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7902. Top down or bottom up? An observational investigation of improvement in fibromyalgia symptoms following hip and knee replacement.
作者: Andrew Schrepf.;Stephanie Moser.;Steven E Harte.;Neil Basu.;Chelsea Kaplan.;Ellen Kolarik.;Alexander Tsodikov.;Chad M Brummett.;Daniel J Clauw.
来源: Rheumatology (Oxford). 2020年59卷3期594-602页
Many patients with osteoarthritis have comorbid symptoms of FM, but it is unknown how these symptoms respond to surgical procedures that address nociceptive input in the periphery, such as total joint replacement. Here we explore differences in clinical characteristics between patients whose FM symptoms do and do not improve following total hip or knee replacement.
7903. Sudanese and Swedish patients with systemic lupus erythematosus: immunological and clinical comparisons.
作者: Sahwa Elbagir.;Amir I Elshafie.;Elnour M Elagib.;NasrEldeen A Mohammed.;Mawahib I E Aledrissy.;Azita Sohrabian.;Musa A M Nur.;Elisabet Svenungsson.;Iva Gunnarsson.;Johan Rönnelid.
来源: Rheumatology (Oxford). 2020年59卷5期968-978页
SLE is known to have an aggressive phenotype in black populations, but data from African cohorts are largely lacking. We therefore compared immunological and clinical profiles between Sudanese and Swedish patients using similar tools.
7904. Improvement of MEFV gene variants classification to aid treatment decision making in familial Mediterranean fever.
作者: Matteo Accetturo.;Angela Maria D'Uggento.;Piero Portincasa.;Alessandro Stella.
来源: Rheumatology (Oxford). 2020年59卷4期754-761页
FMF is an inherited autoinflammatory syndrome caused by mutations in the MEFV gene. MEFV variants are still largely classified as acvariant of uncertain significance, or with unresolved classification, posing significant challenges in FMF diagnosis. Rare Exome Variant Ensemble Learner (REVEL) is a recently developed variant metapredictor tool. To reduce the number of MEFV variants with ambiguous classification, we extracted REVEL scores for all missense variants present in the INFEVERS database, and analysed its correlation with expert-based classification and localization in the MEFV-encoded pyrin functional domains.
7906. Human osteoarthritic synovial fluid increases excitability of mouse dorsal root ganglion sensory neurons: an in-vitro translational model to study arthritic pain.
作者: Sampurna Chakrabarti.;Deepak R Jadon.;David C Bulmer.;Ewan St John Smith.
来源: Rheumatology (Oxford). 2020年59卷3期662-667页
Knee OA is a leading global cause of morbidity. This study investigates the effects of knee SF from patients with OA on the activity of dorsal root ganglion sensory neurons that innervate the knee (knee neurons) as a novel translational model of disease-mediated nociception in human OA.
7907. Enthesopathy and involvement of synovio-entheseal complex in systemic sclerosis: an ultrasound pilot study.
作者: Riccardo Terenzi.;Rositsa Karalilova.;Gemma Lepri.;Cosimo Bruni.;Silvia Bellando-Randone.;Mirko Manetti.;Eloisa Romano.;Daniela Melchiorre.;Jelena Blagojevic.;Yukai Wang.;Kamal Solanki.;Alberto Moggi-Pignone.;Zguro Batalov.;Serena Guiducci.;Anastas Batalov.;Marco Matucci-Cerinic.
来源: Rheumatology (Oxford). 2020年59卷3期580-585页
SSc is a chronic autoimmune disease characterized by inflammation of the skin and multiple internal organs. Articular involvement is one of the main features of SSc, and typical hallmarks of SpA have been found in SSc patients. The aim of the present study was to estimate the prevalence of entheseal and synovio-entheseal complex (SEC) alterations in a cohort of SSc patients.
7908. Predictive factors for sustained remission with stratification by myositis-specific autoantibodies in adult polymyositis/dermatomyositis.
作者: Eri Watanabe.;Takahisa Gono.;Masataka Kuwana.;Chihiro Terai.
来源: Rheumatology (Oxford). 2020年59卷3期586-593页
The aim of this study was to clarify predictive factors for sustained remission in adult patients with PM/DM, particularly focusing on stratification by myositis-specific autoantibodies (MSAs).
7909. Next generation sequencing panel in undifferentiated autoinflammatory diseases identifies patients with colchicine-responder recurrent fevers.
作者: Riccardo Papa.;Marta Rusmini.;Stefano Volpi.;Roberta Caorsi.;Paolo Picco.;Alice Grossi.;Francesco Caroli.;Francesca Bovis.;Valeria Musso.;Laura Obici.;Cinzia Castana.;Angelo Ravelli.;Marielle E Van Gijn.;Isabella Ceccherini.;Marco Gattorno.
来源: Rheumatology (Oxford). 2020年59卷2期458页 7910. Nurse-led care is preferred over GP-led care of gout and improves gout outcomes: results of Nottingham Gout Treatment Trial follow-up study.
作者: Amy Fuller.;Wendy Jenkins.;Michael Doherty.;Abhishek Abhishek.
来源: Rheumatology (Oxford). 2020年59卷3期575-579页
To explore patient satisfaction, gout knowledge, medication adherence and flares among participants receiving nurse-led or general practitioner (GP)-led care of gout in the Nottingham Gout Treatment Trial phase-II (NGTT-II).
7911. Experience with tofacitinib in Canada: patient characteristics and treatment patterns in rheumatoid arthritis over 3 years.
作者: Janet Pope.;Louis Bessette.;Niall Jones.;Lara Fallon.;John Woolcott.;David Gruben.;Michael Crooks.;David Gold.;Boulos Haraoui.
来源: Rheumatology (Oxford). 2020年59卷3期568-574页
To describe characteristics, treatment patterns and persistence in patients with RA treated with tofacitinib, an oral Janus kinase inhibitor, in Canadian clinical practice between 1 June 2014 and 31 May 2017.
7912. British kindred with dominant FMF associated with high incidence of AA amyloidosis caused by novel MEFV variant, and a review of the literature.
作者: Dorota M Rowczenio.;Taryn Youngstein.;Hadija Trojer.;Ebun Omoyinmi.;Anna Baginska.;Paul Brogan.;Charalampia Papadopoulou.;Tamer Rezk.;Philip N Hawkins.;Helen J Lachmann.
来源: Rheumatology (Oxford). 2020年59卷3期554-558页
Hereditary systemic autoinflammatory diseases are rare genetic disorders, which if untreated, can be complicated by AA amyloidosis leading to renal failure and premature death. Our objective was to find a genetic cause in a British family with a dominantly inherited autoinflammatory disease complicated by AA amyloidosis.
7913. Clinical characteristics of cancer-associated myositis complicated by interstitial lung disease: a large-scale multicentre cohort study.
作者: Yuko Kaneko.;Takahiro Nunokawa.;Yoshinori Taniguchi.;Yukie Yamaguchi.;Takahisa Gono.;Kenichi Masui.;Atsushi Kawakami.;Yasushi Kawaguchi.;Shinji Sato.;Masataka Kuwana.; .
来源: Rheumatology (Oxford). 2020年59卷1期112-119页
To clarify the incidence, risk factors, and impact of malignancy in patients with PM/DM-associated interstitial lung disease (ILD).
7915. Characteristics and management of giant cell arteritis in France: a study based on national health insurance claims data.
作者: Alfred Mahr.;Manon Belhassen.;Marc Paccalin.;Valérie Devauchelle-Pensec.;Maeva Nolin.;Sophie Gandon.;Isabelle Idier.;Eric Hachulla.
来源: Rheumatology (Oxford). 2020年59卷1期120-128页
Few data are available on the epidemiology and management of GCA in real life. We aimed to address this situation by using health insurance claims data for France.
7916. Flares in rheumatoid arthritis: do patient-reported swollen and tender joints match clinical and ultrasonography findings?
作者: Dorota Kuettel.;Lene Terslev.;Ulrich Weber.;Mikkel Østergaard.;Jette Primdahl.;Randi Petersen.;Mads Ammitzbøll-Danielsen.;Sören Möller.;Kim Hørslev-Petersen.
来源: Rheumatology (Oxford). 2020年59卷1期129-136页
To investigate how patient-reported flares in RA are related to clinical joint examination and inflammation detected by US.
7918. Aberrant MUC1 accumulation in salivary glands of Sjögren's syndrome patients is reversed by TUDCA in vitro.
作者: Isabel Castro.;Nicolás Albornoz.;Sergio Aguilera.;María-José Barrera.;Sergio González.;Matilde Núñez.;Patricia Carvajal.;Daniela Jara.;Carolina Lagos.;Claudio Molina.;Ulises Urzúa.;Marcela A Hermoso.;María-Julieta González.
来源: Rheumatology (Oxford). 2020年59卷4期742-753页
Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration and protection of the oral mucosa. The aim of this study was to evaluate if cytokines induce aberrant mucin expression and whether tauroursodeoxycholic acid (TUDCA) is able to counteract such an anomaly.
7919. IL-16 expression is increased in the skin and sera of patients with systemic sclerosis.
作者: Kazuo Kawabata.;Takamitsu Makino.;Katsunari Makino.;Ikko Kajihara.;Satoshi Fukushima.;Hironobu Ihn.
来源: Rheumatology (Oxford). 2020年59卷3期519-523页
SSc is an autoimmune disease with chronic and persistent inflammation in its pathogenesis. To examine the expression pattern of IL-16 in SSc lesions, the serum concentration of IL-16 in SSc patients and the relationship between serum IL-16 levels and the clinical symptoms of SSc were investigated.
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