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7171. Prognostic Factors for Advanced Colorectal Neoplasia in Inflammatory Bowel Disease: Systematic Review and Meta-analysis.
作者: Anouk M Wijnands.;Michiel E de Jong.;Maurice W M D Lutgens.;Frank Hoentjen.;Sjoerd G Elias.;Bas Oldenburg.; .
来源: Gastroenterology. 2021年160卷5期1584-1598页
Patients with inflammatory bowel disease (IBD) have an increased risk of colorectal cancer (CRC). We performed a systematic review and meta-analysis to identify all prognostic factors for advanced colorectal neoplasia (aCRN, high-grade dysplasia, or CRC) in patients with IBD.
7174. Common and Rare Variant Prediction and Penetrance of IBD in a Large, Multi-ethnic, Health System-based Biobank Cohort.
作者: Kyle Gettler.;Rachel Levantovsky.;Arden Moscati.;Mamta Giri.;Yiming Wu.;Nai-Yun Hsu.;Ling-Shiang Chuang.;Aleksejs Sazonovs.;Suresh Venkateswaran.;Ujunwa Korie.;Colleen Chasteau.; .;Richard H Duerr.;Mark S Silverberg.;Scott B Snapper.;Mark J Daly.;Dermot P McGovern.;Steven R Brant.;John D Rioux.;Subra Kugathasan.;Carl A Anderson.;Yuval Itan.;Judy H Cho.
来源: Gastroenterology. 2021年160卷5期1546-1557页
Polygenic risk scores (PRS) may soon be used to predict inflammatory bowel disease (IBD) risk in prevention efforts. We leveraged exome-sequence and single nucleotide polymorphism (SNP) array data from 29,358 individuals in the multiethnic, randomly ascertained health system-based BioMe biobank to define effects of common and rare IBD variants on disease prediction and pathophysiology.
7178. STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD.
作者: Dan Turner.;Amanda Ricciuto.;Ayanna Lewis.;Ferdinando D'Amico.;Jasbir Dhaliwal.;Anne M Griffiths.;Dominik Bettenworth.;William J Sandborn.;Bruce E Sands.;Walter Reinisch.;Jürgen Schölmerich.;Willem Bemelman.;Silvio Danese.;Jean Yves Mary.;David Rubin.;Jean-Frederic Colombel.;Laurent Peyrin-Biroulet.;Iris Dotan.;Maria T Abreu.;Axel Dignass.; .
来源: Gastroenterology. 2021年160卷5期1570-1583页
The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) has proposed treatment targets in 2015 for adult patients with inflammatory bowel disease (IBD). We aimed to update the original STRIDE statements for incorporating treatment targets in both adult and pediatric IBD.
7179. Single-Cell Transcriptional Survey of Ileal-Anal Pouch Immune Cells From Ulcerative Colitis Patients.
作者: Joseph C Devlin.;Jordan Axelrad.;Ashley M Hine.;Shannon Chang.;Suparna Sarkar.;Jian-Da Lin.;Kelly V Ruggles.;David Hudesman.;Ken Cadwell.;P'ng Loke.
来源: Gastroenterology. 2021年160卷5期1679-1693页
Restorative proctocolectomy with ileal pouch-anal anastomosis is a surgical procedure in patients with ulcerative colitis refractory to medical therapies. Pouchitis, the most common complication, is inflammation of the pouch of unknown etiology. To define how the intestinal immune system is distinctly organized during pouchitis, we analyzed tissues from patients with and without pouchitis and from patients with ulcerative colitis using single-cell RNA sequencing (scRNA-seq).
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