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7262. Effect of Evolocumab on Atherogenic Lipoproteins During the Peri- and Early Postinfarction Period: A Placebo-Controlled, Randomized Trial.
作者: Thorsten M Leucker.;Michael J Blaha.;Steven R Jones.;Michael A Vavuranakis.;Marlene S Williams.;Hong Lai.;Thomas H Schindler.;Jacqueline Latina.;Steven P Schulman.;Gary Gerstenblith.
来源: Circulation. 2020年142卷4期419-421页 7267. Anatomical Distribution of Ectopy-Triggering Plexuses in Patients With Atrial Fibrillation.
作者: Min-Young Kim.;Belinda C Sandler.;Markus B Sikkel.;Christopher D Cantwell.;Kevin M Leong.;Vishal Luther.;Louisa Malcolme-Lawes.;Michael Koa-Wing.;Fu Siong Ng.;Norman Qureshi.;Afzal Sohaib.;Zachary I Whinnett.;Michael Fudge.;Elaine Lim.;Michelle Todd.;Ian Wright.;Nicholas S Peters.;Phang Boon Lim.;Nicholas W F Linton.;Prapa Kanagaratnam.
来源: Circ Arrhythm Electrophysiol. 2020年13卷9期e008715页 7268. Flutter Wave Morphology of Peri-Mitral Atrial Flutters Is Mainly Determined by Right Atrial Activation: Insights From High-Resolution Mapping.
作者: Wei Hu.;Dongchen Zhou.;Baotong Hua.;Gang Yang.;Hongwu Chen.;Weizu Ju.;Mingfang Li.;Fengxiang Zhang.;Liangrong Zheng.;Minglong Chen.
来源: Circ Arrhythm Electrophysiol. 2020年13卷9期e008446页
Peri-mitral atrial flutters frequently develop post-atrial fibrillation ablation or postcardiac surgery. The determinants of the flutter wave morphology on surface ECG have been less studied.
7269. Stabilizer Cell Gene Therapy: A Less-Is-More Strategy to Prevent Cardiac Arrhythmias.
作者: Michael B Liu.;Silvia G Priori.;Zhilin Qu.;James N Weiss.
来源: Circ Arrhythm Electrophysiol. 2020年13卷9期e008420页
In cardiac gene therapy to improve contractile function, achieving gene expression in the majority of cardiac myocytes is essential. In preventing cardiac arrhythmias, however, this goal may not be as important since transduction efficiencies as low as 40% suppressed ventricular arrhythmias in genetically modified mice with catecholaminergic polymorphic ventricular tachycardia.
7270. Ablation of Atrial Fibrillation Without Left Atrial Appendage Imaging in Patients Treated With Direct Oral Anticoagulants.
作者: Mohamed Diab.;Oussama M Wazni.;Walid I Saliba.;Khaldoun G Tarakji.;Jad A Ballout.;Erika Hutt.;John Rickard.;Bryan Baranowski.;Patrick Tchou.;Mandeep Bhargava.;Mina Chung.;Niraj Varma.;David O Martin.;Thomas Dresing.;Thomas Callahan.;Daniel Cantillon.;Mohamed Kanj.;Ayman A Hussein.
来源: Circ Arrhythm Electrophysiol. 2020年13卷9期e008301页
Many centers continue to routinely perform transesophageal echocardiograms before atrial fibrillation (AF) ablation procedures in patients treated with direct oral anticoagulants (DOACs). One study suggested that the procedures could be done without transesophageal echocardiogram but used intracardiac echocardiography imaging of the appendage from the right ventricular outflow. This study aimed to assess the safety of ablation for AF without transesophageal echocardiogram screening or intracardiac echocardiography imaging of the appendage in DOAC compliant patients.
7271. Aging Disrupts Normal Time-of-Day Variation in Cardiac Electrophysiology.
作者: Zhen Wang.;Srinivas Tapa.;Samantha D Francis Stuart.;Lianguo Wang.;Julie Bossuyt.;Brian P Delisle.;Crystal M Ripplinger.
来源: Circ Arrhythm Electrophysiol. 2020年13卷9期e008093页
Cardiac gene expression and arrhythmia occurrence have time-of-day variation; however, daily changes in cardiac electrophysiology, arrhythmia susceptibility, and Ca2+ handling have not been characterized. Furthermore, how these patterns change with age is unknown.
7272. Procedural Patterns and Safety of Atrial Fibrillation Ablation: Findings From Get With The Guidelines-Atrial Fibrillation.
作者: Zak Loring.;DaJuanicia N Holmes.;Roland A Matsouaka.;Anne B Curtis.;John D Day.;Nihar Desai.;Kenneth A Ellenbogen.;Gregory K Feld.;Gregg C Fonarow.;David S Frankel.;Jodie L Hurwitz.;Bradley P Knight.;Jose A Joglar.;Andrea M Russo.;Mandeep S Sidhu.;Mintu P Turakhia.;William R Lewis.;Jonathan P Piccini.
来源: Circ Arrhythm Electrophysiol. 2020年13卷9期e007944页
Catheter ablation is an increasingly used treatment for symptomatic atrial fibrillation (AF). However, there are limited prospective, nationwide data on patient selection and procedural characteristics. This study describes patient characteristics, techniques, treatment patterns, and safety outcomes of patients undergoing AF ablation.
7273. Multiple Vulnerabilities to Health Disparities and Incident Heart Failure Hospitalization in the REGARDS Study.
作者: Laura C Pinheiro.;Evgeniya Reshetnyak.;Madeline R Sterling.;Emily B Levitan.;Monika M Safford.;Parag Goyal.
来源: Circ Cardiovasc Qual Outcomes. 2020年13卷8期e006438页
Socially determined vulnerabilities (SDVs) to health disparities often cluster within the same individual. SDVs are separately associated with increased risk of heart failure (HF). The objective of this study was to determine the cumulative effect of SDVs to health disparities on incident HF hospitalization.
7274. Impact of the COVID-19 Pandemic on a Tertiary-Level Electrophysiology Laboratory in Italy.
作者: Paolo Compagnucci.;Giovanni Volpato.;Riccardo Pascucci.;Umberto Falanga.;Agostino Misiani.;Silvano Molini.;Giulio Spinucci.;Laura Cipolletta.;Manuel Conti.;Gino Grifoni.;Laura Carboni.;Gian Piero Perna.;Christopher Munch.;Marco Di Eusanio.;Alessandro Capucci.;Michela Casella.;Federico Guerra.;Antonio Dello Russo.
来源: Circ Arrhythm Electrophysiol. 2020年13卷9期e008774页 7275. Incidence and Predictors of Very Late Recurrence of Atrial Fibrillation Following Cryoballoon Pulmonary Vein Isolation.
作者: Dan L Musat.;Nicolle S Milstein.;Advay Bhatt.;Tina C Sichrovsky.;Mark W Preminger.;Carissa Pistilli.;Michael Rozylowicz.;Richard E Shaw.;Suneet Mittal.
来源: Circ Arrhythm Electrophysiol. 2020年13卷9期e008646页
A very late recurrence (VLR) of atrial fibrillation (AF) is considered present when the first recurrence of AF occurs ≥12 months following ablation. Prior studies characterizing VLR have not used an implantable loop recorder for ECG monitoring. Thus, it is unknown whether VLR truly occurs or whether these patients have simply had unrecognized AF. Our objective was to assess the incidence and predictors of VLR in patients who underwent cryoballoon pulmonary vein isolation alone, had an implantable loop recorder, and were confirmed AF free for at least 1 year.
7276. Relationship of Shock Energy to Impedance During Subcutaneous Implantable Cardioverter-Defibrillator Testing.
作者: Joshua E Payne.;Patrick Badertscher.;Michael E Field.;J Lacy Sturdivant.;Michael R Gold.
来源: Circ Arrhythm Electrophysiol. 2020年13卷9期e008631页 7277. Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100-Reactive CD4+ T-Regulatory Cells.
作者: Dennis Wolf.;Teresa Gerhardt.;Holger Winkels.;Nathaly Anto Michel.;Akula Bala Pramod.;Yanal Ghosheh.;Simon Brunel.;Konrad Buscher.;Jacqueline Miller.;Sara McArdle.;Livia Baas.;Kouji Kobiyama.;Melanie Vassallo.;Erik Ehinger.;Thamotharampillai Dileepan.;Amal Ali.;Maximilian Schell.;Zbigniew Mikulski.;Daniel Sidler.;Takayuki Kimura.;Xia Sheng.;Hauke Horstmann.;Sophie Hansen.;Lucia Sol Mitre.;Peter Stachon.;Ingo Hilgendorf.;Dalia E Gaddis.;Catherine Hedrick.;Chris A Benedict.;Bjoern Peters.;Andreas Zirlik.;Alessandro Sette.;Klaus Ley.
来源: Circulation. 2020年142卷13期1279-1293页
Throughout the inflammatory response that accompanies atherosclerosis, autoreactive CD4+ T-helper cells accumulate in the atherosclerotic plaque. Apolipoprotein B100 (apoB), the core protein of low-density lipoprotein, is an autoantigen that drives the generation of pathogenic T-helper type 1 (TH1) cells with proinflammatory cytokine secretion. Clinical data suggest the existence of apoB-specific CD4+ T cells with an atheroprotective, regulatory T cell (Treg) phenotype in healthy individuals. Yet, the function of apoB-reactive Tregs and their relationship with pathogenic TH1 cells remain unknown.
7278. IL-6 (Interleukin 6) Blockade and Heart Rate Corrected QT Interval Prolongation in COVID-19.
作者: Pietro Enea Lazzerini.;Franco Laghi-Pasini.;Maurizio Acampa.;Mohamed Boutjdir.;Pier Leopoldo Capecchi.
来源: Circ Arrhythm Electrophysiol. 2020年13卷9期e008791页 7279. Speckle-Tracking Strain Echocardiography in the Assessment of Myocardial Mechanics in Patients With Idiopathic Ventricular Arrhythmias: A Longitudinal Follow-Up Study.
作者: Siddharth J Trivedi.;Timothy Campbell.;Luke Stefani.;Saurabh Kumar.;Liza Thomas.
来源: Circ Arrhythm Electrophysiol. 2020年13卷9期e008748页 7280. Applicability of the MADIT-CRT Response Score for Prediction of Long-Term Clinical and Arrhythmic Events by QRS Morphology.
作者: Arwa Younis.;May Goldenberg.;Valentina Kutyifa.;Bronislava Polonsky.;Scott Mcnitt.;Wojciech Zareba.;Gregory Golovchiner.;Mehmet K Aktas.;Alon Barsheshet.
来源: Circ Arrhythm Electrophysiol. 2020年13卷9期e008499页 |