7485. Five-Year Outcomes of PFO Closure or Antiplatelet Therapy for Cryptogenic Stroke.
作者: Scott E Kasner.;John F Rhodes.;Grethe Andersen.;Helle K Iversen.;Jens E Nielsen-Kudsk.;Magnus Settergren.;Christina Sjöstrand.;Risto O Roine.;David Hildick-Smith.;J David Spence.;Lars Søndergaard.; .
来源: N Engl J Med. 2021年384卷10期970-971页 7491. Spermatogonium-Derived Complete Hydatidiform Mole.
A complete hydatidiform mole (CHM) is a conceptus with only sperm-derived chromosomes. Here, we report on a CHM with genomic DNA identical to that of the paternal somatic cells. The CHM developed in a woman who had undergone intrauterine implantation of a blastocyst obtained through in vitro injection of a presumed round spermatid into one of her oocytes. The CHM was genetically identical to peripheral white cells of her husband and contained no maternally derived nuclear DNA. We hypothesize that a spermatogonium, rather than a round spermatid, was inadvertently selected for the procedure. The CHM developed into a gestational trophoblastic neoplasia, which resolved after chemotherapy. (Funded by the Japan Society for the Promotion of Science.).
7492. Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers.
作者: Eric J Duncavage.;Molly C Schroeder.;Michele O'Laughlin.;Roxanne Wilson.;Sandra MacMillan.;Andrew Bohannon.;Scott Kruchowski.;John Garza.;Feiyu Du.;Andrew E O Hughes.;Josh Robinson.;Emma Hughes.;Sharon E Heath.;Jack D Baty.;Julie Neidich.;Matthew J Christopher.;Meagan A Jacoby.;Geoffrey L Uy.;Robert S Fulton.;Christopher A Miller.;Jacqueline E Payton.;Daniel C Link.;Matthew J Walter.;Peter Westervelt.;John F DiPersio.;Timothy J Ley.;David H Spencer.
来源: N Engl J Med. 2021年384卷10期924-935页
Genomic analysis is essential for risk stratification in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Whole-genome sequencing is a potential replacement for conventional cytogenetic and sequencing approaches, but its accuracy, feasibility, and clinical utility have not been demonstrated.
7493. A Pragmatic, Randomized Clinical Trial of Gestational Diabetes Screening.
作者: Teresa A Hillier.;Kathryn L Pedula.;Keith K Ogasawara.;Kimberly K Vesco.;Caryn E S Oshiro.;Suzanne L Lubarsky.;Jan Van Marter.
来源: N Engl J Med. 2021年384卷10期895-904页
Gestational diabetes mellitus is common and is associated with an increased risk of adverse maternal and perinatal outcomes. Although experts recommend universal screening for gestational diabetes, consensus is lacking about which of two recommended screening approaches should be used.
7494. Antibody Responses in Seropositive Persons after a Single Dose of SARS-CoV-2 mRNA Vaccine.
作者: Florian Krammer.;Komal Srivastava.;Hala Alshammary.;Angela A Amoako.;Mahmoud H Awawda.;Katherine F Beach.;Maria C Bermúdez-González.;Dominika A Bielak.;Juan M Carreño.;Rachel L Chernet.;Lily Q Eaker.;Emily D Ferreri.;Daniel L Floda.;Charles R Gleason.;Joshua Z Hamburger.;Kaijun Jiang.;Giulio Kleiner.;Denise Jurczyszak.;Julia C Matthews.;Wanni A Mendez.;Ismail Nabeel.;Lubbertus C F Mulder.;Ariel J Raskin.;Kayla T Russo.;Ashley-Beathrese T Salimbangon.;Miti Saksena.;Amber S Shin.;Gagandeep Singh.;Levy A Sominsky.;Daniel Stadlbauer.;Ania Wajnberg.;Viviana Simon.
来源: N Engl J Med. 2021年384卷14期1372-1374页 7498. Neutralizing Activity of BNT162b2-Elicited Serum.
作者: Yang Liu.;Jianying Liu.;Hongjie Xia.;Xianwen Zhang.;Camila R Fontes-Garfias.;Kena A Swanson.;Hui Cai.;Ritu Sarkar.;Wei Chen.;Mark Cutler.;David Cooper.;Scott C Weaver.;Alexander Muik.;Ugur Sahin.;Kathrin U Jansen.;Xuping Xie.;Philip R Dormitzer.;Pei-Yong Shi.
来源: N Engl J Med. 2021年384卷15期1466-1468页 |