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7502. Exercise Capacity and Ventricular Remodeling After Transcatheter Ventricular Septal Defect Closure in Asymptomatic or Minimally Symptomatic Adolescents and Adults.
作者: Chun-An Chen.;Jou-Kou Wang.;Ming-Tai Lin.;Hsin-Hui Chiu.;Jui-Yu Hsu.;Shu-Man Lin.;Ya-Mei Chang.;Shuenn-Nan Chiu.;Chun-Wei Lu.;Mei-Hwan Wu.;Ming-Chun Yang.
来源: Circ Cardiovasc Interv. 2020年13卷6期e008813页
Transcatheter ventricular septal defect (VSD) closure is a safe and efficacious alternative to surgery. However, its benefits in asymptomatic or minimally symptomatic patients remain unknown.
7504. Predictors of Treatment Response Following Ultrasound-Facilitated Catheter-Directed Thrombolysis for Submassive and Massive Pulmonary Embolism: A SEATTLE II Substudy.
作者: Partha Sardar.;Gregory Piazza.;Samuel Z Goldhaber.;Ping-Yu Liu.;William Prabhu.;Peter Soukas.;Herbert D Aronow.
来源: Circ Cardiovasc Interv. 2020年13卷6期e008747页
Little is known about which factors predict improvement in clinical and imaging parameters among patients undergoing catheter-directed thrombolysis for submassive or massive pulmonary embolism. The identification of such predictors may allow for more appropriate patient selection for ultrasound-facilitated catheter-directed thrombolysis.
7505. Optimal Use of Vasodilators for Diagnosis of Microvascular Angina in the Cardiac Catheterization Laboratory.
作者: Haseeb Rahman.;Ozan M Demir.;Matthew Ryan.;Hannah McConkey.;Cian Scannell.;Howard Ellis.;Andrew Webb.;Amedeo Chiribiri.;Divaka Perera.
来源: Circ Cardiovasc Interv. 2020年13卷6期e009019页
Among patients with angina and nonobstructive coronary artery disease, those with coronary microvascular dysfunction have a poor outcome. Coronary microvascular dysfunction is usually diagnosed by assessing flow reserve with an endothelium-independent vasodilator like adenosine, but the optimal diagnostic threshold is unclear. Furthermore, the incremental value of testing endothelial function has never been assessed before. We sought to determine what pharmacological thresholds correspond to exercise pathophysiology and myocardial ischemia in patients with coronary microvascular dysfunction.
7506. Response to Letter Regarding Article, "Absence of Long-Term Benefit of Revascularization in Patients With Intermittent Claudication: Five-Year Results From the IRONIC Randomized Controlled Trial".
作者: Henrik Djerf.;Johan Millinger.;Mårten Falkenberg.;Lennart Jivegård.;Mikael Svensson.;Joakim Nordanstig.
来源: Circ Cardiovasc Interv. 2020年13卷6期e009385页 7507. Use of a Polygenic Risk Score Improves Prediction of Myocardial Injury After Non-Cardiac Surgery.
作者: Nicholas J Douville.;Ida Surakka.;Aleda Leis.;Christopher B Douville.;Whitney E Hornsby.;Chad M Brummett.;Sachin Kheterpal.;Cristen J Willer.;Milo Engoren.;Michael R Mathis.
来源: Circ Genom Precis Med. 2020年13卷4期e002817页
While postoperative myocardial injury remains a major driver of morbidity and mortality, the ability to accurately identify patients at risk remains limited despite decades of clinical research. The role of genetic information in predicting myocardial injury after noncardiac surgery (MINS) remains unknown and requires large scale electronic health record and genomic data sets.
7509. Letter by Ozden Tok and Celik Regarding Article, "Novel Echocardiographic Approach to Hemodynamic Phenotypes Predicts Outcome of Patients Hospitalized With Heart Failure".7510. Response by Mele et al to Letter Regarding Article, "Novel Echocardiographic Approach to Hemodynamic Phenotypes Predicts Outcome of Patients Hospitalized With Heart Failure".
作者: Donato Mele.;Gabriele Pestelli.;Frank Lloyd Dini.;Davide Dal Molin.;Vittorio Smarrazzo.;Filippo Trevisan.;Giovanni Andrea Luisi.;Roberto Ferrari.
来源: Circ Cardiovasc Imaging. 2020年13卷6期e011045页 7511. Antegrade Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction: A Simplified Technique From Bench to Bedside.
作者: John C Lisko.;Adam B Greenbaum.;Jaffar M Khan.;Norihiko Kamioka.;Patrick T Gleason.;Isida Byku.;Jose F Condado.;Andres Jadue.;Gaetano Paone.;Kendra J Grubb.;Jasleen Tiwana.;James M McCabe.;Toby Rogers.;Robert J Lederman.;Vasilis C Babaliaros.
来源: Circ Cardiovasc Interv. 2020年13卷6期e008903页
Intentional laceration of the anterior mitral leaflet (LAMPOON) is an effective adjunct to transcatheter mitral valve replacement that prevents left ventricular outflow tract (LVOT) obstruction. To date, LAMPOON has been performed in over 150 patients using a retrograde approach that can be technically challenging. A modified antegrade transseptal technique may simplify the procedure.
7515. Advancing Research on the Complex Interrelations Between Atrial Fibrillation and Heart Failure: A Report From a US National Heart, Lung, and Blood Institute Virtual Workshop.
作者: Sana M Al-Khatib.;Emelia J Benjamin.;Christine M Albert.;Alvaro Alonso.;Cynthia Chauhan.;Peng-Sheng Chen.;Anne B Curtis.;Patrice Desvigne-Nickens.;Jennifer E Ho.;Carolyn S P Lam.;Mark S Link.;Kristen K Patton.;Margaret M Redfield.;Michiel Rienstra.;Yves Rosenberg.;Renate Schnabel.;John A Spertus.;Lynne Warner Stevenson.;Mellanie True Hills.;Adriaan A Voors.;Lawton S Cooper.;Alan S Go.
来源: Circulation. 2020年141卷23期1915-1926页
The interrelationships between atrial fibrillation (AF) and heart failure (HF) are complex and poorly understood, yet the number of patients with AF and HF continues to increase worldwide. Thus, there is a need for initiatives that prioritize research on the intersection between AF and HF. This article summarizes the proceedings of a virtual workshop convened by the US National Heart, Lung, and Blood Institute to identify important research opportunities in AF and HF. Key knowledge gaps were reviewed and research priorities were proposed for characterizing the pathophysiological overlap and deleterious interactions between AF and HF; preventing HF in people with AF; preventing AF in individuals with HF; and addressing symptom burden and health status outcomes in AF and HF. These research priorities will hopefully help inform, encourage, and stimulate innovative, cost-efficient, and transformative studies to enhance the outcomes of patients with AF and HF.
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