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7761. Association of Initial Treatment With Antibiotics vs Surgery With Treatment Success and Disability in Subgroups of Children With Uncomplicated Appendicitis.
作者: Peter C Minneci.;Erinn M Hade.;Gregory A Metzger.;Jacqueline M Saito.;Grace Z Mak.;Katherine J Deans.; .
来源: JAMA. 2021年325卷24期2502-2504页
This study investigates differences in 1-year outcomes by clinical and socioeconomic factors among US children with uncomplicated appendicitis who were treated with antibiotics vs surgery.
7772. Transcatheter Treatment of Valvular Heart Disease: A Review.
More than 40 million people are living with either mitral or aortic valve disease worldwide, and more than 180 000 heart valve replacement surgeries are performed each year in the US. Transcatheter valve repair has emerged as an important therapeutic option for patients who are candidates for heart valve replacement.
7775. Guidelines for Reporting Trial Protocols and Completed Trials Modified Due to the COVID-19 Pandemic and Other Extenuating Circumstances: The CONSERVE 2021 Statement.
作者: Aaron M Orkin.;Peter J Gill.;Davina Ghersi.;Lisa Campbell.;Jeremy Sugarman.;Richard Emsley.;Philippe Gabriel Steg.;Charles Weijer.;John Simes.;Tanja Rombey.;Hywel C Williams.;Janet Wittes.;David Moher.;Dawn P Richards.;Yvette Kasamon.;Kenneth Getz.;Sally Hopewell.;Kay Dickersin.;Taixiang Wu.;Ana Patricia Ayala.;Kenneth F Schulz.;Sabine Calleja.;Isabelle Boutron.;Joseph S Ross.;Robert M Golub.;Karim M Khan.;Cindy Mulrow.;Nandi Siegfried.;Joerg Heber.;Naomi Lee.;Pamela Reed Kearney.;Rhoda K Wanyenze.;Asbjørn Hróbjartsson.;Rebecca Williams.;Nita Bhandari.;Peter Jüni.;An-Wen Chan.; .
来源: JAMA. 2021年326卷3期257-265页
Extenuating circumstances can trigger unplanned changes to randomized trials and introduce methodological, ethical, feasibility, and analytical challenges that can potentially compromise the validity of findings. Numerous randomized trials have required changes in response to the COVID-19 pandemic, but guidance for reporting such modifications is incomplete.
7776. Sperm Parameters Before and After COVID-19 mRNA Vaccination.
作者: Daniel C Gonzalez.;Daniel E Nassau.;Kajal Khodamoradi.;Emad Ibrahim.;Ruben Blachman-Braun.;Jesse Ory.;Ranjith Ramasamy.
来源: JAMA. 2021年326卷3期273-274页
To address vaccine hesitancy based on concerns about fertility, this study assesses sperm parameters before and after mRNA vaccine administration.
7779. Association Between Hospital Voluntary Participation, Mandatory Participation, or Nonparticipation in Bundled Payments and Medicare Episodic Spending for Hip and Knee Replacements.
作者: Joshua M Liao.;Atul Gupta.;Yueming Zhao.;Jingsan Zhu.;Joseph Martinez.;Deborah S Cousins.;Amol S Navathe.
来源: JAMA. 2021年326卷5期438-40页
This study uses Medicare claims data to compare spending for hip and joint replacements among hospitals with voluntary vs mandatory participation vs nonparticipation in the Medicare Bundled Payments for Care Improvement program between 2011 and 2017.
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