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7381. Response by Jackson et al to Letter Regarding Article, "Effects of Sacubitril-Valsartan Versus Valsartan in Women Compared With Men With Heart Failure and Preserved Ejection Fraction: Insights From PARAGON-HF".
作者: Alice M Jackson.;Pardeep S Jhund.;Scott D Solomon.;John J V McMurray.
来源: Circulation. 2020年142卷1期e5-e6页 7386. Letter by Wu and Zhao Regarding Article, "Effects of Sacubitril-Valsartan Versus Valsartan in Women Compared With Men With Heart Failure and Preserved Ejection Fraction: Insights From PARAGON-HF".7388. Regulation Without Representation: Cardiac Device Patient Knowledge and Attitudes About the FDA Regulatory Process.
作者: Emily P Zeitler.;Sana M Al-Khatib.;Rebecca Yapejian.;Connor C Tripp.;Samuel F Sears.
来源: Circ Arrhythm Electrophysiol. 2020年13卷8期e008561页 7389. Relationship Between Fractionated Signal Areas in the Atrial Muscle During Sinus Rhythm and Atrial Pacing and Non-Pulmonary Vein Foci: Novel Mapping Strategy.
作者: Jun Hirokami.;Kenichi Hiroshima.;Kyohei Yamaji.;Kengo Korai.;Michio Nagashima.;Masato Fukunaga.;Junji Morita.;Kei Yamamoto.;Kenji Ando.;Masahiko Goya.
来源: Circ Arrhythm Electrophysiol. 2020年13卷8期e008667页 7390. Late INa Blocker GS967 Supresses Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Type 2.
作者: Jungmin Hwang.;Tae Yun Kim.;Dmitry Terentyev.;Mingwang Zhong.;Anatoli Y Kabakov.;Peter Bronk.;Karuppiah Arunachalam.;Luiz Belardinelli.;Sridharan Rajamani.;Yukiko Kunitomo.;Zachary Pfeiffer.;Yichun Lu.;Xuwen Peng.;Katja E Odening.;Zhilin Qu.;Alain Karma.;Gideon Koren.;Bum-Rak Choi.
来源: Circ Arrhythm Electrophysiol. 2020年13卷8期e006875页
Long QT syndrome has been associated with sudden cardiac death likely caused by early afterdepolarizations (EADs) and polymorphic ventricular tachycardias (PVTs). Suppressing the late sodium current (INaL) may counterbalance the reduced repolarization reserve in long QT syndrome and prevent EADs and PVTs.
7391. Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome-Associated Cardiomyopathy.
作者: Ulrich Hanses.;Mandy Kleinsorge.;Lennart Roos.;Gökhan Yigit.;Yun Li.;Boris Barbarics.;Ibrahim El-Battrawy.;Huan Lan.;Malte Tiburcy.;Robin Hindmarsh.;Christof Lenz.;Gabriela Salinas.;Sebastian Diecke.;Christian Müller.;Ibrahim Adham.;Janine Altmüller.;Peter Nürnberg.;Thomas Paul.;Wolfram-Hubertus Zimmermann.;Gerd Hasenfuss.;Bernd Wollnik.;Lukas Cyganek.
来源: Circulation. 2020年142卷11期1059-1076页
Noonan syndrome (NS) is a multisystemic developmental disorder characterized by common, clinically variable symptoms, such as typical facial dysmorphisms, short stature, developmental delay, intellectual disability as well as cardiac hypertrophy. The underlying mechanism is a gain-of-function of the RAS-mitogen-activated protein kinase signaling pathway. However, our understanding of the pathophysiological alterations and mechanisms, especially of the associated cardiomyopathy, remains limited and effective therapeutic options are lacking.
7392. Can Pay-for Performance Incentive Levels be Determined Using a Cost-Effectiveness Framework?
作者: Ankur Pandya.;Djøra I Soeteman.;Ajay Gupta.;Hooman Kamel.;Alvin I Mushlin.;Meredith B Rosenthal.
来源: Circ Cardiovasc Qual Outcomes. 2020年13卷7期e006492页
Healthcare payers in the United States are increasingly tying provider payments to quality and value using pay-for-performance policies. Cost-effectiveness analysis quantifies value in healthcare but is not currently used to design or prioritize pay-for-performance strategies or metrics. Acute ischemic stroke care provides a useful application to demonstrate how simulation modeling can be used to determine cost-effective levels of financial incentives used in pay-for-performance policies and associated challenges with this approach.
7393. Incidence and Factors Associated With Major Amputation in Patients With Peripheral Artery Disease: Insights From the EUCLID Trial.
作者: Chandler A Long.;Hillary Mulder.;F Gerry R Fowkes.;Iris Baumgartner.;Jeffrey S Berger.;Brian G Katona.;Kenneth W Mahaffey.;Lars Norgren.;Juuso I Blomster.;Frank W Rockhold.;William R Hiatt.;Manesh R Patel.;W Schuyler Jones.;Mark R Nehler.
来源: Circ Cardiovasc Qual Outcomes. 2020年13卷7期e006399页
Peripheral artery disease (PAD) is associated with increased risk of mortality, cardiovascular morbidity, and major amputation. Data on major amputation from a large randomized trial that included a substantial cohort of patients without critical limb ischemia (CLI) have not been described. The objective was to describe the incidence and types of amputations in the EUCLID trial (Examining Use of Ticagrelor in Peripheral Artery Disease) population, subcategorize amputations in the CLI versus no CLI cohorts, and describe the events surrounding major amputation.
7394. Calcineurin Aβ-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy.
作者: Xiaofeng Li.;Jinliang Li.;Eliana C Martinez.;Alexander Froese.;Catherine L Passariello.;Kathryn Henshaw.;Francesca Rusconi.;Yang Li.;Qian Yu.;Hrishikesh Thakur.;Viacheslav O Nikolaev.;Michael S Kapiloff.
来源: Circulation. 2020年142卷10期948-962页
The Ca2+/calmodulin-dependent phosphatase calcineurin is a key regulator of cardiac myocyte hypertrophy in disease. An unexplained paradox is how the β isoform of the calcineurin catalytic A-subunit (CaNAβ) is required for induction of pathological myocyte hypertrophy, despite calcineurin Aα expression in the same cells. It is unclear how the pleiotropic second messenger Ca2+ drives excitation-contraction coupling while not stimulating hypertrophy by calcineurin in the normal heart. Elucidation of the mechanisms conferring this selectivity in calcineurin signaling should reveal new strategies for targeting the phosphatase in disease.
7396. Can Children Be Considered for Transradial Interventions?: Prospective Study of Sonographic Radial Artery Diameters.
作者: Ahmad Alehaideb.;Winston Ha.;Suzanne Bickford.;Adam A Dmytriw.;Kartik Bhatia.;Afsaneh Amirabadi.;Arun Mohanta.;Govind Chavhan.;Prakash Muthusami.
来源: Circ Cardiovasc Interv. 2020年13卷7期e009251页
Transradial intervention is increasingly replacing approaches, due to lower access complications, cost, and improved patient satisfaction. There are limited supporting data in the pediatric literature, largely due to concerns regarding arterial size. The objective of this study was to measure radial artery diameters in children across all age groups, to establish reference ranges for clinical use.
7397. Intensive Training and Real-Time Quality Control by a Physiology Core Laboratory: Lessons From DEFINE-PCI.
作者: Mitsuaki Matsumura.;Akiko Maehara.;Justin E Davies.;Andrew Sharp.;Habib Samady.;Arnold H Seto.;Ziad A Ali.;Gregg W Stone.;Manesh R Patel.;Allen Jeremias.
来源: Circ Cardiovasc Interv. 2020年13卷7期e009077页 7398. Cardiac Resynchronization Therapy and Risk of Recurrent Hospitalizations in Patients Without Left Bundle Branch Block: The Long-Term Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy.
作者: Himabindu Vidula.;Elizabeth Lee.;Scott McNitt.;Bronislava Polonsky.;Mehmet Aktas.;Spencer Rosero.;Arwa Younis.;Scott D Solomon.;Wojciech Zareba.;Valentina Kutyifa.;Ilan Goldenberg.
来源: Circ Heart Fail. 2020年13卷7期e006925页
Mild heart failure (HF) patients without left bundle branch block (LBBB) did not derive a significant reduction in risk of a HF event/death in the MADIT-CRT trial (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy). However, the efficacy of CRT with a defibrillator (CRT-D) may be modified after the development of the first hospitalization for HF (HHF). We aimed to study the effect of CRT-D on long-term risk of recurrent HHF in patients without LBBB in MADIT-CRT.
7400. Meta-Analysis of 26 638 Individuals Identifies Two Genetic Loci Associated With Left Ventricular Ejection Fraction.
作者: Hélène Choquet.;Khanh K Thai.;Chen Jiang.;Dilrini K Ranatunga.;Thomas J Hoffmann.;Alan S Go.;Alistair C Lindsay.;Margaret G Ehm.;Dawn M Waterworth.;Neil Risch.;Catherine Schaefer.
来源: Circ Genom Precis Med. 2020年13卷4期e002804页
Left ventricular ejection fraction (EF) is an indicator of cardiac function, usually assessed in individuals with heart failure and other cardiac conditions. Although family studies indicate that EF has an important genetic component with heritability estimates up to 0.61, to date only 6 EF-associated loci have been reported.
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