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7361. Frequent Tumor Burden Monitoring of Esophageal Squamous Cell Carcinoma With Circulating Tumor DNA Using Individually Designed Digital Polymerase Chain Reaction.
作者: Takeshi Iwaya.;Fumitaka Endo.;Fumiaki Takahashi.;Takashi Tokino.;Yasushi Sasaki.;Satoshi S Nishizuka.
来源: Gastroenterology. 2021年160卷1期463-465.e4页 7362. Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry.
作者: Colleen R Kelly.;Eugene F Yen.;Ari M Grinspan.;Stacy A Kahn.;Ashish Atreja.;James D Lewis.;Thomas A Moore.;David T Rubin.;Alison M Kim.;Sonya Serra.;Yanina Nersesova.;Lydia Fredell.;Dea Hunsicker.;Daniel McDonald.;Rob Knight.;Jessica R Allegretti.;Joel Pekow.;Imad Absah.;Ronald Hsu.;Jennifer Vincent.;Sahil Khanna.;Lyn Tangen.;Carl V Crawford.;Mark C Mattar.;Lea Ann Chen.;Monika Fischer.;Razvan I Arsenescu.;Paul Feuerstadt.;Jonathan Goldstein.;David Kerman.;Adam C Ehrlich.;Gary D Wu.;Loren Laine.
来源: Gastroenterology. 2021年160卷1期183-192.e3页
Fecal microbiota transplantation (FMT) is used commonly for treatment of Clostridioides difficile infections (CDIs), although prospective safety data are limited and real-world FMT practice and outcomes are not well described. The FMT National Registry was designed to assess FMT methods and both safety and effectiveness outcomes from North American FMT providers.
7363. Interleukin 33 Triggers Early Eosinophil-Dependent Events Leading to Metaplasia in a Chronic Model of Gastritis-Prone Mice.
作者: Carlo De Salvo.;Luca Pastorelli.;Christine P Petersen.;Ludovica F Buttò.;Kristine-Ann Buela.;Sara Omenetti.;Silviu A Locovei.;Shuvra Ray.;Hannah R Friedman.;Jacob Duijser.;Wei Xin.;Abdullah Osme.;Fabio Cominelli.;Ganapati H Mahabeleshwar.;Jason C Mills.;James R Goldenring.;Theresa T Pizarro.
来源: Gastroenterology. 2021年160卷1期302-316.e7页
Interleukin (IL)33/IL1F11 is an important mediator for the development of type 2 T-helper cell (Th2)-driven inflammatory disorders and has also been implicated in the pathogenesis of gastrointestinal (GI)-related cancers, including gastric carcinoma. We therefore sought to mechanistically determine IL33's potential role as a critical factor linking chronic inflammation and gastric carcinogenesis using gastritis-prone SAMP1/YitFc (SAMP) mice.
7364. AGA Clinical Practice Update on the Evaluation and Management of Seronegative Enteropathies: Expert Review.
作者: Maureen M Leonard.;Benjamin Lebwohl.;Alberto Rubio-Tapia.;Federico Biagi.
来源: Gastroenterology. 2021年160卷1期437-444页
Our aim was to provide a consensus statement for the best approaches for diagnosis and management of patients with suspected enteropathy, but negative results from serologic tests for celiac disease (seronegative enteropathy).
7365. Clinical Characteristics, Hospitalization, and Mortality Rates of Coronavirus Disease 2019 Among Liver Transplant Patients in the United States: A Multicenter Research Network Study.
作者: Emad Mansoor.;Abe Perez.;Mohannad Abou-Saleh.;Seth N Sclair.;Stanley Cohen.;Gregory S Cooper.;Alexandra Mills.;Kayla Schlick.;Ahmad Khan.
来源: Gastroenterology. 2021年160卷1期459-462.e1页 7366. Combinatorial Transcriptional Profiling of Mouse and Human Enteric Neurons Identifies Shared and Disparate Subtypes In Situ.
作者: Aaron A May-Zhang.;Eric Tycksen.;Austin N Southard-Smith.;Karen K Deal.;Joseph T Benthal.;Dennis P Buehler.;Mike Adam.;Alan J Simmons.;James R Monaghan.;Brittany K Matlock.;David K Flaherty.;S Steven Potter.;Ken S Lau.;E Michelle Southard-Smith.
来源: Gastroenterology. 2021年160卷3期755-770.e26页
The enteric nervous system (ENS) coordinates essential intestinal functions through the concerted action of diverse enteric neurons (ENs). However, integrated molecular knowledge of EN subtypes is lacking. To compare human and mouse ENs, we transcriptionally profiled healthy ENS from adult humans and mice. We aimed to identify transcripts marking discrete neuron subtypes and visualize conserved EN subtypes for humans and mice in multiple bowel regions.
7367. Steatohepatitis Impairs T-cell-Directed Immunotherapies Against Liver Tumors in Mice.
作者: Bernd Heinrich.;Zachary J Brown.;Laurence P Diggs.;Mathias Vormehr.;Chi Ma.;Varun Subramanyam.;Umberto Rosato.;Benjamin Ruf.;Juliane S Walz.;John C McVey.;Simon Wabitsch.;Qiong Fu.;Su Jong Yu.;Qianfei Zhang.;Chunwei W Lai.;Ugur Sahin.;Tim F Greten.
来源: Gastroenterology. 2021年160卷1期331-345.e6页
Nonalcoholic steatohepatitis causes loss of hepatic CD4+ T cells and promotes tumor growth. The liver is the most common site of distant metastases from a variety of malignancies, many of which respond to immunotherapy. We investigated the effects of steatohepatitis on the efficacy of immunotherapeutic agents against liver tumors in mice.
7368. Epidemiologic Burden and Treatment of Chronic Symptomatic Functional Bowel Disorders in the United States: A Nationwide Analysis.
作者: Christopher Ma.;Stephen E Congly.;Kerri L Novak.;Paul J Belletrutti.;Maitreyi Raman.;Matthew Woo.;Christopher N Andrews.;Yasmin Nasser.
来源: Gastroenterology. 2021年160卷1期88-98.e4页
Functional bowel disorders (FBDs) are the most common gastrointestinal problems managed by physicians. We aimed to assess the burden of chronic symptomatic FBDs on ambulatory care delivery in the United States and evaluate patterns of treatment.
7369. Mesenchymal Plasticity Regulated by Prrx1 Drives Aggressive Pancreatic Cancer Biology.
作者: Karin Feldmann.;Carlo Maurer.;Katja Peschke.;Steffen Teller.;Kathleen Schuck.;Katja Steiger.;Thomas Engleitner.;Rupert Öllinger.;Alice Nomura.;Nils Wirges.;Aristeidis Papargyriou.;Rim Sabrina Jahan Sarker.;Raphela Aranie Ranjan.;Zahra Dantes.;Wilko Weichert.;Anil K Rustgi.;Roland M Schmid.;Roland Rad.;Günter Schneider.;Dieter Saur.;Maximilian Reichert.
来源: Gastroenterology. 2021年160卷1期346-361.e24页
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibroblast-rich desmoplastic stroma. Cancer-associated fibroblasts (CAFs) have been shown to display a high degree of interconvertible states including quiescent, inflammatory, and myofibroblastic phenotypes; however, the mechanisms by which this plasticity is achieved are poorly understood. Here, we aim to elucidate the role of CAF plasticity and its impact on PDAC biology.
7370. Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2-related Disease.
作者: Mayte Suárez-Fariñas.;Minami Tokuyama.;Gabrielle Wei.;Ruiqi Huang.;Alexandra Livanos.;Divya Jha.;Anais Levescot.;Haritz Irizar.;Roman Kosoy.;Sascha Cording.;Wenhui Wang.;Bojan Losic.;Ryan C Ungaro.;Antonio Di'Narzo.;Gustavo Martinez-Delgado.;Maria Suprun.;Michael J Corley.;Aleksandar Stojmirovic.;Sander M Houten.;Lauren Peters.;Mark Curran.;Carrie Brodmerkel.;Jacqueline Perrigoue.;Joshua R Friedman.;Ke Hao.;Eric E Schadt.;Jun Zhu.;Huaibin M Ko.;Judy Cho.;Marla C Dubinsky.;Bruce E Sands.;Lishomwa Ndhlovu.;Nadine Cerf-Bensusan.;Andrew Kasarskis.;Jean-Frederic Colombel.;Noam Harpaz.;Carmen Argmann.;Saurabh Mehandru.
来源: Gastroenterology. 2021年160卷1期287-301.e20页
The presence of gastrointestinal symptoms and high levels of viral RNA in the stool suggest active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication within enterocytes.
7371. Effects of Early Placement of Transjugular Portosystemic Shunts in Patients With High-Risk Acute Variceal Bleeding: a Meta-analysis of Individual Patient Data.
作者: Oana Nicoară-Farcău.;Guohong Han.;Marika Rudler.;Debora Angrisani.;Alberto Monescillo.;Ferran Torres.;Georgina Casanovas.;Jaime Bosch.;Yong Lv.;Dominique Thabut.;Daiming Fan.;Virginia Hernández-Gea.;Juan Carlos García-Pagán.; .
来源: Gastroenterology. 2021年160卷1期193-205.e10页
Compared with drugs plus endoscopy, placement of transjugular portosystemic shunt within 72 hours of admission to the hospital (early or preventive transjugular intrahepatic portosystemic shunt [TIPS], also called preemptive TIPS) increases the proportion of high-risk patients with cirrhosis and acute variceal bleeding who survive for 1 year. However, the benefit of preemptive TIPS is less clear for patients with a Child-Pugh score of B and active bleeding (CP-B+AB). We performed an individual data meta-analysis to assess the efficacy of preemptive TIPS in these patients and identify factors associated with reduced survival of patients receiving preemptive TIPS.
7372. Sympathetic Input to Multiple Cell Types in Mouse and Human Colon Produces Region-Specific Responses.
作者: Kristen M Smith-Edwards.;Brian S Edwards.;Christina M Wright.;Sabine Schneider.;Kimberly A Meerschaert.;Lindsay L Ejoh.;Sarah A Najjar.;Marthe J Howard.;Kathryn M Albers.;Robert O Heuckeroth.;Brian M Davis.
来源: Gastroenterology. 2021年160卷4期1208-1223.e4页
The colon is innervated by intrinsic and extrinsic neurons that coordinate functions necessary for digestive health. Sympathetic input suppresses colon motility by acting on intrinsic myenteric neurons, but the extent of sympathetic-induced changes on large-scale network activity in myenteric circuits has not been determined. Compounding the complexity of sympathetic function, there is evidence that sympathetic transmitters can regulate activity in non-neuronal cells (such as enteric glia and innate immune cells).
7373. Effect of Acid Suppressants on the Risk of COVID-19: A Propensity Score-Matched Study Using UK Biobank.
作者: Xiude Fan.;Zhengwen Liu.;Tatsunori Miyata.;Srinivasan Dasarathy.;Daniel M Rotroff.;Xiaoqin Wu.;Kyle L Poulsen.;Laura E Nagy.
来源: Gastroenterology. 2021年160卷1期455-458.e5页 7374. Predicting Outcomes in Pediatric Crohn's Disease for Management Optimization: Systematic Review and Consensus Statements From the Pediatric Inflammatory Bowel Disease-Ahead Program.
作者: Amanda Ricciuto.;Martine Aardoom.;Esther Orlanski-Meyer.;Dan Navon.;Nicholas Carman.;Marina Aloi.;Jiri Bronsky.;Jan Däbritz.;Marla Dubinsky.;Séamus Hussey.;Peter Lewindon.;Javier Martín De Carpi.;Víctor Manuel Navas-López.;Marina Orsi.;Frank M Ruemmele.;Richard K Russell.;Gabor Veres.;Thomas D Walters.;David C Wilson.;Thomas Kaiser.;Lissy de Ridder.;Dan Turner.;Anne M Griffiths.; .
来源: Gastroenterology. 2021年160卷1期403-436.e26页
A better understanding of prognostic factors within the heterogeneous spectrum of pediatric Crohn's disease (CD) should improve patient management and reduce complications. We aimed to identify evidence-based predictors of outcomes with the goal of optimizing individual patient management.
7375. Artificial Intelligence System to Determine Risk of T1 Colorectal Cancer Metastasis to Lymph Node.
作者: Shin-Ei Kudo.;Katsuro Ichimasa.;Benjamin Villard.;Yuichi Mori.;Masashi Misawa.;Shoichi Saito.;Kinichi Hotta.;Yutaka Saito.;Takahisa Matsuda.;Kazutaka Yamada.;Toshifumi Mitani.;Kazuo Ohtsuka.;Akiko Chino.;Daisuke Ide.;Kenichiro Imai.;Yoshihiro Kishida.;Keiko Nakamura.;Yasumitsu Saiki.;Masafumi Tanaka.;Shu Hoteya.;Satoshi Yamashita.;Yusuke Kinugasa.;Masayoshi Fukuda.;Toyoki Kudo.;Hideyuki Miyachi.;Fumio Ishida.;Hayato Itoh.;Masahiro Oda.;Kensaku Mori.
来源: Gastroenterology. 2021年160卷4期1075-1084.e2页
In accordance with guidelines, most patients with T1 colorectal cancers (CRC) undergo surgical resection with lymph node dissection, despite the low incidence (∼10%) of metastasis to lymph nodes. To reduce unnecessary surgical resections, we used artificial intelligence to build a model to identify T1 colorectal tumors at risk for metastasis to lymph node and validated the model in a separate set of patients.
7376. Predicting Outcomes in Pediatric Ulcerative Colitis for Management Optimization: Systematic Review and Consensus Statements From the Pediatric Inflammatory Bowel Disease-Ahead Program.
作者: Esther Orlanski-Meyer.;Martine Aardoom.;Amanda Ricciuto.;Dan Navon.;Nicholas Carman.;Marina Aloi.;Jiri Bronsky.;Jan Däbritz.;Marla Dubinsky.;Séamus Hussey.;Peter Lewindon.;Javier Martin De Carpi.;Víctor Manuel Navas-López.;Marina Orsi.;Frank M Ruemmele.;Richard K Russell.;Gabor Veres.;Thomas D Walters.;David C Wilson.;Thomas Kaiser.;Lissy de Ridder.;Anne Griffiths.;Dan Turner.
来源: Gastroenterology. 2021年160卷1期378-402.e22页
A better understanding of prognostic factors in ulcerative colitis (UC) could improve patient management and reduce complications. We aimed to identify evidence-based predictors for outcomes in pediatric UC, which may be used to optimize treatment algorithms.
7379. DDIT4 Licenses Only Healthy Cells to Proliferate During Injury-induced Metaplasia.
作者: Zhi-Feng Miao.;Jing-Xu Sun.;Mahliyah Adkins-Threats.;Min-Jiao Pang.;Jun-Hua Zhao.;Xin Wang.;Kai-Wen Tang.;Zhen-Ning Wang.;Jason C Mills.
来源: Gastroenterology. 2021年160卷1期260-271.e10页
In stomach, metaplasia can arise from differentiated chief cells that become mitotic via paligenosis, a stepwise program. In paligenosis, mitosis initiation requires reactivation of the cellular energy hub mTORC1 after initial mTORC1 suppression by DNA damage induced transcript 4 (DDIT4 aka REDD1). Here, we use DDIT4-deficient mice and human cells to study how metaplasia increases tumorigenesis risk.
7380. Population-Level Configurations of Gut Mycobiome Across 6 Ethnicities in Urban and Rural China.
作者: Yang Sun.;Tao Zuo.;Chun Pan Cheung.;Wenxi Gu.;Yating Wan.;Fen Zhang.;Nan Chen.;Hui Zhan.;Yun Kit Yeoh.;Junkun Niu.;Yan Du.;Fengrui Zhang.;Yunling Wen.;Jun Yu.;Joseph J Y Sung.;Paul K S Chan.;Francis K L Chan.;Kunhua Wang.;Siew C Ng.;Yinglei Miao.
来源: Gastroenterology. 2021年160卷1期272-286.e11页
Beyond bacteria, the human gastrointestinal tract is host to a vast diversity of fungi, collectively known as the gut mycobiome. Little is known of the impact of geography, ethnicity, and urbanization on the gut mycobiome at a large population level. We aim to delineate the variation of human gut mycobiome and its association with host factors, environmental factors, and diets.
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