russell P Harris.
来源: JAMA. 2021年325卷10期971-987页
Lung cancer is the leading cause of cancer-related death in the US.
8196. Effect of Ventral vs Dorsal Spinal Surgery on Patient-Reported Physical Functioning in Patients With Cervical Spondylotic Myelopathy: A Randomized Clinical Trial.
作者: Zoher Ghogawala.;Norma Terrin.;Melissa R Dunbar.;Janis L Breeze.;Karen M Freund.;Adam S Kanter.;Praveen V Mummaneni.;Erica F Bisson.;Fred G Barker.;J Sanford Schwartz.;James S Harrop.;Subu N Magge.;Robert F Heary.;Michael G Fehlings.;Todd J Albert.;Paul M Arnold.;K Daniel Riew.;Michael P Steinmetz.;Marjorie C Wang.;Robert G Whitmore.;John G Heller.;Edward C Benzel.
来源: JAMA. 2021年325卷10期942-951页
Cervical spondylotic myelopathy is the most common cause of spinal cord dysfunction worldwide. It remains unknown whether a ventral or dorsal surgical approach provides the best results.
8197. Prevalence of Central Nervous System-Active Polypharmacy Among Older Adults With Dementia in the US.
作者: Donovan T Maust.;Julie Strominger.;H Myra Kim.;Kenneth M Langa.;Julie P W Bynum.;Chiang-Hua Chang.;Helen C Kales.;Kara Zivin.;Erica Solway.;Steven C Marcus.
来源: JAMA. 2021年325卷10期952-961页
Community-dwelling older adults with dementia have a high prevalence of psychotropic and opioid use. In these patients, central nervous system (CNS)-active polypharmacy may increase the risk for impaired cognition, fall-related injury, and death.
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