7434. Abrocitinib versus Placebo or Dupilumab for Atopic Dermatitis.
作者: Thomas Bieber.;Eric L Simpson.;Jonathan I Silverberg.;Diamant Thaçi.;Carle Paul.;Andrew E Pink.;Yoko Kataoka.;Chia-Yu Chu.;Marco DiBonaventura.;Ricardo Rojo.;Jeremias Antinew.;Ileana Ionita.;Rodney Sinclair.;Seth Forman.;Jacek Zdybski.;Pinaki Biswas.;Bimal Malhotra.;Fan Zhang.;Hernan Valdez.; .
来源: N Engl J Med. 2021年384卷12期1101-1112页
The oral Janus kinase 1 (JAK1) inhibitor abrocitinib, which reduces interleukin-4 and interleukin-13 signaling, is being investigated for the treatment of atopic dermatitis. Data from trials comparing JAK1 inhibitors with monoclonal antibodies, such as dupilumab, that block interleukin-4 receptors are limited.
7435. Vaccine Efficacy of ALVAC-HIV and Bivalent Subtype C gp120-MF59 in Adults.
作者: Glenda E Gray.;Linda-Gail Bekker.;Fatima Laher.;Mookho Malahleha.;Mary Allen.;Zoe Moodie.;Nicole Grunenberg.;Yunda Huang.;Doug Grove.;Brittany Prigmore.;Jia J Kee.;David Benkeser.;John Hural.;Craig Innes.;Erica Lazarus.;Graeme Meintjes.;Nivashnee Naicker.;Dishiki Kalonji.;Maphoshane Nchabeleng.;Modulakgotla Sebe.;Nishanta Singh.;Philip Kotze.;Sheetal Kassim.;Thozama Dubula.;Vimla Naicker.;William Brumskine.;Cleon N Ncayiya.;Amy M Ward.;Nigel Garrett.;Girisha Kistnasami.;Zakir Gaffoor.;Pearl Selepe.;Philisiwe B Makhoba.;Matsontso P Mathebula.;Pamela Mda.;Tania Adonis.;Katlego S Mapetla.;Bontle Modibedi.;Tricia Philip.;Gladys Kobane.;Carter Bentley.;Shelly Ramirez.;Simbarashe Takuva.;Megan Jones.;Mpho Sikhosana.;Millicent Atujuna.;Michele Andrasik.;Nima S Hejazi.;Adrian Puren.;Lubbe Wiesner.;Sanjay Phogat.;Carlos Diaz Granados.;Marguerite Koutsoukos.;Olivier Van Der Meeren.;Susan W Barnett.;Niranjan Kanesa-Thasan.;James G Kublin.;M Juliana McElrath.;Peter B Gilbert.;Holly Janes.;Lawrence Corey.; .
来源: N Engl J Med. 2021年384卷12期1089-1100页
A safe, effective vaccine is essential to eradicating human immunodeficiency virus (HIV) infection. A canarypox-protein HIV vaccine regimen (ALVAC-HIV plus AIDSVAX B/E) showed modest efficacy in reducing infection in Thailand. An analogous regimen using HIV-1 subtype C virus showed potent humoral and cellular responses in a phase 1-2a trial in South Africa. Efficacy data and additional safety data were needed for this regimen in a larger population in South Africa.
7439. SARS-CoV-2 Infection after Vaccination in Health Care Workers in California.
作者: Jocelyn Keehner.;Lucy E Horton.;Michael A Pfeffer.;Christopher A Longhurst.;Robert T Schooley.;Judith S Currier.;Shira R Abeles.;Francesca J Torriani.
来源: N Engl J Med. 2021年384卷18期1774-1775页 7440. Antibody Responses after a Single Dose of SARS-CoV-2 mRNA Vaccine.
作者: Todd Bradley.;Elin Grundberg.;Rangaraj Selvarangan.;Cas LeMaster.;Elizabeth Fraley.;Dithi Banerjee.;Bradley Belden.;Daniel Louiselle.;Nick Nolte.;Rebecca Biswell.;Tomi Pastinen.;Angela Myers.;Jennifer Schuster.
来源: N Engl J Med. 2021年384卷20期1959-1961页 |