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7273. County Differences in Liver Mortality in the United States: Impact of Sociodemographics, Disease Risk Factors, and Access to Care.
作者: David Goldberg.;Katherine Ross-Driscoll.;Raymond Lynch.
来源: Gastroenterology. 2021年160卷4期1140-1150.e1页
Data have demonstrated state-wide variability in mortality rates from liver disease (cirrhosis + hepatocellular carcinoma), but data are lacking at the local level (eg, county) to identify factors associated with variability in liver disease-related mortality and hotspots of liver disease mortality.
7274. The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions.
作者: M Blanca Piazuelo.;Luis E Bravo.;Robertino M Mera.;M Constanza Camargo.;Juan C Bravo.;Alberto G Delgado.;M Kay Washington.;Alicia Rosero.;Luz S Garcia.;Jose L Realpe.;Sandra P Cifuentes.;Douglas R Morgan.;Richard M Peek.;Pelayo Correa.;Keith T Wilson.
来源: Gastroenterology. 2021年160卷4期1106-1117.e3页
Helicobacter pylori eradication and endoscopic surveillance of gastric precancerous lesions are strategies to reduce gastric cancer (GC) risk. To our knowledge, this study is the longest prospective cohort of an H pylori eradication trial in a Hispanic population.
7276. Wnt Signaling Shapes the Histologic Variation in Diffuse Gastric Cancer.
作者: Kazuhiro Togasaki.;Shinya Sugimoto.;Yuki Ohta.;Kosaku Nanki.;Mami Matano.;Sirirat Takahashi.;Masayuki Fujii.;Takanori Kanai.;Toshiro Sato.
来源: Gastroenterology. 2021年160卷3期823-830页
Diffuse-type gastric cancer (GC) is currently subdivided into signet-ring cell carcinoma (SRCC) and non-SRCC, referred to as poorly cohesive carcinoma not otherwise specified (PCC-NOS). Although these subtypes are considered to be independent, they often coexist in the same tumors, raising a question of whether they clonally differ or not. To tackle this question, we established an experimental platform for human diffuse GC that enables accurate modeling of histologic subtypes.
7277. Colonoscopy With Polypectomy Reduces Long-Term Incidence of Colorectal Cancer in Both Men and Women: Extended Results From the Minnesota Colon Cancer Control Study.
作者: Aasma Shaukat.;Michael Shyne.;Jack S Mandel.;Dale Snover.;Timothy R Church.
来源: Gastroenterology. 2021年160卷4期1397-1399.e3页 7278. RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target.
作者: Huarong Chen.;Shanshan Gao.;Weixin Liu.;Chi-Chun Wong.;Jianfeng Wu.;Jingtong Wu.;Dabin Liu.;Hongyan Gou.;Wei Kang.;Jianning Zhai.;Chuangen Li.;Hao Su.;Shiyan Wang.;Fraser Soares.;Jiahuai Han.;Housheng Hansen He.;Jun Yu.
来源: Gastroenterology. 2021年160卷4期1284-1300.e16页
RNA N6-methyladenosine (m6A) modification has recently emerged as a new regulatory mechanism in cancer progression. We aimed to explore the role of the m6A regulatory enzyme METTL3 in colorectal cancer (CRC) pathogenesis and its potential as a therapeutic target.
7279. Paneth Cell Alertness to Pathogens Maintained by Vitamin D Receptors.
作者: Rong Lu.;Yong-Guo Zhang.;Yinglin Xia.;Jilei Zhang.;Arthur Kaser.;Richard Blumberg.;Jun Sun.
来源: Gastroenterology. 2021年160卷4期1269-1283页
Vitamin D exerts a regulatory role over mucosal immunity via the vitamin D receptor (VDR). Although Paneth cells and their products are known to regulate the commensal and pathogenic microbiota, the role that VDRs in Paneth cells play in these responses is unknown.
7280. Single-Nucleus and In Situ RNA-Sequencing Reveal Cell Topographies in the Human Pancreas.
作者: Luca Tosti.;Yan Hang.;Olivia Debnath.;Sebastian Tiesmeyer.;Timo Trefzer.;Katja Steiger.;Foo Wei Ten.;Sören Lukassen.;Simone Ballke.;Anja A Kühl.;Simone Spieckermann.;Rita Bottino.;Naveed Ishaque.;Wilko Weichert.;Seung K Kim.;Roland Eils.;Christian Conrad.
来源: Gastroenterology. 2021年160卷4期1330-1344.e11页
Molecular evidence of cellular heterogeneity in the human exocrine pancreas has not been yet established because of the local concentration and cascade of hydrolytic enzymes that can rapidly degrade cells and RNA upon pancreatic resection. We sought to better understand the heterogeneity and cellular composition of the pancreas in neonates and adults in healthy and diseased conditions using single-cell sequencing approaches.
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