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7882. Molecular Signatures of Beneficial Class Effects of Statins on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
作者: Lei Tian.;Angelos Oikonomopoulos.;Chun Liu.;Tomoya Kitani.;Rajani Shrestha.;Christopher L Chen.;Sang-Ging Ong.;Mark Smeets.;Ioannis Karakikes.;Nazish Sayed.;Joseph C Wu.
来源: Circulation. 2020年141卷14期1208-1210页 7885. Letter by Kim et al Regarding Article, "Clinically Significant Bleeding With Ticagrelor Versus Clopidogrel in Korean Patients With Acute Coronary Syndromes Intended for Invasive Management: A Randomized Clinical Trial".7886. Value of Hemodynamic Monitoring in Patients With Cardiogenic Shock Undergoing Mechanical Circulatory Support.
作者: Abhinav Saxena.;A Reshad Garan.;Navin K Kapur.;William W O'Neill.;JoAnn Lindenfeld.;Sean P Pinney.;Nir Uriel.;Daniel Burkhoff.;Morton Kern.
来源: Circulation. 2020年141卷14期1184-1197页
The recent widespread availability and use of mechanical circulatory support is transforming the management and outcomes of cardiogenic shock (CS). Clinical decision-making regarding the optimization of therapies for patients with CS can be guided effectively by hemodynamic monitoring with a pulmonary artery catheter (PAC). Because several studies regarding the benefit of PACs are ambiguous, the use of PACs is variable among clinicians treating patients with CS. More notable is that PAC use has not been studied as part of a randomized, controlled trial in patients with CS with or without mechanical circulatory support. Standardized approaches to hemodynamic monitoring in these patients can improve decision-making and outcomes. In this review, we summarize the hemodynamics of CS and mechanical circulatory support with PAC-derived measurements, and provide a compelling rationale for the use of PAC monitoring in patients with CS receiving mechanical circulatory support.
7889. Significance of Aortopulmonary Collaterals in a Single-Ventricle Patient Supported With a HeartMate 3.
作者: Monica Smith.;Howaida El-Said.;Victor Pretorius.;Maggie Mendenhall.;Tracy Thomas.;Ryan R Reeves.;Jorge Silva Enciso.;Laith Alshawabkeh.;John Nigro.;Eric D Adler.;Marcus A Urey.
来源: Circ Heart Fail. 2020年13卷4期e006473页 7890. Representativeness of the PIONEER-HF Clinical Trial Population in Patients Hospitalized With Heart Failure and Reduced Ejection Fraction.
作者: Marat Fudim.;Sabina Sayeed.;Haolin Xu.;Roland A Matsouaka.;Paul A Heidenreich.;Eric J Velazquez.;Clyde W Yancy.;Gregg C Fonarow.;Adrian F Hernandez.;Adam D DeVore.
来源: Circ Heart Fail. 2020年13卷4期e006645页
In PIONEER-HF (Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-pro BNP in Patients Stabilized From an Acute Heart Failure Episode), the in-hospital initiation of sacubitril/valsartan in patients hospitalized for acute decompensated heart failure (ADHF) was well-tolerated and led to improved outcomes. We aim to determine the representativeness of the PIONEER-HF trial among patients hospitalized for ADHF using real-world data.
7891. The Variety of Cardiovascular Presentations of COVID-19.
作者: Justin A Fried.;Kumudha Ramasubbu.;Reema Bhatt.;Veli K Topkara.;Kevin J Clerkin.;Evelyn Horn.;LeRoy Rabbani.;Daniel Brodie.;Sneha S Jain.;Ajay J Kirtane.;Amirali Masoumi.;Koji Takeda.;Deepa Kumaraiah.;Daniel Burkhoff.;Martin Leon.;Allan Schwartz.;Nir Uriel.;Gabriel Sayer.
来源: Circulation. 2020年141卷23期1930-1936页 7892. Letter by Pilz et al Regarding Article, "Impact of Coronavirus Disease 2019 (COVID-19) Outbreak on ST-Segment-Elevation Myocardial Infarction Care in Hong Kong, China".
作者: Stefan Pilz.;Verena Theiler-Schwetz.;Christian Trummer.
来源: Circ Cardiovasc Qual Outcomes. 2020年13卷5期e006734页 7894. Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure.
作者: Julio A Chirinos.;Lei Zhao.;Yi Jia.;Cecilia Frej.;Luigi Adamo.;Douglas Mann.;Swapnil V Shewale.;John S Millar.;Daniel J Rader.;Benjamin French.;Jeff Brandimarto.;Kenneth B Margulies.;John S Parks.;Zhaoqing Wang.;Dietmar A Seiffert.;James Fang.;Nancy Sweitzer.;Christina Chistoffersen.;Björn Dahlbäck.;Bruce D Car.;David A Gordon.;Thomas P Cappola.;Ali Javaheri.
来源: Circulation. 2020年141卷18期1463-1476页
Apo (apolipoprotein) M mediates the physical interaction between high-density lipoprotein (HDL) particles and sphingosine-1-phosphate (S1P). Apo M exerts anti-inflammatory and cardioprotective effects in animal models.
7895. Practice Patterns Surrounding Pregnancy After Heart Transplantation.
作者: Ersilia M DeFilippis.;Jennifer Haythe.;Maryjane A Farr.;Jon Kobashigawa.;Michelle M Kittleson.
来源: Circ Heart Fail. 2020年13卷4期e006811页
Pregnancy after heart transplantation (HT) is a concern for many female recipients. The International Society for Heart and Lung Transplantation has guidelines regarding reproductive health, but limited data exist regarding providers' attitudes and practices surrounding pregnancy post-HT.
7896. Coronary Artery Calcium for Personalized Allocation of Aspirin in Primary Prevention of Cardiovascular Disease in 2019: The MESA Study (Multi-Ethnic Study of Atherosclerosis).
作者: Miguel Cainzos-Achirica.;Michael D Miedema.;John W McEvoy.;Mahmoud Al Rifai.;Philip Greenland.;Zeina Dardari.;Matthew Budoff.;Roger S Blumenthal.;Joseph Yeboah.;Daniel A Duprez.;Martin Bødtker Mortensen.;Omar Dzaye.;Jonathan Hong.;Khurram Nasir.;Michael J Blaha.
来源: Circulation. 2020年141卷19期1541-1553页
Recent American College of Cardiology/American Heart Association Primary Prevention Guidelines recommended considering low-dose aspirin therapy only among adults 40 to 70 years of age who are at higher atherosclerotic cardiovascular disease (ASCVD) risk but not at high risk of bleeding. However, it remains unclear how these patients are best identified. The present study aimed to assess the value of coronary artery calcium (CAC) for guiding aspirin allocation for primary prevention by using 2019 aspirin meta-analysis data on cardiovascular disease relative risk reduction and bleeding risk.
7897. Is the Affordable Care Act Medicaid Expansion Linked to Change in Rate of Ventricular Assist Device Implantation for Blacks and Whites?
作者: Khadijah K Breathett.;Shannon M Knapp.;Patrick Wightman.;Archita Desai.;Sula Mazimba.;Elizabeth Calhoun.;Nancy K Sweitzer.
来源: Circ Heart Fail. 2020年13卷4期e006544页
The Affordable Care Act (ACA) has been associated with increased heart transplant listings among blacks, who are disproportionately uninsured. It is unclear whether the ACA is also associated with increased ventricular assist device implantation in blacks.
7899. Letter by Priya et al Regarding Article, "Over-Testing for Suspected Pulmonary Embolism in American Emergency Departments: The Continuing Epidemic".
作者: Sarv Priya.;Tanya Aggarwal.;Prashant Nagpal.
来源: Circ Cardiovasc Qual Outcomes. 2020年13卷4期e006560页 7900. Guidance for Cardiac Electrophysiology During the COVID-19 Pandemic from the Heart Rhythm Society COVID-19 Task Force; Electrophysiology Section of the American College of Cardiology; and the Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, American Heart Association.
作者: Dhanunjaya R Lakkireddy.;Mina K Chung.;Rakesh Gopinathannair.;Kristen K Patton.;Ty J Gluckman.;Mohit Turagam.;Jim Cheung.;Parin Patel.;Juan Sotomonte.;Rachel Lampert.;Janet K Han.;Bharath Rajagopalan.;Lee Eckhardt.;Jose Joglar.;Kristin Sandau.;Brian Olshansky.;Elaine Wan.;Peter A Noseworthy.;Miguel Leal.;Elizabeth Kaufman.;Alejandra Gutierrez.;Joseph E Marine.;Paul J Wang.;Andrea M Russo.
来源: Circulation. 2020年141卷21期e823-e831页
Coronavirus disease 2019 (COVID-19) is a global pandemic that is wreaking havoc on the health and economy of much of human civilization. Electrophysiologists have been impacted personally and professionally by this global catastrophe. In this joint article from representatives of the Heart Rhythm Society, the American College of Cardiology, and the American Heart Association, we identify the potential risks of exposure to patients, allied healthcare staff, industry representatives, and hospital administrators. We also describe the impact of COVID-19 on cardiac arrhythmias and methods of triage based on acuity and patient comorbidities. We provide guidance for managing invasive and noninvasive electrophysiology procedures, clinic visits, and cardiac device interrogations. In addition, we discuss resource conservation and the role of telemedicine in remote patient care along with management strategies for affected patients.
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