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6801. Epigenomic Evaluation of Cholangiocyte Transforming Growth Factor-β Signaling Identifies a Selective Role for Histone 3 Lysine 9 Acetylation in Biliary Fibrosis.
作者: Sayed Obaidullah Aseem.;Nidhi Jalan-Sakrikar.;Cheng Chi.;Amaia Navarro-Corcuera.;Thiago M De Assuncao.;Feda H Hamdan.;Shiraj Chowdhury.;Jesus M Banales.;Steven A Johnsen.;Vijay H Shah.;Robert C Huebert.
来源: Gastroenterology. 2021年160卷3期889-905.e10页
Transforming growth factor β (TGFβ) upregulates cholangiocyte-derived signals that activate myofibroblasts and promote fibrosis. Using epigenomic and transcriptomic approaches, we sought to distinguish the epigenetic activation mechanisms downstream of TGFβ that mediate transcription of fibrogenic signals.
6802. Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects.
作者: Xingyi Guo.;Weiqiang Lin.;Wanqing Wen.;Jeroen Huyghe.;Stephanie Bien.;Qiuyin Cai.;Tabitha Harrison.;Zhishan Chen.;Conghui Qu.;Jiandong Bao.;Jirong Long.;Yuan Yuan.;Fangqin Wang.;Mengqiu Bai.;Goncalo R Abecasis.;Demetrius Albanes.;Sonja I Berndt.;Stéphane Bézieau.;D Timothy Bishop.;Hermann Brenner.;Stephan Buch.;Andrea Burnett-Hartman.;Peter T Campbell.;Sergi Castellví-Bel.;Andrew T Chan.;Jenny Chang-Claude.;Stephen J Chanock.;Sang Hee Cho.;David V Conti.;Albert de la Chapelle.;Edith J M Feskens.;Steven J Gallinger.;Graham G Giles.;Phyllis J Goodman.;Andrea Gsur.;Mark Guinter.;Marc J Gunter.;Jochen Hampe.;Heather Hampel.;Richard B Hayes.;Michael Hoffmeister.;Ellen Kampman.;Hyun Min Kang.;Temitope O Keku.;Hyeong Rok Kim.;Loic Le Marchand.;Soo Chin Lee.;Christopher I Li.;Li Li.;Annika Lindblom.;Noralane Lindor.;Roger L Milne.;Victor Moreno.;Neil Murphy.;Polly A Newcomb.;Deborah A Nickerson.;Kenneth Offit.;Rachel Pearlman.;Paul D P Pharoah.;Elizabeth A Platz.;John D Potter.;Gad Rennert.;Lori C Sakoda.;Clemens Schafmayer.;Stephanie L Schmit.;Robert E Schoen.;Fredrick R Schumacher.;Martha L Slattery.;Yu-Ru Su.;Catherine M Tangen.;Cornelia M Ulrich.;Franzel J B van Duijnhoven.;Bethany Van Guelpen.;Kala Visvanathan.;Pavel Vodicka.;Ludmila Vodickova.;Veronika Vymetalkova.;Xiaoliang Wang.;Emily White.;Alicja Wolk.;Michael O Woods.;Graham Casey.;Li Hsu.;Mark A Jenkins.;Stephen B Gruber.;Ulrike Peters.;Wei Zheng.
来源: Gastroenterology. 2021年160卷4期1164-1178.e6页
Susceptibility genes and the underlying mechanisms for the majority of risk loci identified by genome-wide association studies (GWAS) for colorectal cancer (CRC) risk remain largely unknown. We conducted a transcriptome-wide association study (TWAS) to identify putative susceptibility genes.
6803. Famotidine Use Is Not Associated With 30-day Mortality: A Coarsened Exact Match Study in 7158 Hospitalized Patients With Coronavirus Disease 2019 From a Large Healthcare System.
作者: Samrat Yeramaneni.;Pratik Doshi.;Kenneth Sands.;Mandelin Cooper.;Dax Kurbegov.;Gregg Fromell.
来源: Gastroenterology. 2021年160卷3期919-921.e3页 6804. Race, Ethnicity, and Socioeconomic Status Are Associated With Prolonged Time to Treatment After a Diagnosis of Colorectal Cancer: A Large Population-Based Study.
作者: Aileen Bui.;Liu Yang.;Anthony Myint.;Folasade P May.
来源: Gastroenterology. 2021年160卷4期1394-1396.e3页 6817. Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer.
作者: Stephan B Dreyer.;Rosie Upstill-Goddard.;Viola Paulus-Hock.;Clara Paris.;Eirini-Maria Lampraki.;Eloise Dray.;Bryan Serrels.;Giuseppina Caligiuri.;Selma Rebus.;Dennis Plenker.;Zachary Galluzzo.;Holly Brunton.;Richard Cunningham.;Mathias Tesson.;Craig Nourse.;Ulla-Maja Bailey.;Marc Jones.;Kim Moran-Jones.;Derek W Wright.;Fraser Duthie.;Karin Oien.;Lisa Evers.;Colin J McKay.;Grant A McGregor.;Aditi Gulati.;Rachel Brough.;Ilirjana Bajrami.;Stephan Pettitt.;Michele L Dziubinski.;Juliana Candido.;Frances Balkwill.;Simon T Barry.;Robert Grützmann.;Lola Rahib.; .; .;Amber Johns.;Marina Pajic.;Fieke E M Froeling.;Phillip Beer.;Elizabeth A Musgrove.;Gloria M Petersen.;Alan Ashworth.;Margaret C Frame.;Howard C Crawford.;Diane M Simeone.;Chris Lord.;Debabrata Mukhopadhyay.;Christian Pilarsky.;David A Tuveson.;Susanna L Cooke.;Nigel B Jamieson.;Jennifer P Morton.;Owen J Sansom.;Peter J Bailey.;Andrew V Biankin.;David K Chang.
来源: Gastroenterology. 2021年160卷1期362-377.e13页
Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication stress, and novel therapeutic response in PC to develop a biomarker-driven therapeutic strategy targeting DDR and replication stress in PC.
6819. High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell-Derived Organoids.
作者: Tadahiro Shinozawa.;Masaki Kimura.;Yuqi Cai.;Norikazu Saiki.;Yosuke Yoneyama.;Rie Ouchi.;Hiroyuki Koike.;Mari Maezawa.;Ran-Ran Zhang.;Andrew Dunn.;Autumn Ferguson.;Shodai Togo.;Kyle Lewis.;Wendy L Thompson.;Akihiro Asai.;Takanori Takebe.
来源: Gastroenterology. 2021年160卷3期831-846.e10页
Preclinical identification of compounds at risk of causing drug induced liver injury (DILI) remains a significant challenge in drug development, highlighting a need for a predictive human system to study complicated DILI mechanism and susceptibility to individual drug. Here, we established a human liver organoid (HLO)-based screening model for analyzing DILI pathology at organoid resolution.
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