7521. Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2.
作者: Kimberly G Blumenthal.;Esther E Freeman.;Rebecca R Saff.;Lacey B Robinson.;Anna R Wolfson.;Ruth K Foreman.;Dean Hashimoto.;Aleena Banerji.;Lily Li.;Sara Anvari.;Erica S Shenoy.
来源: N Engl J Med. 2021年384卷13期1273-1277页 7531. Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia.
作者: Ivan O Rosas.;Norbert Bräu.;Michael Waters.;Ronaldo C Go.;Bradley D Hunter.;Sanjay Bhagani.;Daniel Skiest.;Mariam S Aziz.;Nichola Cooper.;Ivor S Douglas.;Sinisa Savic.;Taryn Youngstein.;Lorenzo Del Sorbo.;Antonio Cubillo Gracian.;David J De La Zerda.;Andrew Ustianowski.;Min Bao.;Sophie Dimonaco.;Emily Graham.;Balpreet Matharu.;Helen Spotswood.;Larry Tsai.;Atul Malhotra.
来源: N Engl J Med. 2021年384卷16期1503-1516页
Coronavirus disease 2019 (Covid-19) is associated with immune dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of tocilizumab, a monoclonal antibody against the interleukin-6 receptor, has resulted in better outcomes in patients with severe Covid-19 pneumonia in case reports and retrospective observational cohort studies. Data are needed from randomized, placebo-controlled trials.
7532. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.
作者: .;Anthony C Gordon.;Paul R Mouncey.;Farah Al-Beidh.;Kathryn M Rowan.;Alistair D Nichol.;Yaseen M Arabi.;Djillali Annane.;Abi Beane.;Wilma van Bentum-Puijk.;Lindsay R Berry.;Zahra Bhimani.;Marc J M Bonten.;Charlotte A Bradbury.;Frank M Brunkhorst.;Adrian Buzgau.;Allen C Cheng.;Michelle A Detry.;Eamon J Duffy.;Lise J Estcourt.;Mark Fitzgerald.;Herman Goossens.;Rashan Haniffa.;Alisa M Higgins.;Thomas E Hills.;Christopher M Horvat.;Francois Lamontagne.;Patrick R Lawler.;Helen L Leavis.;Kelsey M Linstrum.;Edward Litton.;Elizabeth Lorenzi.;John C Marshall.;Florian B Mayr.;Daniel F McAuley.;Anna McGlothlin.;Shay P McGuinness.;Bryan J McVerry.;Stephanie K Montgomery.;Susan C Morpeth.;Srinivas Murthy.;Katrina Orr.;Rachael L Parke.;Jane C Parker.;Asad E Patanwala.;Ville Pettilä.;Emma Rademaker.;Marlene S Santos.;Christina T Saunders.;Christopher W Seymour.;Manu Shankar-Hari.;Wendy I Sligl.;Alexis F Turgeon.;Anne M Turner.;Frank L van de Veerdonk.;Ryan Zarychanski.;Cameron Green.;Roger J Lewis.;Derek C Angus.;Colin J McArthur.;Scott Berry.;Steve A Webb.;Lennie P G Derde.
来源: N Engl J Med. 2021年384卷16期1491-1502页
The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear.
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