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7182. High-Resolution Transcriptomic Profiling of the Heart During Chronic Stress Reveals Cellular Drivers of Cardiac Fibrosis and Hypertrophy.
作者: Micheal A McLellan.;Daniel A Skelly.;Malathi S I Dona.;Galen T Squiers.;Gabriella E Farrugia.;Taylah L Gaynor.;Charles D Cohen.;Raghav Pandey.;Henry Diep.;Antony Vinh.;Nadia A Rosenthal.;Alexander R Pinto.
来源: Circulation. 2020年142卷15期1448-1463页
Cardiac fibrosis is a key antecedent to many types of cardiac dysfunction including heart failure. Physiological factors leading to cardiac fibrosis have been recognized for decades. However, the specific cellular and molecular mediators that drive cardiac fibrosis, and the relative effect of disparate cell populations on cardiac fibrosis, remain unclear.
7184. Cangrelor, Tirofiban, and Chewed or Standard Prasugrel Regimens in Patients With ST-Segment-Elevation Myocardial Infarction: Primary Results of the FABOLUS-FASTER Trial.
作者: Giuseppe Gargiulo.;Giovanni Esposito.;Marisa Avvedimento.;Michael Nagler.;Pietro Minuz.;Gianluca Campo.;Felice Gragnano.;Negar Manavifar.;Raffaele Piccolo.;Matteo Tebaldi.;Plinio Cirillo.;Lukas Hunziker.;Pascal Vranckx.;Sergio Leonardi.;Dik Heg.;Stephan Windecker.;Marco Valgimigli.
来源: Circulation. 2020年142卷5期441-454页
Standard administration of newer oral P2Y12 inhibitors, including prasugrel or ticagrelor, provides suboptimal early inhibition of platelet aggregation (IPA) in patients with ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention. We aimed to investigate the effects of cangrelor, tirofiban, and prasugrel, administered as chewed or integral loading dose, on IPA in patients undergoing primary percutaneous coronary intervention.
7185. Dual Antiplatelet Therapy After Percutaneous Coronary Intervention and Drug-Eluting Stents: A Systematic Review and Network Meta-Analysis.
作者: Safi U Khan.;Maninder Singh.;Shahul Valavoor.;Muhammad U Khan.;Ahmad N Lone.;Muhammad Zia Khan.;Muhammad Shahzeb Khan.;Preethi Mani.;Samir R Kapadia.;Erin D Michos.;Gregg W Stone.;Ankur Kalra.;Deepak L Bhatt.
来源: Circulation. 2020年142卷15期1425-1436页
The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention with drug-eluting stents remains uncertain. We compared short-term (<6-month) DAPT followed by aspirin or P2Y12 inhibitor monotherapy; midterm (6-month) DAPT; 12-month DAPT; and extended-term (>12-month) DAPT after percutaneous coronary intervention with drug-eluting stents.
7186. US Mortality Attributable to Congenital Heart Disease Across the Lifespan From 1999 Through 2017 Exposes Persistent Racial/Ethnic Disparities.
作者: Keila N Lopez.;Shaine A Morris.;S Kristen Sexson Tejtel.;Andre Espaillat.;Jason L Salemi.
来源: Circulation. 2020年142卷12期1132-1147页
Congenital heart disease (CHD) accounts for ≈40% of deaths in US children with birth defects. Previous US data from 1999 to 2006 demonstrated an overall decrease in CHD mortality. Our study aimed to assess current trends in US mortality related to CHD from infancy to adulthood over the past 19 years and determine differences by sex and race/ethnicity.
7187. Genetic Associations With Plasma Angiotensin Converting Enzyme 2 Concentration: Potential Relevance to COVID-19 Risk.
作者: Christopher P Nelson.;Iziah E Sama.;Veryan Codd.;Thomas R Webb.;Shu Ye.;Chim C Lang.;Adriaan A Voors.;Leong L Ng.;Nilesh J Samani.
来源: Circulation. 2020年142卷11期1117-1119页 7188. Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2-Mediated Myocarditis.
作者: Nathan R Tucker.;Mark Chaffin.;Kenneth C Bedi.;Irinna Papangeli.;Amer-Denis Akkad.;Alessandro Arduini.;Sikander Hayat.;Gökcen Eraslan.;Christoph Muus.;Roby P Bhattacharyya.;Christian M Stegmann.; .;Kenneth B Margulies.;Patrick T Ellinor.; .
来源: Circulation. 2020年142卷7期708-710页
Supplemental Digital Content is available in the text.
7189. Exposure to Air Pollution and Particle Radioactivity With the Risk of Ventricular Arrhythmias.
作者: Adjani A Peralta.;Mark S Link.;Joel Schwartz.;Heike Luttmann-Gibson.;Douglas W Dockery.;Annelise Blomberg.;Yaguang Wei.;Murray A Mittleman.;Diane R Gold.;Francine Laden.;Brent A Coull.;Petros Koutrakis.
来源: Circulation. 2020年142卷9期858-867页
Individuals are exposed to air pollution and ionizing radiation from natural sources through inhalation of particles. This study investigates the association between cardiac arrhythmias and short-term exposures to fine particulate matter (particulate matter ≤2.5 µm aerodynamic diameter; PM2.5) and particle radioactivity.
7190. Dapagliflozin and Cardiac, Kidney, and Limb Outcomes in Patients With and Without Peripheral Artery Disease in DECLARE-TIMI 58.
作者: Marc P Bonaca.;Stephen D Wiviott.;Thomas A Zelniker.;Ofri Mosenzon.;Deepak L Bhatt.;Lawrence A Leiter.;Darren K McGuire.;Erica L Goodrich.;Remo Holanda De Mendonca Furtado.;John P H Wilding.;Avivit Cahn.;Ingrid A M Gause-Nilsson.;Per Johanson.;Martin Fredriksson.;Peter A Johansson.;Anna Maria Langkilde.;Itamar Raz.;Marc S Sabatine.
来源: Circulation. 2020年142卷8期734-747页
Patients with peripheral artery disease (PAD) are at heightened risk of cardiovascular complications. The sodium-glucose cotransporter 2 inhibitor dapagliflozin reduces the risk for hospitalization for heart failure (HHF) and kidney events in patients with type 2 diabetes mellitus. An increased risk of amputation has been observed with canagliflozin in 1 previous trial. We examined cardiovascular and kidney efficacy and the risk of limb-related events in patients with and without PAD in an exploratory analysis.
7191. A Notch3-Marked Subpopulation of Vascular Smooth Muscle Cells Is the Cell of Origin for Occlusive Pulmonary Vascular Lesions.
作者: Lea C Steffes.;Alexis A Froistad.;Adam Andruska.;Mario Boehm.;Madeleine McGlynn.;Fan Zhang.;Wenming Zhang.;David Hou.;Xuefei Tian.;Lucile Miquerol.;Kari Nadeau.;Ross J Metzger.;Edda Spiekerkoetter.;Maya E Kumar.
来源: Circulation. 2020年142卷16期1545-1561页
Pulmonary arterial hypertension (PAH) is a fatal disease characterized by profound vascular remodeling in which pulmonary arteries narrow because of medial thickening and occlusion by neointimal lesions, resulting in elevated pulmonary vascular resistance and right heart failure. Therapies targeting the neointima would represent a significant advance in PAH treatment; however, our understanding of the cellular events driving neointima formation, and the molecular pathways that control them, remains limited.
7192. Routine Revascularization Versus Initial Medical Therapy for Stable Ischemic Heart Disease: A Systematic Review and Meta-Analysis of Randomized Trials.
作者: Sripal Bangalore.;David J Maron.;Gregg W Stone.;Judith S Hochman.
来源: Circulation. 2020年142卷9期841-857页
Revascularization is often performed in patients with stable ischemic heart disease. However, whether revascularization reduces death and other cardiovascular outcomes is uncertain.
7193. Association of Operator and Hospital Experience With Procedural Success Rates and Outcomes in Patients Undergoing Percutaneous Coronary Interventions for Chronic Total Occlusions: Insights From the Blue Cross Blue Shield of Michigan Cardiovascular Consortium.
作者: Rami Zein.;Milan Seth.;Hussein Othman.;Howard S Rosman.;Thomas Lalonde.;Khaldoon Alaswad.;Daniel Menees.;Edouard Daher.;Rajendra H Mehta.;Hitinder S Gurm.
来源: Circ Cardiovasc Interv. 2020年13卷8期e008863页
An inverse relationship has been described between procedural success and outcomes of all major cardiovascular procedures. However, this relationship has not been studied for percutaneous coronary intervention (PCI) of chronic total occlusion (CTO).
7194. ST-Segment-Elevation Myocardial Infarction During COVID-19 Pandemic: Insights From a Regional Public Service Healthcare Hub.
作者: Mario Gramegna.;Luca Baldetti.;Alessandro Beneduce.;Luigi Pannone.;Giulio Falasconi.;Francesco Calvo.;Vittorio Pazzanese.;Stefania Sacchi.;Matteo Pagnesi.;Francesco Moroni.;Silvia Ajello.;Giulio Melisurgo.;Eustachio Agricola.;Paolo G Camici.;Anna Mara Scandroglio.;Giovanni Landoni.;Fabio Ciceri.;Alberto Zangrillo.;Alberto Maria Cappelletti.
来源: Circ Cardiovasc Interv. 2020年13卷8期e009413页
Coronavirus disease 2019 (COVID-19) pandemic has led to a fast and radical transformation in social, economic, and healthcare networks. COVID-19 outbreak may thus have profound indirect consequences on clinical presentation and management of patients with ST-segment-elevation myocardial infarction (STEMI). Aim of this study was to assess clinical features of patients with STEMI during COVID-19 pandemic.
7197. Plaque Regression and Endothelial Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen (PREMIER).
作者: Subhash Banerjee.;Ping Luo.;Domenic J Reda.;Faisal Latif.;Jeffrey L Hastings.;Ehrin J Armstrong.;Jayant Bagai.;Mazen Abu-Fadel.;Amutharani Baskar.;Preeti Kamath.;Daniel Lippe.;Yongliang Wei.;Alexandra Scrymgeour.;Theresa C Gleason.;Emmanouil S Brilakis.
来源: Circ Cardiovasc Interv. 2020年13卷8期e008933页
Low-density lipoproteins (LDLs) are removed by extracorporeal filtration during LDL apheresis. It is mainly used in familial hyperlipidemia. The PREMIER trial (Plaque Regression and Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen) evaluated LDL apheresis in nonfamilial hyperlipidemia acute coronary syndrome patients treated with percutaneous coronary intervention.
7199. Discharge Prescription Patterns for Antiplatelet Therapy Following Lower Extremity Peripheral Vascular Intervention.
作者: Nikhil Singh.;Li Ding.;Gregory A Magee.;David M Shavelle.;Vikram S Kashyap.;Parveen K Garg.
来源: Circ Cardiovasc Interv. 2020年13卷8期e008791页
Despite current guidelines suggesting a benefit for dual antiplatelet therapy (DAPT) following peripheral vascular intervention (PVI), there are limited data on antiplatelet prescribing patterns post-procedure. We attempted to determine variables associated with DAPT prescription following lower extremity PVI.
7200. Diagnostic Yield of Electroanatomic Voltage Mapping in Guiding Endomyocardial Biopsies.
作者: Michela Casella.;Antonio Dello Russo.;Marco Bergonti.;Valentina Catto.;Edoardo Conte.;Elena Sommariva.;Alessio Gasperetti.;Giulia Vettor.;Fabrizio Tundo.;Rita Sicuso.;Stefania Rizzo.;Saima Mushtaq.;Domenico Della Rocca.;Giulio Pompilio.;Luigi Di Biase.;Daniele Andreini.;Andrea Natale.;Cristina Basso.;Claudio Tondo.
来源: Circulation. 2020年142卷13期1249-1260页
Electroanatomic voltage mapping (EVM) is a promising modality for guiding endomyocardial biopsies (EMBs). However, few data support its feasibility and safety. We now report the largest cohort of patients undergoing EVM-guided EMBs to show its diagnostic yield and to compare it with a cardiac magnetic resonance (CMR)-guided approach.
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