6436. Incidence of Ischemic Stroke in Patients With Asymptomatic Severe Carotid Stenosis Without Surgical Intervention.
作者: Robert W Chang.;Lue-Yen Tucker.;Kara A Rothenberg.;Elizabeth Lancaster.;Rishad M Faruqi.;Hui C Kuang.;Alexander C Flint.;Andrew L Avins.;Mai N Nguyen-Huynh.
来源: JAMA. 2022年327卷20期1974-1982页
Optimal management of patients with asymptomatic severe carotid stenosis is uncertain, due to advances in medical care and a lack of contemporary data comparing medical and surgical treatment.
6437. Effect of Metformin vs Placebo on Invasive Disease-Free Survival in Patients With Breast Cancer: The MA.32 Randomized Clinical Trial.
作者: Pamela J Goodwin.;Bingshu E Chen.;Karen A Gelmon.;Timothy J Whelan.;Marguerite Ennis.;Julie Lemieux.;Jennifer A Ligibel.;Dawn L Hershman.;Ingrid A Mayer.;Timothy J Hobday.;Judith M Bliss.;Priya Rastogi.;Manuela Rabaglio-Poretti.;Som D Mukherjee.;John R Mackey.;Vandana G Abramson.;Conrad Oja.;Robert Wesolowski.;Alastair M Thompson.;Daniel W Rea.;Paul M Stos.;Lois E Shepherd.;Vuk Stambolic.;Wendy R Parulekar.
来源: JAMA. 2022年327卷20期1963-1973页
Metformin, a biguanide commonly used to treat type 2 diabetes, has been associated with potential beneficial effects across breast cancer subtypes in observational and preclinical studies.
6440. Screening for Glaucoma in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
作者: Roger Chou.;Shelley Selph.;Ian Blazina.;Christina Bougatsos.;Rebecca Jungbauer.;Rongwei Fu.;Sara Grusing.;Daniel E Jonas.;Shandiz Tehrani.
来源: JAMA. 2022年327卷20期1998-2012页
Two 2013 systematic reviews to inform the US Preventive Services Task Force (USPSTF) found insufficient evidence to assess benefits and harms of screening for primary open-angle glaucoma (OAG) in adults.
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