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7341. Association of Body Mass Index With Coronary Artery Calcium and Subsequent Cardiovascular Mortality: The Coronary Artery Calcium Consortium.
作者: Joseph C Jensen.;Zeina A Dardari.;Michael J Blaha.;Susan White.;Leslee J Shaw.;John Rumberger.;Alan Rozanski.;Daniel S Berman.;Matthew J Budoff.;Khurram Nasir.;Michael D Miedema.
来源: Circ Cardiovasc Imaging. 2020年13卷7期e009495页
Obesity is associated with higher risk for coronary artery calcium (CAC), but the relationship between body mass index (BMI) and mortality is complex and frequently paradoxical.
7347. Postischemic Administration of IL-1α Neutralizing Antibody Reduces Brain Damage and Neurological Deficit in Experimental Stroke.
作者: Luca Liberale.;Nicole R Bonetti.;Yustina M Puspitasari.;Lena Schwarz.;Alexander Akhmedov.;Fabrizio Montecucco.;Frank Ruschitzka.;Jürg H Beer.;Thomas F Lüscher.;John Simard.;Peter Libby.;Giovanni G Camici.
来源: Circulation. 2020年142卷2期187-189页 7349. Response by Raphael et al to the Letters Regarding Article, "Incidence, Trends, and Outcomes of Type 2 Myocardial Infarction in a Community Cohort".
作者: Claire E Raphael.;Véronique L Roger.;Yader Sandoval.;Mandeep Singh.;Rajiv Gulati.
来源: Circulation. 2020年142卷2期e29-e30页 7355. Long-Term Outcome After Ventricular Tachycardia Ablation in Nonischemic Cardiomyopathy: Late Potential Abolition and VT Noninducibility.
作者: Kenji Okubo.;Lorenzo Gigli.;Nicola Trevisi.;Luca Foppoli.;Andrea Radinovic.;Caterina Bisceglia.;Antonio Frontera.;Giuseppe D'Angelo.;Manuela Cireddu.;Gabriele Paglino.;Patrizio Mazzone.;Paolo Della Bella.
来源: Circ Arrhythm Electrophysiol. 2020年13卷8期e008307页
In patients with an ischemic cardiomyopathy (ICM), the combination of late potential (LP) abolition and postprocedural ventricular tachycardia (VT) noninducibility is known to be the desirable end point for a successful long-term outcome after VT ablation. We investigated whether LP abolition and VT noninducibilty have a similar impact on the outcomes of patients with non-ICMs (NICM) undergoing VT ablation.
7356. Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data.
作者: Bakhtawar K Mahmoodi.;Vinicius Tragante.;Marcus E Kleber.;Michael V Holmes.;Amand F Schmidt.;Raymond O McCubrey.;Laurence J Howe.;Kenan Direk.;Hooman Allayee.;Ekaterina V Baranova.;Peter S Braund.;Graciela E Delgado.;Niclas Eriksson.;Crystel M Gijsberts.;Yan Gong.;Jaana Hartiala.;Mahyar Heydarpour.;Gerard Pasterkamp.;Salma Kotti.;Pekka Kuukasjärvi.;Petra A Lenzini.;Daniel Levin.;Leo-Pekka Lyytikäinen.;Jochen D Muehlschlegel.;Christopher P Nelson.;Kjell Nikus.;Anna P Pilbrow.;W H Wilson Tang.;Sander W van der Laan.;Jessica van Setten.;Ragnar O Vilmundarson.;John Deanfield.;Panos Deloukas.;Frank Dudbridge.;Stefan James.;Ify R Mordi.;Andrej Teren.;Thomas O Bergmeijer.;Simon C Body.;Michiel Bots.;Ralph Burkhardt.;Rhonda M Cooper-DeHoff.;Sharon Cresci.;Nicolas Danchin.;Robert N Doughty.;Diederick E Grobbee.;Emil Hagström.;Stanley L Hazen.;Claes Held.;Imo E Hoefer.;G Kees Hovingh.;Julie A Johnson.;Marcin P Kaczor.;Mika Kähönen.;Olaf H Klungel.;Jari O Laurikka.;Terho Lehtimäki.;Anke H Maitland-van der Zee.;Ruth McPherson.;Colin N Palmer.;Adriaan O Kraaijeveld.;Carl J Pepine.;Marek Sanak.;Naveed Sattar.;Markus Scholz.;Tabassome Simon.;John A Spertus.;Alexandre F R Stewart.;Wojciech Szczeklik.;Joachim Thiery.;Frank L J Visseren.;Johannes Waltenberger.;A Mark Richards.;Chim C Lang.;Vicky A Cameron.;Axel Åkerblom.;Guillaume Pare.;Winfried März.;Nilesh J Samani.;Aroon D Hingorani.;Jurriën M Ten Berg.;Lars Wallentin.;Folkert W Asselbergs.;Riyaz S Patel.
来源: Circulation. 2020年142卷6期546-555页
Studies examining the role of factor V Leiden among patients at higher risk of atherothrombotic events, such as those with established coronary heart disease (CHD), are lacking. Given that coagulation is involved in the thrombus formation stage on atherosclerotic plaque rupture, we hypothesized that factor V Leiden may be a stronger risk factor for atherothrombotic events in patients with established CHD.
7357. Prospective Evaluation of Clinico-Pathological Predictors of Postoperative Atrial Fibrillation: An Ancillary Study From the OPERA Trial.
作者: Domenico Corradi.;Jeffrey E Saffitz.;Deborah Novelli.;Angeliki Asimaki.;Caterina Simon.;Emanuela Oldoni.;Serge Masson.;Jennifer M T A Meessen.;Rodolfo Monaco.;Roberta Manuguerra.;Roberto Latini.;Peter Libby.;Luigi Tavazzi.;Roberto Marchioli.;Luca Dozza.;Laura Cavallotti.;Aneta Aleksova.;Renato Gregorini.;Dariush Mozaffarian.
来源: Circ Arrhythm Electrophysiol. 2020年13卷8期e008382页
Postoperative atrial fibrillation (POAF) occurs in 30% to 50% of patients undergoing cardiac surgery and is associated with increased morbidity and mortality. Prospective identification of structural/molecular changes in atrial myocardium that correlate with myocardial injury and precede and predict risk of POAF may identify new molecular pathways and targets for prevention of this common morbid complication.
7358. Cardiac Arrest Risk During Acute Infections: Systemic Inflammation Directly Prolongs QTc Interval via Cytokine-Mediated Effects on Potassium Channel Expression.
作者: Pietro Enea Lazzerini.;Maurizio Acampa.;Franco Laghi-Pasini.;Iacopo Bertolozzi.;Francesco Finizola.;Francesca Vanni.;Mariarita Natale.;Stefania Bisogno.;Gabriele Cevenini.;Alessandra Cartocci.;Beatrice Giabbani.;Nicola Migliacci.;Antonio D'Errico.;Alexander Dokollari.;Massimo Maccherini.;Mohamed Boutjdir.;Pier Leopoldo Capecchi.
来源: Circ Arrhythm Electrophysiol. 2020年13卷8期e008627页
During acute infections, the risk of malignant ventricular arrhythmias is increased, partly because of a higher propensity to develop QTc prolongation. Although it is generally believed that QTc changes almost exclusively result from concomitant treatment with QT-prolonging antimicrobials, direct effects of inflammatory cytokines on ventricular repolarization are increasingly recognized. We hypothesized that systemic inflammation per se can significantly prolong QTc during acute infections, via cytokine-mediated changes in K+ channel expression.
7359. Ion Channel and Structural Remodeling in Obesity-Mediated Atrial Fibrillation.
作者: Mark D McCauley.;Liang Hong.;Arvind Sridhar.;Ambili Menon.;Srikanth Perike.;Meihong Zhang.;Ivson Bezerra da Silva.;JiaJie Yan.;Marcelo G Bonini.;Xun Ai.;Jalees Rehman.;Dawood Darbar.
来源: Circ Arrhythm Electrophysiol. 2020年13卷8期e008296页
Epidemiological studies have established obesity as an independent risk factor for atrial fibrillation (AF), but the underlying pathophysiological mechanisms remain unclear. Reduced cardiac sodium channel expression is a known causal mechanism in AF. We hypothesized that obesity decreases Nav1.5 expression via enhanced oxidative stress, thus reducing INa, and enhancing susceptibility to AF.
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