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7463. Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria.
作者: Peter Hillmen.;Jeff Szer.;Ilene Weitz.;Alexander Röth.;Britta Höchsmann.;Jens Panse.;Kensuke Usuki.;Morag Griffin.;Jean-Jacques Kiladjian.;Carlos de Castro.;Hisakazu Nishimori.;Lisa Tan.;Mohamed Hamdani.;Pascal Deschatelets.;Cedric Francois.;Federico Grossi.;Temitayo Ajayi.;Antonio Risitano.;Régis Peffault de Latour.
来源: N Engl J Med. 2021年384卷11期1028-1037页
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease characterized by chronic complement-mediated hemolysis. C5 inhibition controls intravascular hemolysis in untreated PNH but cannot address extravascular hemolysis. Pegcetacoplan, a pegylated peptide targeting proximal complement protein C3, potentially inhibits both intravascular and extravascular hemolysis.
7464. Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition.
作者: Lawrence Corey.;Peter B Gilbert.;Michal Juraska.;David C Montefiori.;Lynn Morris.;Shelly T Karuna.;Srilatha Edupuganti.;Nyaradzo M Mgodi.;Allan C deCamp.;Erika Rudnicki.;Yunda Huang.;Pedro Gonzales.;Robinson Cabello.;Catherine Orrell.;Javier R Lama.;Fatima Laher.;Erica M Lazarus.;Jorge Sanchez.;Ian Frank.;Juan Hinojosa.;Magdalena E Sobieszczyk.;Kyle E Marshall.;Pamela G Mukwekwerere.;Joseph Makhema.;Lindsey R Baden.;James I Mullins.;Carolyn Williamson.;John Hural.;M Juliana McElrath.;Carter Bentley.;Simbarashe Takuva.;Margarita M Gomez Lorenzo.;David N Burns.;Nicole Espy.;April K Randhawa.;Nidhi Kochar.;Estelle Piwowar-Manning.;Deborah J Donnell.;Nirupama Sista.;Philip Andrew.;James G Kublin.;Glenda Gray.;Julie E Ledgerwood.;John R Mascola.;Myron S Cohen.; .
来源: N Engl J Med. 2021年384卷11期1003-1014页
Whether a broadly neutralizing antibody (bnAb) can be used to prevent human immunodeficiency virus type 1 (HIV-1) acquisition is unclear.
7466. Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant.
作者: Shabir A Madhi.;Vicky Baillie.;Clare L Cutland.;Merryn Voysey.;Anthonet L Koen.;Lee Fairlie.;Sherman D Padayachee.;Keertan Dheda.;Shaun L Barnabas.;Qasim E Bhorat.;Carmen Briner.;Gaurav Kwatra.;Khatija Ahmed.;Parvinder Aley.;Sutika Bhikha.;Jinal N Bhiman.;As'ad E Bhorat.;Jeanine du Plessis.;Aliasgar Esmail.;Marisa Groenewald.;Elizea Horne.;Shi-Hsia Hwa.;Aylin Jose.;Teresa Lambe.;Matt Laubscher.;Mookho Malahleha.;Masebole Masenya.;Mduduzi Masilela.;Shakeel McKenzie.;Kgaogelo Molapo.;Andrew Moultrie.;Suzette Oelofse.;Faeezah Patel.;Sureshnee Pillay.;Sarah Rhead.;Hylton Rodel.;Lindie Rossouw.;Carol Taoushanis.;Houriiyah Tegally.;Asha Thombrayil.;Samuel van Eck.;Constantinos K Wibmer.;Nicholas M Durham.;Elizabeth J Kelly.;Tonya L Villafana.;Sarah Gilbert.;Andrew J Pollard.;Tulio de Oliveira.;Penny L Moore.;Alex Sigal.;Alane Izu.; .; .
来源: N Engl J Med. 2021年384卷20期1885-1898页
Assessment of the safety and efficacy of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different populations is essential, as is investigation of the efficacy of the vaccines against emerging SARS-CoV-2 variants of concern, including the B.1.351 (501Y.V2) variant first identified in South Africa.
7467. Disposable E-Cigarette Use among U.S. Youth - An Emerging Public Health Challenge.
作者: Teresa W Wang.;Andrea S Gentzke.;Linda J Neff.;Emily V Glidden.;Ahmed Jamal.;Eunice Park-Lee.;Chunfeng Ren.;Karen A Cullen.;Brian A King.;Karen A Hacker.
来源: N Engl J Med. 2021年384卷16期1573-1576页 7469. Donanemab in Early Alzheimer's Disease.
作者: Mark A Mintun.;Albert C Lo.;Cynthia Duggan Evans.;Alette M Wessels.;Paul A Ardayfio.;Scott W Andersen.;Sergey Shcherbinin.;JonDavid Sparks.;John R Sims.;Miroslaw Brys.;Liana G Apostolova.;Stephen P Salloway.;Daniel M Skovronsky.
来源: N Engl J Med. 2021年384卷18期1691-1704页
A hallmark of Alzheimer's disease is the accumulation of amyloid-β (Aβ) peptide. Donanemab, an antibody that targets a modified form of deposited Aβ, is being investigated for the treatment of early Alzheimer's disease.
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