7647. Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.
作者: Christopher G Hughes.;Patrick T Mailloux.;John W Devlin.;Joshua T Swan.;Robert D Sanders.;Antonio Anzueto.;James C Jackson.;Aimee S Hoskins.;Brenda T Pun.;Onur M Orun.;Rameela Raman.;Joanna L Stollings.;Amy L Kiehl.;Matthew S Duprey.;Lan N Bui.;Hollis R O'Neal.;Allison Snyder.;Michael A Gropper.;Kalpalatha K Guntupalli.;Gregg J Stashenko.;Mayur B Patel.;Nathan E Brummel.;Timothy D Girard.;Robert S Dittus.;Gordon R Bernard.;E Wesley Ely.;Pratik P Pandharipande.; .
来源: N Engl J Med. 2021年384卷15期1424-1436页
Guidelines currently recommend targeting light sedation with dexmedetomidine or propofol for adults receiving mechanical ventilation. Differences exist between these sedatives in arousability, immunity, and inflammation. Whether they affect outcomes differentially in mechanically ventilated adults with sepsis undergoing light sedation is unknown.
7648. Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19.
作者: Michael J Joyner.;Rickey E Carter.;Jonathon W Senefeld.;Stephen A Klassen.;John R Mills.;Patrick W Johnson.;Elitza S Theel.;Chad C Wiggins.;Katelyn A Bruno.;Allan M Klompas.;Elizabeth R Lesser.;Katie L Kunze.;Matthew A Sexton.;Juan C Diaz Soto.;Sarah E Baker.;John R A Shepherd.;Noud van Helmond.;Nicole C Verdun.;Peter Marks.;Camille M van Buskirk.;Jeffrey L Winters.;James R Stubbs.;Robert F Rea.;David O Hodge.;Vitaly Herasevich.;Emily R Whelan.;Andrew J Clayburn.;Kathryn F Larson.;Juan G Ripoll.;Kylie J Andersen.;Matthew R Buras.;Matthew N P Vogt.;Joshua J Dennis.;Riley J Regimbal.;Philippe R Bauer.;Janis E Blair.;Nigel S Paneth.;DeLisa Fairweather.;R Scott Wright.;Arturo Casadevall.
来源: N Engl J Med. 2021年384卷11期1015-1027页
Convalescent plasma has been widely used to treat coronavirus disease 2019 (Covid-19) under the presumption that such plasma contains potentially therapeutic antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can be passively transferred to the plasma recipient. Whether convalescent plasma with high antibody levels rather than low antibody levels is associated with a lower risk of death is unknown.
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