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7550. Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia.
作者: Stephen K Brannan.;Sharon Sawchak.;Andrew C Miller.;Jeffrey A Lieberman.;Steven M Paul.;Alan Breier.
来源: N Engl J Med. 2021年384卷8期717-726页
The muscarinic receptor agonist xanomeline has antipsychotic properties and is devoid of dopamine receptor-blocking activity but causes cholinergic adverse events. Trospium is a peripherally restricted muscarinic receptor antagonist that reduces peripheral cholinergic effects of xanomeline. The efficacy and safety of combined xanomeline and trospium in patients with schizophrenia are unknown.
7551. Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma.
作者: Nikhil C Munshi.;Larry D Anderson.;Nina Shah.;Deepu Madduri.;Jesús Berdeja.;Sagar Lonial.;Noopur Raje.;Yi Lin.;David Siegel.;Albert Oriol.;Philippe Moreau.;Ibrahim Yakoub-Agha.;Michel Delforge.;Michele Cavo.;Hermann Einsele.;Hartmut Goldschmidt.;Katja Weisel.;Alessandro Rambaldi.;Donna Reece.;Fabio Petrocca.;Monica Massaro.;Jamie N Connarn.;Shari Kaiser.;Payal Patel.;Liping Huang.;Timothy B Campbell.;Kristen Hege.;Jesús San-Miguel.
来源: N Engl J Med. 2021年384卷8期705-716页
Idecabtagene vicleucel (ide-cel, also called bb2121), a B-cell maturation antigen-directed chimeric antigen receptor (CAR) T-cell therapy, has shown clinical activity with expected CAR T-cell toxic effects in patients with relapsed and refractory multiple myeloma.
7552. Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality.
作者: David J A Jenkins.;Mahshid Dehghan.;Andrew Mente.;Shrikant I Bangdiwala.;Sumathy Rangarajan.;Kristie Srichaikul.;Viswanathan Mohan.;Alvaro Avezum.;Rafael Díaz.;Annika Rosengren.;Fernando Lanas.;Patricio Lopez-Jaramillo.;Wei Li.;Aytekin Oguz.;Rasha Khatib.;Paul Poirier.;Noushin Mohammadifard.;Andrea Pepe.;Khalid F Alhabib.;Jephat Chifamba.;Afzal Hussein Yusufali.;Romaina Iqbal.;Karen Yeates.;Khalid Yusoff.;Noorhassim Ismail.;Koon Teo.;Sumathi Swaminathan.;Xiaoyun Liu.;Katarzyna Zatońska.;Rita Yusuf.;Salim Yusuf.; .
来源: N Engl J Med. 2021年384卷14期1312-1322页
Most data regarding the association between the glycemic index and cardiovascular disease come from high-income Western populations, with little information from non-Western countries with low or middle incomes. To fill this gap, data are needed from a large, geographically diverse population.
7553. Risdiplam in Type 1 Spinal Muscular Atrophy.
作者: Giovanni Baranello.;Basil T Darras.;John W Day.;Nicolas Deconinck.;Andrea Klein.;Riccardo Masson.;Eugenio Mercuri.;Kristy Rose.;Muna El-Khairi.;Marianne Gerber.;Ksenija Gorni.;Omar Khwaja.;Heidemarie Kletzl.;Renata S Scalco.;Timothy Seabrook.;Paulo Fontoura.;Laurent Servais.; .
来源: N Engl J Med. 2021年384卷10期915-923页
Type 1 spinal muscular atrophy is a rare, progressive neuromuscular disease that is caused by low levels of functional survival of motor neuron (SMN) protein. Risdiplam is an orally administered, small molecule that modifies SMN2 pre-messenger RNA splicing and increases levels of functional SMN protein.
7554. BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting.
作者: Noa Dagan.;Noam Barda.;Eldad Kepten.;Oren Miron.;Shay Perchik.;Mark A Katz.;Miguel A Hernán.;Marc Lipsitch.;Ben Reis.;Ran D Balicer.
来源: N Engl J Med. 2021年384卷15期1412-1423页
As mass vaccination campaigns against coronavirus disease 2019 (Covid-19) commence worldwide, vaccine effectiveness needs to be assessed for a range of outcomes across diverse populations in a noncontrolled setting. In this study, data from Israel's largest health care organization were used to evaluate the effectiveness of the BNT162b2 mRNA vaccine.
7556. Hypothermic Machine Perfusion in Liver Transplantation - A Randomized Trial.
作者: Rianne van Rijn.;Ivo J Schurink.;Yvonne de Vries.;Aad P van den Berg.;Miriam Cortes Cerisuelo.;Sarwa Darwish Murad.;Joris I Erdmann.;Nicholas Gilbo.;Robbert J de Haas.;Nigel Heaton.;Bart van Hoek.;Volkert A L Huurman.;Ina Jochmans.;Otto B van Leeuwen.;Vincent E de Meijer.;Diethard Monbaliu.;Wojciech G Polak.;Jules J G Slangen.;Roberto I Troisi.;Aude Vanlander.;Jeroen de Jonge.;Robert J Porte.; .
来源: N Engl J Med. 2021年384卷15期1391-1401页
Transplantation of livers obtained from donors after circulatory death is associated with an increased risk of nonanastomotic biliary strictures. Hypothermic oxygenated machine perfusion of livers may reduce the incidence of biliary complications, but data from prospective, controlled studies are limited.
7557. Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma.
作者: Robert Motzer.;Boris Alekseev.;Sun-Young Rha.;Camillo Porta.;Masatoshi Eto.;Thomas Powles.;Viktor Grünwald.;Thomas E Hutson.;Evgeny Kopyltsov.;María J Méndez-Vidal.;Vadim Kozlov.;Anna Alyasova.;Sung-Hoo Hong.;Anil Kapoor.;Teresa Alonso Gordoa.;Jaime R Merchan.;Eric Winquist.;Pablo Maroto.;Jeffrey C Goh.;Miso Kim.;Howard Gurney.;Vijay Patel.;Avivit Peer.;Giuseppe Procopio.;Toshio Takagi.;Bohuslav Melichar.;Frederic Rolland.;Ugo De Giorgi.;Shirley Wong.;Jens Bedke.;Manuela Schmidinger.;Corina E Dutcus.;Alan D Smith.;Lea Dutta.;Kalgi Mody.;Rodolfo F Perini.;Dongyuan Xing.;Toni K Choueiri.; .
来源: N Engl J Med. 2021年384卷14期1289-1300页
Lenvatinib in combination with pembrolizumab or everolimus has activity against advanced renal cell carcinoma. The efficacy of these regimens as compared with that of sunitinib is unclear.
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