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7604. Role of Spirituality on the Association Between Depression and Quality of Life in Stroke Survivor-Care Partner Dyads.
作者: Gianluca Pucciarelli.;Ercole Vellone.;Tatiana Bolgeo.;Silvio Simeone.;Rosaria Alvaro.;Christopher S Lee.;Karen S Lyons.
来源: Circ Cardiovasc Qual Outcomes. 2020年13卷6期e006129页
Little is known about the protective effect of spirituality on the association between known risk factors such as depression and quality of life (QOL) in stroke survivor-care partner dyads. Therefore, the aim of this study was to evaluate the moderating role of spirituality on the association between depressive symptomatology and QOL in stroke survivor-care partner dyads.
7605. Cardiovascular Toxicities Associated With Hydroxychloroquine and Azithromycin: An Analysis of the World Health Organization Pharmacovigilance Database.
作者: Lee S Nguyen.;Charles Dolladille.;Milou-Daniel Drici.;Charlotte Fenioux.;Joachim Alexandre.;Jean-Paul Mira.;Javid J Moslehi.;Dan M Roden.;Christian Funck-Brentano.;Joe-Elie Salem.
来源: Circulation. 2020年142卷3期303-305页 7607. Environment-Sensing Aryl Hydrocarbon Receptor Inhibits the Chondrogenic Fate of Modulated Smooth Muscle Cells in Atherosclerotic Lesions.
作者: Juyong Brian Kim.;Quanyi Zhao.;Trieu Nguyen.;Milos Pjanic.;Paul Cheng.;Robert Wirka.;Stanislao Travisano.;Manabu Nagao.;Ramendra Kundu.;Thomas Quertermous.
来源: Circulation. 2020年142卷6期575-590页
Smooth muscle cells (SMC) play a critical role in atherosclerosis. The Aryl hydrocarbon receptor (AHR) is an environment-sensing transcription factor that contributes to vascular development, and has been implicated in coronary artery disease risk. We hypothesized that AHR can affect atherosclerosis by regulating phenotypic modulation of SMC.
7608. Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models.
作者: Li Yang.;Bing Han.;Zhiting Zhang.;Shuguo Wang.;Ying Bai.;Yuan Zhang.;Ying Tang.;Lingli Du.;Ling Xu.;Fangfang Wu.;Lei Zuo.;Xufeng Chen.;Yu Lin.;Kezhong Liu.;Qingqing Ye.;Biling Chen.;Bin Li.;Tianci Tang.;Yu Wang.;Ling Shen.;Guangtian Wang.;Minzi Ju.;Mengqin Yuan.;Wei Jiang.;John H Zhang.;Gang Hu.;Jianhong Wang.;Honghong Yao.
来源: Circulation. 2020年142卷6期556-574页
Stroke is a leading cause of adult disability that can severely compromise the quality of life of patients, yet no effective medication currently exists to accelerate rehabilitation. A variety of circular RNA (circRNA) molecules are known to function in ischemic brain injury. Lentivirus-based expression systems have been widely used in basic studies of circRNAs, but safety issues with such delivery systems have limited exploration of the potential therapeutic roles for circRNAs.
7609. Cardiac Energetics in Patients With Aortic Stenosis and Preserved Versus Reduced Ejection Fraction.
作者: Mark A Peterzan.;William T Clarke.;Craig A Lygate.;Hannah A Lake.;Justin Y C Lau.;Jack J Miller.;Errin Johnson.;Jennifer J Rayner.;Moritz J Hundertmark.;Rana Sayeed.;Mario Petrou.;George Krasopoulos.;Vivek Srivastava.;Stefan Neubauer.;Christopher T Rodgers.;Oliver J Rider.
来源: Circulation. 2020年141卷24期1971-1985页
Why some but not all patients with severe aortic stenosis (SevAS) develop otherwise unexplained reduced systolic function is unclear. We investigate the hypothesis that reduced creatine kinase (CK) capacity and flux is associated with this transition.
7611. Identification of Wild-Type Transthyretin Cardiac Amyloidosis by Quantifying Myocardial Extracellular Volume Using Cardiac Computed Tomography in Atrial Arrhythmias.
作者: Seitaro Oda.;Masafumi Kidoh.;Seiji Takashio.;Masato Nishi.;Hisanori Kanazawa.;Yasunori Nagayama.;Takeshi Nakaura.;Kenichi Tsujita.;Osamu Ikeda.
来源: Circ Cardiovasc Imaging. 2020年13卷6期e010261页 7612. Use of Chloroquine and Hydroxychloroquine in COVID-19 and Cardiovascular Implications: Understanding Safety Discrepancies to Improve Interpretation and Design of Clinical Trials.
作者: Ohad Oren.;Eric H Yang.;Ty J Gluckman.;Erin D Michos.;Roger S Blumenthal.;Bernard J Gersh.
来源: Circ Arrhythm Electrophysiol. 2020年13卷6期e008688页 7613. The COMPASS Trial: Net Clinical Benefit of Low-Dose Rivaroxaban Plus Aspirin as Compared With Aspirin in Patients With Chronic Vascular Disease.
作者: Jan Steffel.;John W Eikelboom.;Sonia S Anand.;Olga Shestakovska.;Salim Yusuf.;Keith A A Fox.
来源: Circulation. 2020年142卷1期40-48页
Rivaroxaban 2.5 mg twice daily plus acetylsalicylic acid (aspirin; ASA) 100 mg reduced the risk of cardiovascular events as compared with ASA monotherapy in the COMPASS trial (Cardiovascular Outcomes for People Using Anticoagulation Strategies) but increased the risk of major bleedings. Analysis of net clinical benefit (NCB) is of key clinical relevance and represents an integrated measure of overall patient outcome.
7614. Use of Administrative Claims to Assess Outcomes and Treatment Effect in Randomized Clinical Trials for Transcatheter Aortic Valve Replacement: Findings From the EXTEND Study.
作者: Jordan B Strom.;Kamil F Faridi.;Neel M Butala.;Yuansong Zhao.;Hector Tamez.;Linda R Valsdottir.;J Matthew Brennan.;Changyu Shen.;Jeffrey J Popma.;Dhruv S Kazi.;Robert W Yeh.
来源: Circulation. 2020年142卷3期203-213页
Whether passively collected data can substitute for adjudicated outcomes to reproduce the magnitude and direction of treatment effect observed in cardiovascular clinical trials is not well known.
7615. Real-Time Closed-Loop Suppression of Repolarization Alternans Reduces Arrhythmia Susceptibility In Vivo.
作者: Faisal M Merchant.;Omid Sayadi.;Kwanghyun Sohn.;Eric H Weiss.;Dheeraj Puppala.;Rajiv Doddamani.;Jagmeet P Singh.;E Kevin Heist.;Chris Owen.;Kanchan Kulkarni.;Antonis A Armoundas.
来源: Circ Arrhythm Electrophysiol. 2020年13卷6期e008186页
Repolarization alternans (RA) has been implicated in the pathogenesis of ventricular arrhythmias and sudden cardiac death.
7616. Cardiac Arrhythmias in COVID-19 Infection.
作者: Stephanie M Kochav.;Ellie Coromilas.;Ani Nalbandian.;Lauren S Ranard.;Aakriti Gupta.;Mina K Chung.;Rakesh Gopinathannair.;Angelo B Biviano.;Hasan Garan.;Elaine Y Wan.
来源: Circ Arrhythm Electrophysiol. 2020年13卷6期e008719页 7617. Randomized Comparison of the Polymer-Free Biolimus-Coated BioFreedom Stent With the Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting Orsiro Stent in an All-Comers Population Treated With Percutaneous Coronary Intervention: The SORT OUT IX Trial.
作者: Lisette Okkels Jensen.;Michael Maeng.;Bent Raungaard.;Johnny Kahlert.;Julia Ellert.;Lars Jakobsen.;Anton Boel Villadsen.;Karsten Tange Veien.;Steen Dalby Kristensen.;Ole Ahlehoff.;Steen Carstensen.;Martin Kirk Christensen.;Christian Juhl Terkelsen.;Thomas Engstroem.;Knud Nørregaard Hansen.;Hans Erik Bøtker.;Jens Aaroe.;Troels Thim.;Leif Thuesen.;Philip Freeman.;Ahmed Aziz.;Ashkan Eftekhari.;Anders Junker.;Svend Eggert Jensen.;Jens Flensted Lassen.;Henrik Steen Hansen.;Evald Høj Christiansen.; .
来源: Circulation. 2020年141卷25期2052-2063页
In patients with increased bleeding risk, the biolimus A9-coated BioFreedom stent, a stainless steel drug-coated stent free from polymer, has shown superiority compared with a bare-metal stent. The aim of this study was to investigate whether the BioFreedom stent is noninferior to a modern ultrathin strut biodegradable polymer cobalt-chromium sirolimus-eluting Orsiro stent in an all-comers patient population treated with percutaneous coronary intervention.
7618. Urgent Pacemaker Implantation Rates in the Veneto Region of Italy After the COVID-19 Outbreak.
作者: Federico Migliore.;Alessandro Zorzi.;Dario Gregori.;Alvise Del Monte.;Pasquale Valerio Falzone.;Roberto Verlato.;Mariachiara Siciliano.;Sakis Themistoclakis.;Paolo China.;Domenico Marchese.;Giampaolo Pasquetto.;Barbara Ignatiuk.;Carlo Cernetti.;Enrico Giacomin.;Vittorio Calzolari.;Claudio Bilato.;Chiara Dalla Valle.;Gianfranco Mario Frigo.;Leonardo Marinaccio.;Salvatore Saccà.;Antonio Lupo.;Loris Roncon.;Lina Marcantoni.;Alberto Tosi.;Giovanni Turiano.;Franco Folino.;Martina Perazzolo Marra.;Luisa Cacciavillani.;Sabino Iliceto.; .
来源: Circ Arrhythm Electrophysiol. 2020年13卷6期e008722页 7619. Physical Activity and the Risk for Sudden Cardiac Death in Patients With Coronary Artery Disease.
作者: Mikko P Tulppo.;Antti M Kiviniemi.;Minna Lahtinen.;Olavi Ukkola.;Tomi Toukola.;Juha Perkiömäki.;M Juhani Junttila.;Heikki V Huikuri.
来源: Circ Arrhythm Electrophysiol. 2020年13卷6期e007908页
The association between leisure-time physical activity (LTPA) and the risk of sudden cardiac death (SCD) in coronary artery disease patients is not well known. We aim to assess whether there is an association between LTPA and the risk of SCD and non-SCD in patients with coronary artery disease.
7620. Triggered Ca2+ Waves Induce Depolarization of Maximum Diastolic Potential and Action Potential Prolongation in Dog Atrial Myocytes.
作者: Georg Gussak.;William Marszalec.;Shin Yoo.;Rishi Modi.;Caitlin O'Callaghan.;Gary L Aistrup.;Jonathan M Cordeiro.;Robert Goodrow.;Giedrius Kanaporis.;Lothar A Blatter.;Yohannes Shiferaw.;Rishi Arora.;Junlan Zhou.;Amy R Burrell.;J Andrew Wasserstrom.
来源: Circ Arrhythm Electrophysiol. 2020年13卷6期e008179页
We have identified a novel form of abnormal Ca2+ wave activity in normal and failing dog atrial myocytes which occurs during the action potential (AP) and is absent during diastole. The goal of this study was to determine if triggered Ca2+ waves affect cellular electrophysiological properties.
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